CAS 74804-12-9|Adenosine 5'-triphosphate magnesium salt
| Common Name | Adenosine 5'-triphosphate magnesium salt | ||
|---|---|---|---|
| CAS Number | 74804-12-9 | Molecular Weight | 529.47000 |
| Density | / | Boiling Point | / |
| Molecular Formula | C10H14MgN5O13P3 | Melting Point | / |
| MSDS | USA | Flash Point | / |
| Symbol | GHS08 | Signal Word | Warning |
Names
| Name | [[5-(6-aminopurin-9-yl)-3,4-dihydroxyoxolan-2-yl]methoxy-hydroxyphosphoryl] phosphono hydrogen phosphate,magnesium |
|---|---|
| Synonym | More Synonyms |
Adenosine 5'-triphosphate magnesium salt BiologicalActivity
| Description | ATP (Adenosine 5'-triphosphate) dimagnesium is a central component of energy storage and metabolism in vivo. ATP dimagnesium provides the metabolic energy to drive metabolic pumps and serves as a coenzyme in cells. ATP dimagnesium is an important endogenous signaling molecule in immunity and inflammation[1][2]. |
|---|---|
| Related Catalog | Research Areas >>Inflammation/Immunology |
| Target | Human Endogenous Metabolite |
| In Vitro | ATP (5 mM; 1 hour) co-treatment with LPS (1 μg/mL) has a synergistic effect on the activation of the NLRP3 inflammasome in HGFs[3]. ATP (2 mM; 0.5-24 hours) induces secretion of IL-1β, KC and MIP-2 from BMDMs in a caspase-1 activation-dependent manner[4]. ATP promotes neutrophil chemotaxis in vitro[4]. |
| In Vivo | ATP (50 mg/kg; i.p.) protects mice against bacterial infection in vivo[4]. ATP induces the secretion of IL-1β, KC and MIP-2 and neutrophils recruitment in vivo[4]. Animal Model: Four-week-old Kunming mice (18-22 g)[4] Dosage: 50 mg/kg Administration: Intraperitoneal injection, before bacterial (E. coli) challenge Result: Protected mice from bacterial infection. |
| References | [1]. Swennen EL, et al. Immunoregulatory effects of adenosine 5'-triphosphate on cytokine release from stimulated whole blood. Eur J Immunol. 2005 Mar;35(3):852-8. [2]. M J L Bours, et al. Adenosine 5'-triphosphate and adenosine as endogenous signaling molecules in immunity and inflammation. Pharmacol Ther. 2006 Nov;112(2):358-404. [3]. Shuo Xu, et al. Doxycycline inhibits NAcht Leucine-rich repeat Protein 3 inflammasome activation and interleukin-1β production induced by Porphyromonas gingivalis-lipopolysaccharide and adenosine triphosphate in human gingival fibroblasts. Arch Oral Biol. 2019 Nov;107:104514. [4]. Yang Xiang, et al. Adenosine-5'-Triphosphate (ATP) Protects Mice against Bacterial Infection by Activation of the NLRP3 Inflammasome. PLoS One. 2013; 8(5): e63759. |
Chemical & Physical Properties
| Molecular Formula | C10H14MgN5O13P3 |
|---|---|
| Molecular Weight | 529.47000 |
| Exact Mass | 528.96500 |
| PSA | 314.22000 |
| InChIKey | YGXMYKTZDMYISM-IDIVVRGQSA-J |
| SMILES | Nc1ncnc2c1ncn2C1OC(COP(=O)([O-])OP(=O)([O-])OP(=O)([O-])[O-])C(O)C1O.[Mg+2].[Mg+2] |
| Storage condition | 20°C |
Safety Information
| Symbol | GHS08 |
|---|---|
| Signal Word | Warning |
| Hazard Statements | H371 |
| Precautionary Statements | P260 |
| Hazard Codes | Xn: Harmful; |
| Risk Phrases | 20/21/22-68/20/21/22 |
| Safety Phrases | 36/37 |
| RIDADR | NONH for all modes of transport |
Articles8
More Articles| Environmental enrichment reduces methamphetamine cue-induced reinstatement but does not alter methamphetamine reward or VMAT2 function. Behav. Brain Res. 270 , 151-8, (2014) Environmental factors influence a variety of health-related outcomes. In general, being raised in an environment possessing social, sensory, and motor enrichment reduces the rewarding effects of vario... | |
| Atovaquone and quinine anti-malarials inhibit ATP binding cassette transporter activity. Malaria Journal 13 , 359, (2014) Therapeutic blood plasma concentrations of anti-malarial drugs are essential for successful treatment. Pharmacokinetics of pharmaceutical compounds are dependent of adsorption, distribution, metabolis... | |
| Mitochondrial recoupling: a novel therapeutic strategy for cancer? Br. J. Cancer 105 , 469-474, (2011) Recent findings link metabolic transformation of cancer cells to aberrant functions of mitochondrial uncoupling proteins (UCPs). By inducing proton leak, UCPs interfere with mitochondrial synthesis of... |
Synonyms
| Adenosine 5'-triphosphate magnesium salt |
| ATP magnesium salt |
| Adenosine 5 inverted exclamation marka-triphosphate magnesium salt |
| ATP-MG |
