CAS 951-78-0|2'-deoxyuridine

Introduction：Basic information about CAS 951-78-0|2'-deoxyuridine, including its chemical name, molecular formula, synonyms, physicochemical properties, and safety information, etc.

Table of Contents

1. Names
2. 2'-deoxyuridine BiologicalActivity
3. Chemical & Physical Properties
4. Toxicological Information
CHEMICAL IDENTIFICATION
HEALTH HAZARD DATA
ACUTE TOXICITY DATA
MUTATION DATA
5. Safety Information
6. Articles46
7. Synonyms

Common Name	2'-deoxyuridine
CAS Number	951-78-0	Molecular Weight	228.202
Density	1.5±0.1 g/cm3	Boiling Point	/
Molecular Formula	C₉H₁₂N₂O₅	Melting Point	167-169 °C(lit.)
MSDS	USA	Flash Point	/

Names

Name	2'-deoxyuridine
Synonym	More Synonyms

2'-deoxyuridine BiologicalActivity

Description	2'-Deoxyuridine could increase chromosome breakage and results in a decreased thymidylate synthetase activity. A known use of 2'-Deoxyuridine is as a precursor in the synthesis of Edoxudine.
Related Catalog	Research Areas >>InfectionNatural Products >>Saccharides and Glycosides
Target	Human Endogenous Metabolite
References	[1]. Reidy JA, et al. Deoxyuridine increases folate-sensitive fragile site expression in human lymphocytes. Am J Med Genet. 1987 Jan;26(1):1-5.

Chemical & Physical Properties

Density	1.5±0.1 g/cm3
Melting Point	167-169 °C(lit.)
Molecular Formula	C₉H₁₂N₂O₅
Molecular Weight	228.202
Exact Mass	228.074615
PSA	104.55000
LogP	-1.70
Index of Refraction	1.603
InChIKey	MXHRCPNRJAMMIM-UHFFFAOYSA-N
SMILES	O=c1ccn(C2CC(O)C(CO)O2)c(=O)[nH]1
Storage condition	0-6°C
Water Solubility	300 g/L (20 ºC)

Toxicological Information

CHEMICAL IDENTIFICATION

RTECS NUMBER :: YU7490000

CHEMICAL NAME :: Uridine, 2'-deoxy-

CAS REGISTRY NUMBER :: 951-78-0

BEILSTEIN REFERENCE NO. :: 0024433

LAST UPDATED :: 199701

DATA ITEMS CITED :: 5

MOLECULAR FORMULA :: C9-H12-N2-O5

MOLECULAR WEIGHT :: 228.23

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

MUTATION DATA

TYPE OF TEST :: Mutation in mammalian somatic cells

TEST SYSTEM :: Rodent - hamster Lung

DOSE/DURATION :: 1 mmol/L

REFERENCE :: BICMBE Biochimie. (SPPIF, B.P.22, F-41353 Vineuil, France) V.53- 1971- Volume(issue)/page/year: 64,809,1982

Safety Information

Personal Protective Equipment	Eyeshields;Gloves;type N95 (US);type P1 (EN143) respirator filter
Hazard Codes	Xn
Risk Phrases	R36/37/38
Safety Phrases	S22-S24/25-S37/39
RIDADR	NONH for all modes of transport
WGK Germany	3
RTECS	YU7490000

Articles46

Simultaneous quantification of purine and pyrimidine bases, nucleosides and their degradation products in bovine blood plasma by high performance liquid chromatography tandem mass spectrometry.

J. Chromatogr. A. 1356 , 197-210, (2014)

Improved nitrogen utilization in cattle is important in order to secure a sustainable cattle production. As purines and pyrimidines (PP) constitute an appreciable part of rumen nitrogen, an improved u...

Phase I study of oral gemcitabine prodrug (LY2334737) in Japanese patients with advanced solid tumors.

Cancer Chemother. Pharmacol. 71(6) , 1645-55, (2013)

LY2334737 is an oral gemcitabine prodrug. This Phase I study assessed the safety and tolerability of LY2334737 in Japanese patients with solid tumors and evaluated pharmacokinetics (PK), pharmacodynam...

Quantitative structure-activity relationship and complex network approach to monoamine oxidase A and B inhibitors.

J. Med. Chem. 51 , 6740-51, (2008)

The work provides a new model for the prediction of the MAO-A and -B inhibitor activity by the use of combined complex networks and QSAR methodologies. On the basis of the obtained model, we prepared ...

Synonyms

Uracildeoxyr

deoxyuridine

1-(2-Deoxy-β-D-erythro-pentofuranosyl)-4-hydroxy-2(1H)-pyrimidinone

T6NVMVJ A- ET5OTJ B1Q CQ &&Ribo-β-D Form

2'-deoxy-uridin

2,4(1H,3H)-Pyrimidinedione, 1-(2-deoxy-β-D-erythro-pentofuranosyl)-

1-(2-Deoxy-b-D-erythro-pentofuranosyl)uracil

[131I]-Deoxyuridine

2'-Deoxyuridine

Desoxyuridine

Uridine, 2'-deoxy-

MFCD00006527

2'-dU

EINECS 213-455-7

1-(2-Deoxy-D-erythro-pentofuranosyl)uracil

Deoxyribose uracil

1-(2-deoxy-β-D-ribofuranosyl)-2,4(1H,3H)-Pyrimidinedione

Deoxy-uridin

2′-Deoxyuridine

2(1H)-Pyrimidinone, 1-(2-deoxy-β-D-erythro-pentofuranosyl)-4-hydroxy-

[3H]-Deoxyuridine

1-(2-deoxy-β-D-erythro-pentofuranosyl)uracil

1-(2-deoxy-β-δ-erythro-pentofuranosyl)-2,4(1H,3H)-Pyrimidinedione

1-((2R,4S,5R)-4-Hydroxy-5-(hydroxymethyl)tetrahydrofuran-2-yl)pyrimidine-2,4(1H,3H)-dione

durd

2,4(1H,3H)-Pyrimidinedione, 1-(2-deoxy-β-D-ribofuranosyl)-

1-[(2R,4S,5R)-4-Hydroxy-5-(hydroxymethyl)tetrahydro-2-furanyl]-2,4(1H,3H)-pyrimidinedione

1-(2-deoxy-β-δ-ribofuranosyl)-2,4(1H,3H)-Pyrimidinedione

DEOXYURIDINE-2'

1-(2-deoxy-β-D-erythro-pentofuranosyl)-2,4(1H,3H)-Pyrimidinedione

1-(2-Deoxy-β-D-erythro-pentofuranosyl)pyrimidin-2,4(1H,3H)-dion

2'-DEOXYTHYMIDINE-5'-DIPHOSPHATE TRISODIUM SALT

1-(2-Deoxy-δ-erythro-pentofuranosyl)uracil

Recommended......