CAS 81-64-1|Quinizarin
Introduction：Basic information about CAS 81-64-1|Quinizarin, including its chemical name, molecular formula, synonyms, physicochemical properties, and safety information, etc.
| Common Name | Quinizarin | ||
|---|---|---|---|
| CAS Number | 81-64-1 | Molecular Weight | 240.211 |
| Density | 1.5±0.1 g/cm3 | Boiling Point | 465.3±40.0 °C at 760 mmHg |
| Molecular Formula | C14H8O4 | Melting Point | 198-199 °C(lit.) |
| MSDS | ChineseUSA | Flash Point | 249.3±23.8 °C |
| Symbol | GHS09 | Signal Word | Warning |
Names
| Name | quinizarin |
|---|---|
| Synonym | More Synonyms |
Quinizarin BiologicalActivity
| Description | Quinizarin (1,4-Dihydroxyanthraquinone), a part of the anticancer agents such as Doxorubicin, Daunorubicin, and Adriamycin, interacts with DNA by intercalating mode (Kd=86.1 μM). Quinizarin is used as a fungicide and pesticide chemical and has shown the ability to inhibit tumor cell growth[1][2]. |
|---|---|
| Related Catalog | Research Areas >>CancerResearch Areas >>InfectionSignaling Pathways >>Cell Cycle/DNA Damage >>DNA/RNA SynthesisSignaling Pathways >>Anti-infection >>Fungal |
| In Vitro | 1,4-Dihydroxyanthraquinone (1,4-DHAQ, a fluorophore) doped cellulose (CL) (denoted as 1,4-DHAQ@CL) microporous nanofiber film has been achieved via simple electrospinning and subsequent deacetylating, and used for highly sensitive and selective fluorescence detection of Cu(2+) in aqueous solution[1]. |
| References | [1]. Verebová V, et al. Anthraquinones quinizarin and danthron unwind negatively supercoiled DNA and lengthen linear DNA. Biochem Biophys Res Commun. 2014;444(1):50-55. [2]. Dominic Cheuk, et al. Investigation into solid and solution properties of quinizarin. [3]. Wang M, et al. Electrospun 1,4-DHAQ-doped cellulose nanofiber films for reusable fluorescence detection of trace Cu2+ and further for Cr3+. Environ Sci Technol. 2012;46(1):367-373. |
Chemical & Physical Properties
| Density | 1.5±0.1 g/cm3 |
|---|---|
| Boiling Point | 465.3±40.0 °C at 760 mmHg |
| Melting Point | 198-199 °C(lit.) |
| Molecular Formula | C14H8O4 |
| Molecular Weight | 240.211 |
| Flash Point | 249.3±23.8 °C |
| Exact Mass | 240.042252 |
| PSA | 74.60000 |
| LogP | 4.47 |
| Vapour density | 8.3 (vs air) |
| Vapour Pressure | 0.0±1.2 mmHg at 25°C |
| Index of Refraction | 1.733 |
| InChIKey | GUEIZVNYDFNHJU-UHFFFAOYSA-N |
| SMILES | O=C1c2ccccc2C(=O)c2c(O)ccc(O)c21 |
| Water Solubility | <1 g/L (20 ºC) |
Toxicological Information
CHEMICAL IDENTIFICATION |
ACUTE TOXICITY DATA - TYPE OF TEST :
- Standard Draize test
- ROUTE OF EXPOSURE :
- Administration into the eye
- SPECIES OBSERVED :
- Rodent - rabbit
- TYPE OF TEST :
- LD50 - Lethal dose, 50 percent kill
- ROUTE OF EXPOSURE :
- Oral
- SPECIES OBSERVED :
- Rodent - rat
- DOSE/DURATION :
- >5 gm/kg
- TOXIC EFFECTS :
- Details of toxic effects not reported other than lethal dose value
- TYPE OF TEST :
- LD50 - Lethal dose, 50 percent kill
- ROUTE OF EXPOSURE :
- Intraperitoneal
- SPECIES OBSERVED :
- Rodent - rat
- DOSE/DURATION :
- 2100 mg/kg
- TOXIC EFFECTS :
- Details of toxic effects not reported other than lethal dose value
- TYPE OF TEST :
- LD - Lethal dose
- ROUTE OF EXPOSURE :
- Oral
- SPECIES OBSERVED :
- Rodent - mouse
- DOSE/DURATION :
- >10 gm/kg
- TOXIC EFFECTS :
- Details of toxic effects not reported other than lethal dose value
- TYPE OF TEST :
- LD50 - Lethal dose, 50 percent kill
- ROUTE OF EXPOSURE :
- Intravenous
- SPECIES OBSERVED :
- Rodent - mouse
- DOSE/DURATION :
- 320 mg/kg
- TOXIC EFFECTS :
- Details of toxic effects not reported other than lethal dose value
MUTATION DATA - TYPE OF TEST :
- Mutation in microorganisms
- TEST SYSTEM :
- Bacteria - Salmonella typhimurium
- DOSE/DURATION :
- 100 ug/plate
- REFERENCE :
- MUREAV Mutation Research. (Elsevier Science Pub. B.V., POB 211, 1000 AE Amsterdam, Netherlands) V.1- 1964- Volume(issue)/page/year: 40,203,1976 *** NIOSH STANDARDS DEVELOPMENT AND SURVEILLANCE DATA *** NIOSH OCCUPATIONAL EXPOSURE SURVEY DATA : NOHS - National Occupational Hazard Survey (1974) NOHS Hazard Code - 82067 No. of Facilities: 563 (estimated) No. of Industries: 10 No. of Occupations: 9 No. of Employees: 6634 (estimated)
- TYPE OF TEST :
- Mutation in microorganisms
- TEST SYSTEM :
- Bacteria - Salmonella typhimurium
- DOSE/DURATION :
- 100 ug/plate
- REFERENCE :
- MUREAV Mutation Research. (Elsevier Science Pub. B.V., POB 211, 1000 AE Amsterdam, Netherlands) V.1- 1964- Volume(issue)/page/year: 40,203,1976 *** NIOSH STANDARDS DEVELOPMENT AND SURVEILLANCE DATA *** NIOSH OCCUPATIONAL EXPOSURE SURVEY DATA : NOHS - National Occupational Hazard Survey (1974) NOHS Hazard Code - 82067 No. of Facilities: 563 (estimated) No. of Industries: 10 No. of Occupations: 9 No. of Employees: 6634 (estimated)
Safety Information
| Symbol | GHS09 |
|---|---|
| Signal Word | Warning |
| Hazard Statements | H410 |
| Precautionary Statements | P273-P501 |
| Personal Protective Equipment | Eyeshields;Faceshields;Gloves;type N95 (US);type P1 (EN143) respirator filter |
| Hazard Codes | Xi |
| Risk Phrases | R36/37/38 |
| Safety Phrases | S22-S24/25 |
| RIDADR | UN 3077 9 / PGIII |
| WGK Germany | 2 |
| RTECS | CB6600000 |
| Packaging Group | II; III |
| Hazard Class | 4.1 |
| HS Code | 2914610000 |
Customs
| HS Code | 2914610000 |
|---|---|
| Summary | 2914610000 anthracene-9,10-dione。Supervision conditions:None。VAT:17.0%。Tax rebate rate:9.0%。Lowest tariff:5.5%。General tariff:30.0% |
Articles35
More Articles| In vitro inhibition of Streptococcus mutans biofilm formation on hydroxyapatite by subinhibitory concentrations of anthraquinones. Antimicrob. Agents Chemother. 51 , 1541-4, (2007) We report that certain anthraquinones (AQs) reduce Streptococcus mutans biofilm formation on hydroxyapatite at concentrations below the MIC. Although AQs are known to generate reactive oxygen species,... | |
| Synthesis and activity of substituted anthraquinones against a human filarial parasite, Brugia malayi. J. Med. Chem. 48 , 2822-30, (2005) Lymphatic filariasis (elephantiasis) is a global public health problem caused by the parasitic nematodes Wuchereria bancrofti and Brugia malayi. We have previously reported anthraquinones from daylily... | |
| Synthesis of glycoside derivatives of hydroxyanthraquinone with ability to dissolve and inhibit formation of crystals of calcium oxalate. Potential compounds in kidney stone therapy. Eur. J. Med. Chem. 45 , 1001-7, (2010) Synthesis of glycosyl derivatives of hydroxyanthraquinones (6-10) potentially useful for kidney stone therapy is presented. These compounds were analyzed as inhibitors of calcium oxalate crystals form... |
Synonyms
| MFCD00001209 |
| EINECS 201-368-7 |
| 1,4-hydroxyanthraquinone |
| QUINIZARINE |
| DSD ACID |
| smokeoranger |
| 1,4-Dihydroxy-9,10-anthraquinone |
| Quinizarin |
| Chinizarin |
| 1,4-Dihydroxy-9,10-anthracene-dione |
| 1,4-Dihydroxyanthraquinone |
| 9,10-Anthracenedione, 1,4-dihydroxy- |
| Quinizalin |
| QUINAZARIN |
| 1,4-Doa |
| 1,4-dihydroxyanthracene-9,10-dione |
| quiniazarine |
