CAS 321-38-0|1-Fluoronaphthalene
Introduction：Basic information about CAS 321-38-0|1-Fluoronaphthalene, including its chemical name, molecular formula, synonyms, physicochemical properties, and safety information, etc.
| Common Name | 1-Fluoronaphthalene | ||
|---|---|---|---|
| CAS Number | 321-38-0 | Molecular Weight | 146.161 |
| Density | 1.1±0.1 g/cm3 | Boiling Point | 215.0±0.0 °C at 760 mmHg |
| Molecular Formula | C10H7F | Melting Point | −13 °C(lit.) |
| MSDS | ChineseUSA | Flash Point | 65.6±0.0 °C |
| Symbol | GHS08 | Signal Word | Warning |
Names
| Name | Fluoronaphthalene |
|---|---|
| Synonym | More Synonyms |
1-Fluoronaphthalene BiologicalActivity
| Description | 1-Fluoronaphthalene is an organofluorine compound derived from naphthalene derivatives and fluorinated aromatics. 1-Fluoronaphthalene can be used to synthesize LY248686, a potent inhibitor of serotonin and noradrenaline uptake[1]. |
|---|---|
| Related Catalog | Research Areas >>OthersSignaling Pathways >>Others >>Others |
| In Vitro | 1-Fluoronaphthalene (3 mg, 24 h) can be oxidized by C.elegans ATCC 36112 to form trans-3,4-dihydroxy-3,4-dihydro-1-fluoronaphthalene and trans-5,6-dihydroxy-5,6-dihydro-1-fluoronaphthalene and to form 1-fluoro-8-hydroxy-5-tetralone, 5-hydroxy-1-fluoronaphthalene and 4-hydroxy-1-fluoronaphthalene as well as glucosides, sulfates and glucuronide conjugates of these phenols[1]. |
| References | [1]. C E Cerniglia, et al. Effects of a fluoro substituent on the fungal metabolism of 1-fluoronaphthalene. Appl Environ Microbiol. 1984 Aug;48(2):294-300. |
Chemical & Physical Properties
| Density | 1.1±0.1 g/cm3 |
|---|---|
| Boiling Point | 215.0±0.0 °C at 760 mmHg |
| Melting Point | −13 °C(lit.) |
| Molecular Formula | C10H7F |
| Molecular Weight | 146.161 |
| Flash Point | 65.6±0.0 °C |
| Exact Mass | 146.053177 |
| LogP | 3.50 |
| Vapour Pressure | 0.2±0.4 mmHg at 25°C |
| Index of Refraction | 1.606 |
| InChIKey | CWLKTJOTWITYSI-UHFFFAOYSA-N |
| SMILES | Fc1cccc2ccccc12 |
| Stability | Stable. Incompatible with strong oxidizing agents. |
Toxicological Information
CHEMICAL IDENTIFICATION |
ACUTE TOXICITY DATA - TYPE OF TEST :
- LDLo - Lowest published lethal dose
- ROUTE OF EXPOSURE :
- Oral
- SPECIES OBSERVED :
- Rodent - rat
- DOSE/DURATION :
- 380 mg/kg
- TOXIC EFFECTS :
- Details of toxic effects not reported other than lethal dose value
- REFERENCE :
- JLCMAK Journal of Laboratory and Clinical Medicine. (C.V. Mosby Co., 11830 Westline Industrial Dr., St. Louis, MO 63141) V.1- 1915- Volume(issue)/page/year: 22,1133,1937 *** NIOSH STANDARDS DEVELOPMENT AND SURVEILLANCE DATA *** NIOSH OCCUPATIONAL EXPOSURE SURVEY DATA : NOES - National Occupational Exposure Survey (1983) NOES Hazard Code - X4416 No. of Facilities: 7 (estimated) No. of Industries: 1 No. of Occupations: 1 No. of Employees: 28 (estimated)
Safety Information
| Symbol | GHS08 |
|---|---|
| Signal Word | Warning |
| Hazard Statements | H351 |
| Precautionary Statements | P281 |
| Personal Protective Equipment | Eyeshields;Faceshields;full-face respirator (US);Gloves;multi-purpose combination respirator cartridge (US);type ABEK (EN14387) respirator filter |
| Hazard Codes | Xi:Irritant |
| Risk Phrases | R36/37/38 |
| Safety Phrases | S26-S36-S36/37-S24/25-S23-S53 |
| RIDADR | UN 2810 |
| WGK Germany | 3 |
| RTECS | QJ7100000 |
| HS Code | 2903999090 |
Customs
| HS Code | 2903999090 |
|---|---|
| Summary | 2903999090 halogenated derivatives of aromatic hydrocarbons VAT:17.0% Tax rebate rate:9.0% Supervision conditions:none MFN tariff:5.5% General tariff:30.0% |
Articles5
More Articles| Synthesis of highly oxygenated dinaphthyl ethers via SNAr reactions promoted by Barton's base. Org. Lett. 5(7) , 1155-8, (2003) [reaction: see text] Electron-rich dinaphthyl ethers were synthesized by S(N)Ar reactions between naphthols and activated fluoronaphthalenes. 2-tert-Butyl-1,1,3,3-tetramethylguanidine (Barton's base) ... | |
| Effects of a fluoro substituent on the fungal metabolism of 1-fluoronaphthalene. Appl. Environ. Microbiol. 48(2) , 294-300, (1984) The metabolism of 1-fluoronaphthalene by Cunninghamella elegans ATCC 36112 was studied. The metabolites were isolated by reverse-phase high-pressure liquid chromatography and characterized by the appl... | |
| A one-pot access to 6-substituted phenanthridines from fluoroarenes and nitriles via 1,2-arynes. Org. Lett. 4(16) , 2687-90, (2002) [reaction: see text] A one-pot, t-BuLi-induced synthesis of 6-substituted phenanthridines from fluoroarenes and nitriles via 1,2-arynes is reported. Aryl- and hetaryl nitriles, cyanamides, and trimeth... |
Synonyms
| 1-FLUORONAPTHALENE |
| α-Fluoronaphthalene |
| 1-fluoromaphthalene |
| 1-fluoro-naphthalen |
| Naphthalene, 1-fluoro- |
| EINECS 206-287-0 |
| 1-Fluornaphthalen |
| 4-fluoro-l-naphthalene |
| I-Fluoronaphthalene |
| 1-Flouronaphthalene |
| I-Fluornaphthalin |
| L66J BF |
| MFCD00003873 |
| 1-Fluoronaphthalene |
| 1-Fluornaftalen |
| 1-FLUORO NAPHTHALENE |
