Introduction：Basic information about CAS 41708-72-9|Tocainide, including its chemical name, molecular formula, synonyms, physicochemical properties, and safety information, etc.
| Common Name | Tocainide |
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| CAS Number | 41708-72-9 | Molecular Weight | 192.25800 |
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| Density | / | Boiling Point | / |
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| Molecular Formula | C11H16N2O | Melting Point | / |
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| MSDS | / | Flash Point | / |
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Names
| Name | tocainide |
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| Synonym | More Synonyms |
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Tocainide BiologicalActivity
| Description | Tocainide hydrochloride is an orally activesodium channel blocker, it blocks the sodium channels in the pain-producing foci in the nerve membranes. Tocainide hydrochloride is a primary amine analog of lidocaine, can be used for the treatment of tinnitus[1][2]. |
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| Related Catalog | Signaling Pathways >>Membrane Transporter/Ion Channel >>Sodium ChannelResearch Areas >>Cardiovascular Disease |
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| Target | IC50: sodium channel[1] |
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| In Vivo | Tocainide (100 mg/kg) effectively suppresses ventricular ectopic activity in unanesthetized dogs with coronary occlusion. Termination of tocainide infusion in both digitalis toxicity and coronary occlusion models results in prompt return of ventricular ectopic activity[1]. |
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| References | [1]. Alpert JS, et al. Chemistry, pharmacology, antiarrhythmic efficacy and adverse effects of tocainide hydrochloride, an orally active structural analog of lidocaine. Pharmacotherapy. 1983 Nov-Dec;3(6):316-23. [2]. De Luca A,et al.Optimal requirements for high affinity and use-dependent block of skeletal muscle sodium channel by N-benzyl analogs of tocainide-like compounds.Mol Pharmacol. 2003 Oct;64(4):932-45. |
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Chemical & Physical Properties
| Molecular Formula | C11H16N2O |
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| Molecular Weight | 192.25800 |
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| Exact Mass | 192.12600 |
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| PSA | 55.12000 |
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| LogP | 2.36240 |
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| InChIKey | BUJAGSGYPOAWEI-UHFFFAOYSA-N |
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| SMILES | Cc1cccc(C)c1NC(=O)C(C)N |
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| Storage condition | 2-8°C |
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Toxicological Information
CHEMICAL IDENTIFICATION - RTECS NUMBER :
- UG6305000
- CHEMICAL NAME :
- 2',6'-Propionoxylidide, 2-amino-
- CAS REGISTRY NUMBER :
- 41708-72-9
- LAST UPDATED :
- 199707
- DATA ITEMS CITED :
- 4
- MOLECULAR FORMULA :
- C11-H16-N2-O
- MOLECULAR WEIGHT :
- 192.29
- WISWESSER LINE NOTATION :
- ZY1&VMR B1 F1
HEALTH HAZARD DATAACUTE TOXICITY DATA - TYPE OF TEST :
- LDLo - Lowest published lethal dose
- ROUTE OF EXPOSURE :
- Oral
- SPECIES OBSERVED :
- Human - man
- DOSE/DURATION :
- 229 mg/kg
- TOXIC EFFECTS :
- Behavioral - coma Cardiac - cardiomyopathy including infarction
- REFERENCE :
- BMJOAE British Medical Journal. (British Medical Assoc., BMA House, Tavistock Sq., London WC1H 9JR, UK) V.1- 1857- Volume(issue)/page/year: 288,760,1984
- TYPE OF TEST :
- TDLo - Lowest published toxic dose
- ROUTE OF EXPOSURE :
- Oral
- SPECIES OBSERVED :
- Human
- DOSE/DURATION :
- 5714 ug/kg
- TOXIC EFFECTS :
- Behavioral - hallucinations, distorted perceptions Gastrointestinal - nausea or vomiting
- REFERENCE :
- DRFUD4 Drugs of the Future. (J.R. Prous, S.A., Apartado de Correos 540, 08080 Barcelona, Spain) V.1- 1975/76- Volume(issue)/page/year: 2,141,1977
- TYPE OF TEST :
- TDLo - Lowest published toxic dose
- ROUTE OF EXPOSURE :
- Oral
- SPECIES OBSERVED :
- Human - man
- DOSE/DURATION :
- 2606 mg/kg/11W-I
- TOXIC EFFECTS :
- Blood - aplastic anemia
- REFERENCE :
- NEJMAG New England Journal of Medicine. (Massachusetts Medical Soc., 10 Shattuck St., Boston, MA 02115) V.198- 1928- Volume(issue)/page/year: 314,583,1986
- TYPE OF TEST :
- LD50 - Lethal dose, 50 percent kill
- ROUTE OF EXPOSURE :
- Intravenous
- SPECIES OBSERVED :
- Rodent - mouse
- DOSE/DURATION :
- 94 mg/kg
- TOXIC EFFECTS :
- Peripheral Nerve and Sensation - local anesthetic Behavioral - convulsions or effect on seizure threshold Behavioral - ataxia
- REFERENCE :
- JMCMAR Journal of Medicinal Chemistry. (American Chemical Soc., Distribution Office Dept. 223, POB POB 57136, West End Stn., Washington, DC 20037) V.6- 1963- Volume(issue)/page/year: 24,1059,1981
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Safety Information
| Hazard Codes | Xn: Harmful; |
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| Risk Phrases | R22 |
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| HS Code | 2924299090 |
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Customs
| HS Code | 2924299090 |
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| Summary | 2924299090. other cyclic amides (including cyclic carbamates) and their derivatives; salts thereof. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:30.0% |
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Synonyms
| R/S-Tocainide |
| 2-amino-2',6'-propionoxylidide |
| MFCD00072010 |
| EINECS 255-505-0 |
| TOCAINIDE |
| 6'-propionoxylidide,2-amino-2 |
| alanyl-2,6-xylidide |
