Introduction：Basic information about CAS 50773-41-6|Polyphyllin D, including its chemical name, molecular formula, synonyms, physicochemical properties, and safety information, etc.
| Common Name | Polyphyllin D |
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| CAS Number | 50773-41-6 | Molecular Weight | 855.017 |
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| Density | 1.4±0.1 g/cm3 | Boiling Point | / |
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| Molecular Formula | C44H70O16 | Melting Point | / |
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| MSDS | / | Flash Point | / |
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Names
| Name | Polyphyllin I |
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| Synonym | More Synonyms |
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Polyphyllin D BiologicalActivity
| Description | Polyphyllin I is a bioactive constituent extracted from Paris polyphylla, has strong anti-tumor activity. Polyphyllin I is an activator of the JNK signaling pathway and is an inhibitor of PDK1/Akt/mTOR signaling. Polyphyllin I induces autophagy, G2/M phase arrest and apoptosis[1][2][3]. |
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| Related Catalog | Signaling Pathways >>PI3K/Akt/mTOR >>mTORSignaling Pathways >>PI3K/Akt/mTOR >>PDK-1Signaling Pathways >>Apoptosis >>ApoptosisResearch Areas >>CancerSignaling Pathways >>Autophagy >>AutophagySignaling Pathways >>PI3K/Akt/mTOR >>AktSignaling Pathways >>MAPK/ERK Pathway >>JNK |
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| Target | JNK signaling[2] PDK1/Akt/mTOR signaling[3] |
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| References | [1]. Kong M, et al. Effects of polyphyllin I on growth inhibition of human non-small lung cancer cells and in xenograft. Acta Biochim Biophys Sin (Shanghai). 2010 Nov;42(11):827-33. [2]. Liu J, et al. Polyphyllin I induces G2/M phase arrest and apoptosis in U251 human glioma cells via mitochondrial dysfunction and the JNK signaling pathway. Acta Biochim Biophys Sin (Shanghai). 2017 Jun 1;49(6):479-486. [3]. He J, et al. Polyphyllin I induces autophagy and cell cycle arrest via inhibiting PDK1/Akt/mTOR signal and downregulating cyclin B1 in human gastric carcinoma HGC-27 cells. Biomed Pharmacother. 2019 Sep;117:109189. |
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Chemical & Physical Properties
| Density | 1.4±0.1 g/cm3 |
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| Molecular Formula | C44H70O16 |
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| Molecular Weight | 855.017 |
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| Exact Mass | 854.466370 |
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| PSA | 235.68000 |
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| LogP | 7.12 |
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| Index of Refraction | 1.618 |
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| InChIKey | LRRDDWMXYOSKIC-GJAFGZJPSA-N |
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| SMILES | CC1CCC2(OC1)OC1CC3C4CC=C5CC(OC6OC(CO)C(OC7OC(CO)C(O)C7O)C(O)C6OC6OC(C)C(O)C(O)C6O)CCC5(C)C4CCC3(C)C1C2C |
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Safety Information
Synonyms
| β-D-Glucopyranoside, (3β,25R)-spirost-5-en-3-yl O-α-L-arabinofuranosyl-(1->4)-O-[6-deoxy-α-L-mannopyranosyl-(1->2)]- |
| (3β,25R)-Spirost-5-en-3-yl α-L-arabinofuranosyl-(1->4)-[6-deoxy-α-L-mannopyranosyl-(1->2)]-β-D-glucopyranoside |
| Chonglou saponin I |
| Polyphyllin A |
| Polyphyllin Ⅰ |
