Introduction：Basic information about CAS 103548-82-9|Huperzine B, including its chemical name, molecular formula, synonyms, physicochemical properties, and safety information, etc.
| Common Name | Huperzine B |
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| CAS Number | 103548-82-9 | Molecular Weight | 256.343 |
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| Density | 1.2±0.1 g/cm3 | Boiling Point | 533.5±50.0 °C at 760 mmHg |
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| Molecular Formula | C16H20N2O | Melting Point | / |
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| MSDS | / | Flash Point | 216.4±30.3 °C |
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Names
| Name | Huperzine B |
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| Synonym | More Synonyms |
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Huperzine B BiologicalActivity
| Description | Huperzine B is a Lycopodium alkaloid isolated from Huperzia serrata and a highly selective acetylcholinesterase (AChE) inhibitor. Huperzine B can be uesd to can be used to improve Alzheimer's disease[1][2]. |
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| Related Catalog | Research Areas >>Neurological DiseaseSignaling Pathways >>Neuronal Signaling >>AChE |
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| Target | AChE[1] |
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| References | [1]. Zhang HY, et al. Huperzine B, a novel acetylcholinesterase inhibitor, attenuates hydrogen peroxide induced injury in PC12 cells. Neurosci Lett. 2000 Sep 29;292(1):41-4. [2]. He XC, et al. Study on dual-site inhibitors of acetylcholinesterase: Highly potent derivatives of bis- and bifunctional huperzine B. Bioorg Med Chem. 2007 Feb 1;15(3):1394-408. |
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Chemical & Physical Properties
| Density | 1.2±0.1 g/cm3 |
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| Boiling Point | 533.5±50.0 °C at 760 mmHg |
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| Molecular Formula | C16H20N2O |
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| Molecular Weight | 256.343 |
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| Flash Point | 216.4±30.3 °C |
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| Exact Mass | 256.157562 |
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| PSA | 44.89000 |
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| LogP | 1.98 |
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| Vapour Pressure | 0.0±1.4 mmHg at 25°C |
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| Index of Refraction | 1.624 |
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| InChIKey | YYWGABLTRMRUIT-HWWQOWPSSA-N |
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| SMILES | CC1=CC2Cc3[nH]c(=O)ccc3C3(C1)NCCCC23 |
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Toxicological Information
CHEMICAL IDENTIFICATION - RTECS NUMBER :
- OL2780000
- CHEMICAL NAME :
- Lycodin-1(18H)-one, 8,15-didehydro-
- CAS REGISTRY NUMBER :
- 103548-82-9
- LAST UPDATED :
- 198912
- DATA ITEMS CITED :
- 2
- MOLECULAR FORMULA :
- C16-H20-N2-O
- MOLECULAR WEIGHT :
- 256.38
HEALTH HAZARD DATAACUTE TOXICITY DATA - TYPE OF TEST :
- LD50 - Lethal dose, 50 percent kill
- ROUTE OF EXPOSURE :
- Intraperitoneal
- SPECIES OBSERVED :
- Rodent - rat
- DOSE/DURATION :
- 43841 ug/kg
- TOXIC EFFECTS :
- Sense Organs and Special Senses (Eye) - lacrimation Behavioral - convulsions or effect on seizure threshold Lungs, Thorax, or Respiration - respiratory depression
- REFERENCE :
- CYLPDN Zhongguo Yaoli Xuebao. Acta Pharmacologica Sinica. Chinese Journal of Pharmacology. (China International Book Trading Corp., POB 2820, Beijing, Peop. Rep. China) V.1- 1980- Volume(issue)/page/year: 8,117,1987
- TYPE OF TEST :
- LD50 - Lethal dose, 50 percent kill
- ROUTE OF EXPOSURE :
- Intraperitoneal
- SPECIES OBSERVED :
- Rodent - mouse
- DOSE/DURATION :
- 25125 ug/kg
- TOXIC EFFECTS :
- Sense Organs and Special Senses (Eye) - lacrimation Behavioral - convulsions or effect on seizure threshold Lungs, Thorax, or Respiration - respiratory depression
- REFERENCE :
- CYLPDN Zhongguo Yaoli Xuebao. Acta Pharmacologica Sinica. Chinese Journal of Pharmacology. (China International Book Trading Corp., POB 2820, Beijing, Peop. Rep. China) V.1- 1980- Volume(issue)/page/year: 8,117,1987
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Synonyms
| HuperzineB |
| (1R,9R,10R)-16-Methyl-6,14-diazatetracyclo[7.5.3.0.0]heptadeca-2(7),3,16-trien-5-one |
| 1H-5,10b-[1]Propeno-1,7-phenanthrolin-8(7H)-one, 2,3,4,4a,5,6-hexahydro-12-methyl-, (4aR,5R,10bR)- |
