Introduction：Basic information about CAS 127-06-0|Propan-2-one oxime, including its chemical name, molecular formula, synonyms, physicochemical properties, and safety information, etc.
| Common Name | Propan-2-one oxime |
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| CAS Number | 127-06-0 | Molecular Weight | 73.094 |
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| Density | 0.9±0.1 g/cm3 | Boiling Point | 135.0±0.0 °C at 760 mmHg |
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| Molecular Formula | C3H7NO | Melting Point | 60-63 °C(lit.) |
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| MSDS | ChineseUSA | Flash Point | 45.2±8.0 °C |
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Names
| Name | acetone oxime |
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| Synonym | More Synonyms |
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Chemical & Physical Properties
| Density | 0.9±0.1 g/cm3 |
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| Boiling Point | 135.0±0.0 °C at 760 mmHg |
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| Melting Point | 60-63 °C(lit.) |
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| Molecular Formula | C3H7NO |
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| Molecular Weight | 73.094 |
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| Flash Point | 45.2±8.0 °C |
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| Exact Mass | 73.052765 |
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| PSA | 32.59000 |
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| LogP | 0.12 |
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| Vapour Pressure | 4.7±0.5 mmHg at 25°C |
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| Index of Refraction | 1.410 |
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| InChIKey | PXAJQJMDEXJWFB-UHFFFAOYSA-N |
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| SMILES | CC(C)=NO |
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| Water Solubility | 330 g/L (20 ºC) |
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Toxicological Information
CHEMICAL IDENTIFICATION - RTECS NUMBER :
- AL6825000
- CHEMICAL NAME :
- Acetone, oxime
- CAS REGISTRY NUMBER :
- 127-06-0
- BEILSTEIN REFERENCE NO. :
- 1560146
- LAST UPDATED :
- 199712
- DATA ITEMS CITED :
- 4
- MOLECULAR FORMULA :
- C3-H7-N-O
- MOLECULAR WEIGHT :
- 73.11
- WISWESSER LINE NOTATION :
- QNUY1&1
HEALTH HAZARD DATAACUTE TOXICITY DATA - TYPE OF TEST :
- LD - Lethal dose
- ROUTE OF EXPOSURE :
- Oral
- SPECIES OBSERVED :
- Rodent - rat
- DOSE/DURATION :
- >500 mg/kg
- TOXIC EFFECTS :
- Details of toxic effects not reported other than lethal dose value
- REFERENCE :
- NCNSA6 National Academy of Sciences, National Research Council, Chemical-Biological Coordination Center, Review. (Washington, DC) Volume(issue)/page/year: 5,26,1953
- TYPE OF TEST :
- LD50 - Lethal dose, 50 percent kill
- ROUTE OF EXPOSURE :
- Intraperitoneal
- SPECIES OBSERVED :
- Rodent - mouse
- DOSE/DURATION :
- 4 gm/kg
- TOXIC EFFECTS :
- Behavioral - coma
- REFERENCE :
- JPETAB Journal of Pharmacology and Experimental Therapeutics. (Williams & Wilkins Co., 428 E. Preston St., Baltimore, MD 21202) V.1- 1909/10- Volume(issue)/page/year: 119,522,1957
- TYPE OF TEST :
- LD - Lethal dose
- ROUTE OF EXPOSURE :
- Unreported
- SPECIES OBSERVED :
- Rodent - mouse
- DOSE/DURATION :
- >3 gm/kg
- TOXIC EFFECTS :
- Details of toxic effects not reported other than lethal dose value
- REFERENCE :
- PCJOAU Pharmaceutical Chemistry Journal (English Translation). Translation of KHFZAN. (Plenum Pub. Corp., 233 Spring St., New York, NY 10013) No.1- 1967- Volume(issue)/page/year: 12,227,1978
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Safety Information
| Personal Protective Equipment | Eyeshields;Gloves;type N95 (US);type P1 (EN143) respirator filter |
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| Hazard Codes | Xn:Harmful; |
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| Safety Phrases | S22-S24/25 |
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| RIDADR | UN1325 |
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| WGK Germany | 3 |
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| RTECS | AL6825000 |
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| Packaging Group | III |
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| Hazard Class | 4.1 |
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| HS Code | 2928000090 |
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Customs
| HS Code | 2928000090 |
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| Summary | 2928000090 other organic derivatives of hydrazine or of hydroxylamine VAT:17.0% Tax rebate rate:9.0% Supervision conditions:none MFN tariff:6.5% General tariff:20.0% |
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Articles14
More Articles
| Slow oxidation of acetoxime and methylethyl ketoxime to the corresponding nitronates and hydroxy nitronates by liver microsomes from rats, mice, and humans. Toxicol. Sci. 47(2) , 144-50, (1999) Acetoxime and methylethyl ketoxime (MEKO) are tumorigenic in rodents, inducing liver tumors in male animals. The mechanisms of tumorigenicity for these compounds are not well defined. Oxidation of the... | |
| Synthesis and anticancer evaluation of benzyloxyurea derivatives. Chem. Pharm. Bull. 62(9) , 898-905, (2014) A series of novel benzyloxyurea derivatives was designed, synthesized by substituting different benzyls or phenyls on N,N'-positions of the hydroxyurea (HU). These target compounds were evaluated for ... | |
| Reversion of structure-activity relationships of antitumor platinum complexes by acetoxime but not hydroxylamine ligands. Mol. Pharmacol. 71(1) , 357-65, (2007) The presence of cis-configured exchangeable ligands has long been considered a prerequisite for antitumor activity of platinum complexes, but over the past few years, several examples violating this s... | |
Synonyms
| N-Hydroxypropan-2-imine |
| Acetone, oxime |
| β-Isonitrosopropane |
| MFCD00002118 |
| Acetone oxime |
| 2-Propanone, oxime |
| Acetoxime |
| EINECS 204-820-1 |
| b-Isonitrosopropane |
| N-Hydroxy-2-propanimine |
| N-propan-2-ylidenehydroxylamine |
| propan-2-one oxime |
