CAS 94-26-8|Butyl 4-Hydroxybenzoate

Introduction：Basic information about CAS 94-26-8|Butyl 4-Hydroxybenzoate, including its chemical name, molecular formula, synonyms, physicochemical properties, and safety information, etc.

Table of Contents

1. Names
2. Butyl 4-Hydroxybenzoate BiologicalActivity
3. Chemical & Physical Properties
4. Toxicological Information
CHEMICAL IDENTIFICATION
HEALTH HAZARD DATA
ACUTE TOXICITY DATA
5. Safety Information
6. Customs
7. Articles82
8. Synonyms

Common Name	Butyl 4-Hydroxybenzoate
CAS Number	94-26-8	Molecular Weight	194.227
Density	1.1±0.1 g/cm3	Boiling Point	309.2±15.0 °C at 760 mmHg
Molecular Formula	C₁₁H₁₄O₃	Melting Point	67-70 °C(lit.)
MSDS	ChineseUSA	Flash Point	129.2±13.2 °C

Names

Name	Butylparaben
Synonym	More Synonyms

Butyl 4-Hydroxybenzoate BiologicalActivity

Description	Butylparaben is an organic compound, has proven to be a highly successful antimicrobial preservative in cosmetics, also used in medication suspensions, and as a flavoring additive in food.
Related Catalog	Signaling Pathways >>Anti-infection >>BacterialResearch Areas >>Infection

Chemical & Physical Properties

Density	1.1±0.1 g/cm3
Boiling Point	309.2±15.0 °C at 760 mmHg
Melting Point	67-70 °C(lit.)
Molecular Formula	C₁₁H₁₄O₃
Molecular Weight	194.227
Flash Point	129.2±13.2 °C
Exact Mass	194.094299
PSA	46.53000
LogP	3.46
Vapour Pressure	0.0±0.7 mmHg at 25°C
Index of Refraction	1.526
InChIKey	QFOHBWFCKVYLES-UHFFFAOYSA-N
SMILES	CCCCOC(=O)c1ccc(O)cc1
Stability	Stable. Combustible. Incompatible with strong oxidizing agents, strong alkalies.
Water Solubility	<0.1 g/100 mL at 17 ºC

Toxicological Information

CHEMICAL IDENTIFICATION

RTECS NUMBER :: DH1980000

CHEMICAL NAME :: Benzoic acid, p-hydroxy-, butyl ester

CAS REGISTRY NUMBER :: 94-26-8

BEILSTEIN REFERENCE NO. :: 1103741

LAST UPDATED :: 199701

DATA ITEMS CITED :: 8

MOLECULAR FORMULA :: C11-H14-O3

MOLECULAR WEIGHT :: 194.25

WISWESSER LINE NOTATION :: QR DVO4

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :: Standard Draize test

ROUTE OF EXPOSURE :: Administration onto the skin

SPECIES OBSERVED :: Rodent - guinea pig

REFERENCE :: JSCCA5 Journal of the Society of Cosmetic Chemists. (Soc. of Cosmetic Chemists, 1995 Broadway, Suite 1701, New York, NY 10023) V.1- 1947- Volume(issue)/page/year: 28,357,1977 ** ACUTE TOXICITY DATA **

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 13200 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: NEZAAQ Nippon Eiseigaku Zasshi. Japanese Journal of Hygiene. (Nippon Eisei Gakkai, c/o Kyoto Daigaku Igakubu, Konoe-cho, Yoshida, Sakyo-ku, Kyoto 606, Japan) V.1- 1946- Volume(issue)/page/year: 28,463,1973

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Intraperitoneal

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 230 mg/kg

TOXIC EFFECTS :: Sense Organs and Special Senses (Eye) - lacrimation

REFERENCE :: JSCCA5 Journal of the Society of Cosmetic Chemists. (Soc. of Cosmetic Chemists, 1995 Broadway, Suite 1701, New York, NY 10023) V.1- 1947- Volume(issue)/page/year: 28,357,1977 ** OTHER MULTIPLE DOSE TOXICITY DATA **

TYPE OF TEST :: TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: 504 gm/kg/12W-C

TOXIC EFFECTS :: Nutritional and Gross Metabolic - weight loss or decreased weight gain Related to Chronic Data - death

REFERENCE :: JAPMA8 Journal of the American Pharmaceutical Association, Scientific Edition. (Washington, DC) V.29-49, 1940-60. For publisher information, see JPMSAE. Volume(issue)/page/year: 45,260,1956 *** U.S. STANDARDS AND REGULATIONS *** EPA FIFRA 1988 PESTICIDE SUBJECT TO REGISTRATION OR RE-REGISTRATION FEREAC Federal Register. (U.S. Government Printing Office, Supt. of Documents, Washington, DC 20402) V.1- 1936- Volume(issue)/page/year: 54,7740,1989 *** NIOSH STANDARDS DEVELOPMENT AND SURVEILLANCE DATA *** NIOSH OCCUPATIONAL EXPOSURE SURVEY DATA : NOHS - National Occupational Hazard Survey (1974) NOHS Hazard Code - 81355 No. of Facilities: 753 (estimated) No. of Industries: 6 No. of Occupations: 17 No. of Employees: 3511 (estimated) NOES - National Occupational Exposure Survey (1983) NOES Hazard Code - 81355 No. of Facilities: 704 (estimated) No. of Industries: 10 No. of Occupations: 32 No. of Employees: 24427 (estimated) No. of Female Employees: 18593 (estimated)

Safety Information

Personal Protective Equipment	Eyeshields;Gloves;type N95 (US);type P1 (EN143) respirator filter
Hazard Codes	Xi
Risk Phrases	R36/37/38
Safety Phrases	S22-S24/25
RIDADR	NONH for all modes of transport
WGK Germany	2
RTECS	DH1980000
HS Code	2918290000

Customs

HS Code	2918290000
Summary	HS: 2918290000 other carboxylic acids with phenol function but without other oxygen function, their anhydrides, halides, peroxides, peroxyacids and their derivatives Tax rebate rate:9.0% Supervision conditions:AB(certificate of inspection for goods inward,certificate of inspection for goods outward) VAT:17.0% MFN tariff:6.5% General tariff:30.0%

Articles82

Parabens determination in cosmetic and personal care products exploiting a multi-syringe chromatographic (MSC) system and chemiluminescent detection.

Talanta 143 , 254-62, (2015)

Parabens are widely used in dairy products, such as in cosmetics and personal care products. Thus, in this work a multi-syringe chromatographic (MSC) system is proposed for the first time for the dete...

Development of eczema vaccinatum in atopic mouse models and efficacy of MVA vaccination against lethal poxviral infection.

PLoS ONE 9(12) , e114374, (2014)

Smallpox vaccine based on live, replicating vaccinia virus (VACV) is associated with several potentially serious and deadly complications. Consequently, a new generation of vaccine based on non-replic...

Characterization of in vitro antifungal activities of small and American cranberry (Vaccinium oxycoccos L. and V. macrocarpon Aiton) and lingonberry (Vaccinium vitis-idaea L.) concentrates in sugar reduced fruit spreads.

Int. J. Food Microbiol. 204 , 111-7, (2015)

In this study, cranberry and lingonberry concentrates were added to commercial sugar-reduced fruit spreads (raspberry-Aloe vera, strawberry-guava, and strawberry-lime), and tested for their antifungal...

Synonyms

butyl para-hydroxybenzoate

EINECS 202-318-7

butylbutex

n-Butyl-paraben

SPF

n-butyl-p-hydroxybenzoate

4-Hydroxybenzoic acid butyl ester

preservalb

p-Hydroxybenzoic acid, n-butyl ester

Lexgard B

Mekkings B

Butylparaben

n-butyl para-hydroxybenzoate

4-hydroxybenzoic acid-n-butyl ester

Nipabutyl

4-Hydroxybenzoic acid, butyl ester

Butyl p-hydroxybenzoate

FEMA 2203

butoben

Butyl Paraben

Benzoic acid, 4-hydroxy-, butyl ester

Butyl parasept

solbrolb

p-hydroxybenzoic acid n-butyl ester

p-Hydroxybenzoic acid, butyl ester

p-hydroxybenzoic acid butyl ester

Butyl 4-hydroxybenzoate

MFCD00016478

n-Butyl-4-hydroxybenzoate

UNII-3QPI1U3FV8

Butyl Parahydroxybenzoate

n-butyl 4-hydroxybenzoate

p-Hydroxybenzoic butyl ester

4-Hydroxybenzoic acid n-butyl ester

Tegosept B

n-butylparaben

tegoseptb

Recommended......