CAS 29621-88-3|selenocystine
Introduction：Basic information about CAS 29621-88-3|selenocystine, including its chemical name, molecular formula, synonyms, physicochemical properties, and safety information, etc.
| Common Name | selenocystine | ||
|---|---|---|---|
| CAS Number | 29621-88-3 | Molecular Weight | 334.091 |
| Density | / | Boiling Point | 538.3±60.0 °C at 760 mmHg |
| Molecular Formula | C6H12N2O4Se2 | Melting Point | 224.5-229.5ºC(lit.) |
| MSDS | ChineseUSA | Flash Point | 279.3±32.9 °C |
| Symbol | GHS06, GHS08, GHS09 | Signal Word | Danger |
Names
| Name | (2R)-2-amino-3-[[(2R)-2-amino-2-carboxyethyl]diselanyl]propanoic acid |
|---|---|
| Synonym | More Synonyms |
selenocystine BiologicalActivity
| Description | L-Selenocystine is a diselenide-bridged amino acid. L-Selenocystine is a redox-active selenium compound that has both anti- and pro-oxidant actions. L-Selenocystine induces an unfolded protein response, ER stress, and large cytoplasmic vacuolization in HeLa cells and has cytostatic effects in a range of cancer cell types[1]. |
|---|---|
| Related Catalog | Research Areas >>OthersSignaling Pathways >>Others >>Others |
| References | [1]. Michio Iwaoka, et al. Synthesis of selenocysteine and selenomethionine derivatives from sulfur-containing amino acids. Chem Biodivers. 2008 Mar;5(3):359-74.Michio Iwaoka, et al. Synthesis of selenocysteine and selenomethionine derivatives from sulfur-containing amino acids. Chem Biodivers. 2008 Mar;5(3):359-74. |
Chemical & Physical Properties
| Boiling Point | 538.3±60.0 °C at 760 mmHg |
|---|---|
| Melting Point | 224.5-229.5ºC(lit.) |
| Molecular Formula | C6H12N2O4Se2 |
| Molecular Weight | 334.091 |
| Flash Point | 279.3±32.9 °C |
| Exact Mass | 335.912750 |
| PSA | 126.64000 |
| LogP | 1.86 |
| Appearance of Characters | Powder | Yellow |
| Vapour Pressure | 0.0±3.1 mmHg at 25°C |
| InChIKey | JULROCUWKLNBSN-IMJSIDKUSA-N |
| SMILES | NC(C[Se][Se]CC(N)C(=O)O)C(=O)O |
| Storage condition | 2-8°C |
Toxicological Information
CHEMICAL IDENTIFICATION |
ACUTE TOXICITY DATA - TYPE OF TEST :
- LD50 - Lethal dose, 50 percent kill
- ROUTE OF EXPOSURE :
- Intraperitoneal
- SPECIES OBSERVED :
- Rodent - rat
- DOSE/DURATION :
- 8463 ug/kg
- TOXIC EFFECTS :
- Details of toxic effects not reported other than lethal dose value
- REFERENCE :
- JPETAB Journal of Pharmacology and Experimental Therapeutics. (Williams & Wilkins Co., 428 E. Preston St., Baltimore, MD 21202) V.1- 1909/10- Volume(issue)/page/year: 108,437,1953 *** REVIEWS *** ACGIH TLV-TWA 0.2 mg(Se)/m3 DTLVS* The Threshold Limit Values (TLVs) and Biological Exposure Indices (BEIs) booklet issues by American Conference of Governmental Industrial Hygienists (ACGIH), Cincinnati, OH, 1996 Volume(issue)/page/year: TLV/BEI,1997 *** OCCUPATIONAL EXPOSURE LIMITS *** OEL-ARAB Republic of Egypt:TWA 0.2 mg(Se)/m3 JAN 1993 OEL-AUSTRALIA:TWA 0.2 mg(Se)/m3 JAN 1993 OEL-BELGIUM:TWA 0.2 mg(Se)/m3 JAN 1993 OEL-DENMARK:TWA 0.1 mg(Se)/m3 JAN 1993 OEL-FINLAND:TWA 0.1 mg(Se)/m3;STEL 0.3 mg(Se)/m3 JAN 1993 OEL-GERMANY:TWA 0.1 mg(Se)/m3 JAN 1993 OEL-HUNGARY:STEL 0.1 mg(Se)/m3 JAN 1993 OEL-THE NETHERLANDS:TWA 0.2 mg(Se)/m3 JAN 1993 OEL-THE PHILIPPINES:TWA 0.2 mg(Se)/m3 JAN 1993 OEL-POLAND:TWA 0.1 mg(Se)/m3 JAN 1993 OEL-SWEDEN:TWA 0.1 mg(Se)/m3 JAN 1993 OEL-SWITZERLAND:TWA 0.1 mg(Se)/m3 JAN 1993 OEL-TURKEY:TWA 0.2 mg(Se)/m3 JAN 1993 OEL-UNITED KINGDOM:TWA 0.1 mg(Se)/m3 JAN 1993 OEL IN BULGARIA, COLOMBIA, JORDAN, KOREA check ACGIH TLV OEL IN NEW ZEALAND, SINGAPORE, VIETNAM check ACGIH TLV
Safety Information
| Symbol | GHS06, GHS08, GHS09 |
|---|---|
| Signal Word | Danger |
| Hazard Statements | H301 + H331-H373-H410 |
| Precautionary Statements | P261-P273-P301 + P310-P311-P501 |
| Personal Protective Equipment | Eyeshields;Faceshields;Gloves;type P2 (EN 143) respirator cartridges |
| Hazard Codes | T: Toxic;N: Dangerous for the environment; |
| Risk Phrases | R23/25 |
| Safety Phrases | S28;S45;S60;S61 |
| RIDADR | UN 3283 6.1/PG 3 |
| WGK Germany | 3 |
| RTECS | AY6032000 |
| Packaging Group | III |
| HS Code | 2930909090 |
Customs
| HS Code | 2930909090 |
|---|---|
| Summary | 2930909090. other organo-sulphur compounds. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:30.0% |
Articles30
More Articles| Determination of selenium and its compounds in marine organisms. J. Trace Elem. Med. Biol. 29 , 91-8, (2015) In this study, we investigate the type and quantity of selenium compounds in fish and marine organisms, using ion-pair reversed phase LC–ICP-MS, developed and applied for the analysis of Atlantic cod,... | |
| Effects of selenium on development, survival, and accumulation in the honeybee (Apis mellifera L.). Environ. Toxicol. Chem. 32(11) , 2584-92, (2013) Apis mellifera L. (Hymenoptera: Apidae) is an important agricultural pollinator in the United States and throughout the world. In areas of selenium (Se) contamination, honeybees may be at risk because... | |
| Selenocystine induces reactive oxygen species–mediated apoptosis in human cancer cells Biomed. Pharmacother. 63(2) , 105-13, (2009) Epidemiological and clinical studies have demonstrated that dietary supplementation of selenium (Se) could reduce the incidence of human cancers. In this study, selenocystine, a nutritionally availabl... |
Synonyms
| selenocystine,(L)-isomer |
| selenocystine |
| L-Selenocystine |
| C6H12N2O4Se2 |
| L-3,3'-Diselenodialanine |
| Seleno-L-cystine Monohydrate |
| seleno-DL-cystine |
| UNII:493154PTZ7 |
| (l,l)-selenocystine |
| (2R,2'R)-3,3'-Diselane-1,2-diylbis(2-aminopropanoic acid) (non-preferred name) |
| (R,R)-3,3'-Diselenobis(2-aminopropionic Acid) Monohydrate |
| L-Alanine,3,3'-diselenobis |
| (2R,2'R)-3,3'-(1,2-Diselanediyl)bis(2-aminopropanoic acid) |
| Seleno-L-cystine |
| Alanine,3,3'-diselenodi-,L |
| MFCD00800971 |
