CAS 4105-38-8|uridine triacetate

Introduction：Basic information about CAS 4105-38-8|uridine triacetate, including its chemical name, molecular formula, synonyms, physicochemical properties, and safety information, etc.

Table of Contents

1. Names
2. uridine triacetate BiologicalActivity
3. Chemical & Physical Properties
4. Safety Information
5. Articles1
6. Synonyms

Common Name	uridine triacetate
CAS Number	4105-38-8	Molecular Weight	370.311
Density	1.4±0.1 g/cm3	Boiling Point	/
Molecular Formula	C₁₅H₁₈N₂O₉	Melting Point	124-134ºC
MSDS	ChineseUSA	Flash Point	/

Names

Name	2',3',5'-Tri-O-acetyluridine
Synonym	More Synonyms

uridine triacetate BiologicalActivity

Description	Uridine triacetate (Tri-O-acetyl uridine) is an orally active prodrug of Uridine. Uridine triacetate (Tri-O-acetyl uridine) is lipophilic, is quickly absorbed in the gut, and is rapidly deacetylated in the circulation to yield free uridine. Uridine triacetate (Tri-O-acetyl uridine) is uesd for the prevention and treatment of life-threatening 5-fluorouracil and capecitabine toxicity. Uridine triacetate (Tri-O-acetyl uridine) delivers high concentrations of uridine, which competes with toxic 5-FU metabolites[1][2].
Related Catalog	Signaling Pathways >>Others >>Others
References	[1]. Ma WW, et al. Emergency use of uridine triacetate for the prevention and treatment of life-threatening 5-fluorouracil and capecitabine toxicity. Cancer. 2017 Jan 1;123(2):345-356. [2]. Cada DJ, et al. Uridine Triacetate. Hosp Pharm. 2016 Jun;51(6):484-8.

Description

Uridine triacetate (Tri-O-acetyl uridine) is an orally active prodrug of Uridine. Uridine triacetate (Tri-O-acetyl uridine) is lipophilic, is quickly absorbed in the gut, and is rapidly deacetylated in the circulation to yield free uridine. Uridine triacetate (Tri-O-acetyl uridine) is uesd for the prevention and treatment of life-threatening 5-fluorouracil and capecitabine toxicity. Uridine triacetate (Tri-O-acetyl uridine) delivers high concentrations of uridine, which competes with toxic 5-FU metabolites[1][2].

Related Catalog

Signaling Pathways >>Others >>Others

References

[1]. Ma WW, et al. Emergency use of uridine triacetate for the prevention and treatment of life-threatening 5-fluorouracil and capecitabine toxicity. Cancer. 2017 Jan 1;123(2):345-356.

[2]. Cada DJ, et al. Uridine Triacetate. Hosp Pharm. 2016 Jun;51(6):484-8.

Chemical & Physical Properties

Density	1.4±0.1 g/cm3
Melting Point	124-134ºC
Molecular Formula	C₁₅H₁₈N₂O₉
Molecular Weight	370.311
Exact Mass	370.101227
PSA	142.99000
LogP	-0.11
Index of Refraction	1.552
InChIKey	AUFUWRKPQLGTGF-FMKGYKFTSA-N
SMILES	CC(=O)OCC1OC(n2ccc(=O)[nH]c2=O)C(OC(C)=O)C1OC(C)=O
Storage condition	−20°C

Safety Information

Personal Protective Equipment	Eyeshields;Gloves;type N95 (US);type P1 (EN143) respirator filter
Hazard Codes	Xi
RIDADR	NONH for all modes of transport
WGK Germany	3

Articles1

Evaluation of molecularly imprinted polymers using 2',3',5'-tri-O-acyluridines as templates for pyrimidine nucleoside recognition.

Anal. Bioanal. Chem 406(25) , 6275-84, (2014)

In this paper, we describe the synthesis and evaluation of molecularly imprinted polymers (MIPs), prepared using 2',3',5'-tri-O-acyluridines as 'dummy' templates, for the selective recognition of urid...

Synonyms

2',3',5-TRI-ACETYLURIDINE

EINECS 223-881-5

Vistogard

Uridine 2',3',5'-triacetate

2',3',5'-Tri-O-acetyl-rU

2’,3’,5’-Triacetyluridine

Uridine, 2',3',5'-triacetate

2`,3`,5`-Tracetyluridine

TAU

2',3',5'-Tri-O-acety

Tri-O-acetyl uridine

2',3',5'-Tri0acetyluridine

(2R,3R,4R,5R)-2-(Acetoxymethyl)-5-(2,4-dioxo-3,4-dihydropyrimidin-1(2H)-yl)tetrahydrofuran-3,4-diyl diacetate

2',3',5'-Tri-O-acetyluridine

UNII-2WP61F175M

2',3',5'-Triacetyluridine

O2',O3',O5'-triacetyl-uridine

uridine triacetate

Xuriden

2',3',5'-O-triacetyluridine

2`,3`,5`-Triacetyluridine

2',3',5'-trioacetyluridine

MFCD00023795

Vistonuridine

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