CAS 33100-27-5|15-Crown-5

Introduction：Basic information about CAS 33100-27-5|15-Crown-5, including its chemical name, molecular formula, synonyms, physicochemical properties, and safety information, etc.

Table of Contents

1. Names
2. 15-Crown-5 BiologicalActivity
3. Chemical & Physical Properties
4. Toxicological Information
CHEMICAL IDENTIFICATION
HEALTH HAZARD DATA
ACUTE TOXICITY DATA
5. Safety Information
6. Customs
7. Synonyms

Common Name	15-Crown-5
CAS Number	33100-27-5	Molecular Weight	220.26
Density	1.0±0.1 g/cm3	Boiling Point	350.9±0.0 °C at 760 mmHg
Molecular Formula	C₁₀H₂₀O₅	Melting Point	-20ºC
MSDS	/	Flash Point	139.1±25.0 °C

Names

Name	15-crown-5
Synonym	More Synonyms

15-Crown-5 BiologicalActivity

Description	15-Crown-5 is a biochemical reagent that can be used as a biological material or organic compound for life science related research.
Related Catalog	Research Areas >>Others
In Vitro	15-Crown-5 用作高效相转移催化剂和络合剂。它用于分离氧鎓离子 (H7O3)+ 盐，尤其是从四氯金酸溶液中。它催化青霉素和头孢菌素系列中羧酸钠盐的O-烷基化，从而在不使用酸的情况下促进酯化反应。它还用于促进醚与受阻醇和氢化钠的威廉姆森合成。与氢化铝锂一起使用，用于在氢溶剂中进行还原反应。此外，它还参与 Horner-Wadsworth-Emmons 反应以从醛制备茋。

Chemical & Physical Properties

Density	1.0±0.1 g/cm3
Boiling Point	350.9±0.0 °C at 760 mmHg
Melting Point	-20ºC
Molecular Formula	C₁₀H₂₀O₅
Molecular Weight	220.26
Flash Point	139.1±25.0 °C
Exact Mass	220.131073
PSA	46.15000
LogP	-0.68
Vapour Pressure	0.0±0.7 mmHg at 25°C
Index of Refraction	1.404
InChIKey	VFTFKUDGYRBSAL-UHFFFAOYSA-N
SMILES	C1COCCOCCOCCOCCO1
Stability	Stable. Incompatible with oxidizing agents, strong acids. Avoid exposure to water or moist air.
Water Solubility	MISCIBLE

Toxicological Information

CHEMICAL IDENTIFICATION

RTECS NUMBER :: SB0200000

CHEMICAL NAME :: 1,4,7,10,13-Pentaoxacyclopentadecane

CAS REGISTRY NUMBER :: 33100-27-5

BEILSTEIN REFERENCE NO. :: 1618144

LAST UPDATED :: 199710

DATA ITEMS CITED :: 10

MOLECULAR FORMULA :: C10-H20-O5

MOLECULAR WEIGHT :: 220.30

WISWESSER LINE NOTATION :: T-15-O DO GO JO MOTJ

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :: Standard Draize test

ROUTE OF EXPOSURE :: Administration onto the skin

SPECIES OBSERVED :: Rodent - rabbit

REFERENCE :: DCTODJ Drug and Chemical Toxicology. (Marcel Dekker, 270 Madison Ave., New York, NY 10016) V.1- 1977/78- Volume(issue)/page/year: 8,451,1985

TYPE OF TEST :: Standard Draize test

ROUTE OF EXPOSURE :: Administration into the eye

SPECIES OBSERVED :: Rodent - rabbit

REFERENCE :: DCTODJ Drug and Chemical Toxicology. (Marcel Dekker, 270 Madison Ave., New York, NY 10016) V.1- 1977/78- Volume(issue)/page/year: 8,451,1985 ** ACUTE TOXICITY DATA **

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: 1410 mg/kg

TOXIC EFFECTS :: Behavioral - tremor

REFERENCE :: DCTODJ Drug and Chemical Toxicology. (Marcel Dekker, 270 Madison Ave., New York, NY 10016) V.1- 1977/78- Volume(issue)/page/year: 1,339,1978

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Intraperitoneal

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: 530 mg/kg

TOXIC EFFECTS :: Behavioral - tremor Behavioral - convulsions or effect on seizure threshold Nutritional and Gross Metabolic - weight loss or decreased weight gain

REFERENCE :: DCTODJ Drug and Chemical Toxicology. (Marcel Dekker, 270 Madison Ave., New York, NY 10016) V.1- 1977/78- Volume(issue)/page/year: 8,451,1985

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 1020 mg/kg

TOXIC EFFECTS :: Behavioral - tremor

REFERENCE :: TXAPA9 Toxicology and Applied Pharmacology. (Academic Press, Inc., 1 E. First St., Duluth, MN 55802) V.1- 1959- Volume(issue)/page/year: 44,263,1978

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Intraperitoneal

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 514 mg/kg

TOXIC EFFECTS :: Behavioral - tremor Behavioral - convulsions or effect on seizure threshold Nutritional and Gross Metabolic - weight loss or decreased weight gain

REFERENCE :: DCTODJ Drug and Chemical Toxicology. (Marcel Dekker, 270 Madison Ave., New York, NY 10016) V.1- 1977/78- Volume(issue)/page/year: 8,451,1985

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Administration onto the skin

SPECIES OBSERVED :: Rodent - rabbit

DOSE/DURATION :: 2520 mg/kg

TOXIC EFFECTS :: Behavioral - tremor Behavioral - convulsions or effect on seizure threshold Nutritional and Gross Metabolic - weight loss or decreased weight gain

REFERENCE :: DCTODJ Drug and Chemical Toxicology. (Marcel Dekker, 270 Madison Ave., New York, NY 10016) V.1- 1977/78- Volume(issue)/page/year: 8,451,1985

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Intraperitoneal

SPECIES OBSERVED :: Rodent - rabbit

DOSE/DURATION :: 560 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: GTPZAB Gigiena Truda i Professional'nye Zabolevaniya. Labor Hygiene and Occupational Diseases. (V/O Mezhdunarodnaya Kniga, 113095 Moscow, USSR) V.1-36, 1957-1992. For publisher information, see MTPEEI Volume(issue)/page/year: 31(2),48,1987

Safety Information

Hazard Codes	Xn:Harmful
Risk Phrases	R20/22;R36
Safety Phrases	S26-S39
RIDADR	2810
WGK Germany	3
RTECS	SB0200000
Packaging Group	III
Hazard Class	6.1(b)
HS Code	29329995

Customs

HS Code	2932999099
Summary	2932999099. other heterocyclic compounds with oxygen hetero-atom(s) only. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:20.0%

Synonyms

15-Crown 5-Ether

15-Crown-5-ether

EINECS 251-379-6

MFCD00005110

1,4,7,10,13-pentaoxacyclopentadecanato

15-Crown-5 ether

1,4,7,10,13-Pentaoxacyclopentadecane

1,4,7,10,13-pentaoxa-cyclopentadecane

1,4,10,13-Pentaoxacyclopentadecane

15-Crown-5

15-C-5 crown ether

1,4,7,10,13-pentaoxycyclopentadecane

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