CAS 6645-46-1|L-Carnitine hydrochloride

Introduction：Basic information about CAS 6645-46-1|L-Carnitine hydrochloride, including its chemical name, molecular formula, synonyms, physicochemical properties, and safety information, etc.

Table of Contents

1. Names
2. L-Carnitine hydrochloride BiologicalActivity
3. Chemical & Physical Properties
4. Toxicological Information
CHEMICAL IDENTIFICATION
HEALTH HAZARD DATA
ACUTE TOXICITY DATA
5. Safety Information
6. Customs
7. Articles6
8. Synonyms

Common Name	L-Carnitine hydrochloride
CAS Number	6645-46-1	Molecular Weight	197.660
Density	/	Boiling Point	/
Molecular Formula	C₇H₁₆ClNO₃	Melting Point	142 °C
MSDS	USA	Flash Point	/

Names

Name	L-Carnitine hydrochloride
Synonym	More Synonyms

L-Carnitine hydrochloride BiologicalActivity

Description	L-Carnitine hydrochloride ((R)-Carnitine hydrochloride), a highly polar, small zwitterion, is an essential co-factor for the mitochondrial β-oxidation pathway. L-Carnitine hydrochloride functions to transport long chain fatty acyl-CoAs into the mitochondria for degradation by β-oxidation. L-Carnitine hydrochloride is an antioxidant. L-Carnitine hydrochloride can ameliorate metabolic imbalances in many inborn errors of metabolism[1][2][3].
Related Catalog	Research Areas >>Metabolic Disease
Target	Human Endogenous Metabolite
In Vivo	L-Carnitine hydrochloride ((R)-Carnitine hydrochloride) (125, 250 mg/kg; i.p.) has a more pronounced bronchodilator effect in this chronic murine asthma model, and decreases urinary LTE4 excretion[4]. Animal Model: 8- to 10-weeks-old and weighed 28-30g BALB/c mice[4] Dosage: 125, 250 mg/kg Administration: i.p. Result: SaO2 increased significantly at 250 mg/kg and decreased urinaryLTE4 excretion.
References	[1]. Agarwal A, et al. Role of L-carnitine in female infertility. eprod Biol Endocrinol. 2018 Jan 26;16(1):5. [2]. Ferreira GC, et al. L-Carnitine and Acetyl-L-carnitine Roles and Neuroprotection in Developing Brain. Neurochem Res. 2017 Jun;42(6):1661-1675. [3]. Ferreira GC, et al. L-Carnitine and Acetyl-L-carnitine Roles and Neuroprotection in Developing Brain. Neurochem Res. 2017 Jun;42(6):1661-1675. [4]. Uzuner N, et al. The role of L-carnitine in treatment of a murine model of asthma. Acta Med Okayama. 2002 Dec;56(6):295-301.

Chemical & Physical Properties

Melting Point	142 °C
Molecular Formula	C₇H₁₆ClNO₃
Molecular Weight	197.660
Exact Mass	197.081863
PSA	60.36000
InChIKey	JXXCENBLGFBQJM-FYZOBXCZSA-N
SMILES	C[N+](C)(C)CC(O)CC(=O)O.[Cl-]
Water Solubility	soluble

Toxicological Information

CHEMICAL IDENTIFICATION

RTECS NUMBER :: BP2979100

CHEMICAL NAME :: Ammonium, (3-carboxy-2-hydroxypropyl)trimethyl-, chloride, (-)-

CAS REGISTRY NUMBER :: 6645-46-1

LAST UPDATED :: 199703

DATA ITEMS CITED :: 13

MOLECULAR FORMULA :: C7-H15-N-O3.Cl

MOLECULAR WEIGHT :: 196.68

WISWESSER LINE NOTATION :: QV1YQ1K1&1&1 &G

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: 6890 mg/kg

TOXIC EFFECTS :: Vascular - other changes Gastrointestinal - hypermotility, diarrhea Skin and Appendages - hair

REFERENCE :: IYKEDH Iyakuhin Kenkyu. Study of Medical Supplies. (Nippon Koteisho Kyokai, 12-15, 2-chome, Shibuya, Shibuya-ku, Tokyo 150, Japan) V.1- 1970- Volume(issue)/page/year: 19,191,1988

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Intraperitoneal

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: 1920 mg/kg

TOXIC EFFECTS :: Vascular - other changes Gastrointestinal - hypermotility, diarrhea Skin and Appendages - hair

REFERENCE :: IYKEDH Iyakuhin Kenkyu. Study of Medical Supplies. (Nippon Koteisho Kyokai, 12-15, 2-chome, Shibuya, Shibuya-ku, Tokyo 150, Japan) V.1- 1970- Volume(issue)/page/year: 19,191,1988

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Subcutaneous

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: >5 gm/kg

TOXIC EFFECTS :: Skin and Appendages - dermatitis, other (after systemic exposure) Skin and Appendages - hair

REFERENCE :: IYKEDH Iyakuhin Kenkyu. Study of Medical Supplies. (Nippon Koteisho Kyokai, 12-15, 2-chome, Shibuya, Shibuya-ku, Tokyo 150, Japan) V.1- 1970- Volume(issue)/page/year: 19,191,1988

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Intravenous

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: 1440 mg/kg

TOXIC EFFECTS :: Vascular - other changes Gastrointestinal - hypermotility, diarrhea Skin and Appendages - hair

REFERENCE :: IYKEDH Iyakuhin Kenkyu. Study of Medical Supplies. (Nippon Koteisho Kyokai, 12-15, 2-chome, Shibuya, Shibuya-ku, Tokyo 150, Japan) V.1- 1970- Volume(issue)/page/year: 19,191,1988

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 8 gm/kg

TOXIC EFFECTS :: Behavioral - somnolence (general depressed activity) Behavioral - changes in motor activity (specific assay) Lungs, Thorax, or Respiration - respiratory depression

REFERENCE :: IYKEDH Iyakuhin Kenkyu. Study of Medical Supplies. (Nippon Koteisho Kyokai, 12-15, 2-chome, Shibuya, Shibuya-ku, Tokyo 150, Japan) V.1- 1970- Volume(issue)/page/year: 19,446,1988

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Intraperitoneal

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 1690 mg/kg

TOXIC EFFECTS :: Behavioral - somnolence (general depressed activity) Behavioral - changes in motor activity (specific assay) Lungs, Thorax, or Respiration - respiratory depression

REFERENCE :: IYKEDH Iyakuhin Kenkyu. Study of Medical Supplies. (Nippon Koteisho Kyokai, 12-15, 2-chome, Shibuya, Shibuya-ku, Tokyo 150, Japan) V.1- 1970- Volume(issue)/page/year: 19,446,1988

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Subcutaneous

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 4320 mg/kg

TOXIC EFFECTS :: Behavioral - somnolence (general depressed activity) Behavioral - changes in motor activity (specific assay) Lungs, Thorax, or Respiration - respiratory depression

REFERENCE :: IYKEDH Iyakuhin Kenkyu. Study of Medical Supplies. (Nippon Koteisho Kyokai, 12-15, 2-chome, Shibuya, Shibuya-ku, Tokyo 150, Japan) V.1- 1970- Volume(issue)/page/year: 19,446,1988

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Intravenous

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 3100 mg/kg

TOXIC EFFECTS :: Behavioral - somnolence (general depressed activity) Behavioral - changes in motor activity (specific assay) Lungs, Thorax, or Respiration - respiratory depression

REFERENCE :: IYKEDH Iyakuhin Kenkyu. Study of Medical Supplies. (Nippon Koteisho Kyokai, 12-15, 2-chome, Shibuya, Shibuya-ku, Tokyo 150, Japan) V.1- 1970- Volume(issue)/page/year: 19,446,1988

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Intravenous

SPECIES OBSERVED :: Mammal - dog

DOSE/DURATION :: 2272 mg/kg

TOXIC EFFECTS :: Vascular - other changes Gastrointestinal - hypermotility, diarrhea Skin and Appendages - hair

REFERENCE :: IYKEDH Iyakuhin Kenkyu. Study of Medical Supplies. (Nippon Koteisho Kyokai, 12-15, 2-chome, Shibuya, Shibuya-ku, Tokyo 150, Japan) V.1- 1970- Volume(issue)/page/year: 19,238,1988

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - rabbit

DOSE/DURATION :: 5400 mg/kg

TOXIC EFFECTS :: Behavioral - changes in motor activity (specific assay) Lungs, Thorax, or Respiration - respiratory depression Gastrointestinal - hypermotility, diarrhea

REFERENCE :: IYKEDH Iyakuhin Kenkyu. Study of Medical Supplies. (Nippon Koteisho Kyokai, 12-15, 2-chome, Shibuya, Shibuya-ku, Tokyo 150, Japan) V.1- 1970- Volume(issue)/page/year: 19,446,1988

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Intravenous

SPECIES OBSERVED :: Rodent - rabbit

DOSE/DURATION :: 1200 mg/kg

TOXIC EFFECTS :: Behavioral - somnolence (general depressed activity) Behavioral - changes in motor activity (specific assay) Lungs, Thorax, or Respiration - respiratory depression

REFERENCE :: IYKEDH Iyakuhin Kenkyu. Study of Medical Supplies. (Nippon Koteisho Kyokai, 12-15, 2-chome, Shibuya, Shibuya-ku, Tokyo 150, Japan) V.1- 1970- Volume(issue)/page/year: 19,446,1988 ** OTHER MULTIPLE DOSE TOXICITY DATA **

TYPE OF TEST :: TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: 728 gm/kg/52W-I

TOXIC EFFECTS :: Kidney, Ureter, Bladder - urine volume increased Nutritional and Gross Metabolic - weight loss or decreased weight gain Related to Chronic Data - death

REFERENCE :: IYKEDH Iyakuhin Kenkyu. Study of Medical Supplies. (Nippon Koteisho Kyokai, 12-15, 2-chome, Shibuya, Shibuya-ku, Tokyo 150, Japan) V.1- 1970- Volume(issue)/page/year: 19,221,1988 ** REPRODUCTIVE DATA **

TYPE OF TEST :: TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :: Oral

DOSE :: 33 gm/kg

SEX/DURATION :: female 7-17 day(s) after conception

TOXIC EFFECTS :: Reproductive - Specific Developmental Abnormalities - musculoskeletal system Reproductive - Effects on Newborn - behavioral

REFERENCE :: IYKEDH Iyakuhin Kenkyu. Study of Medical Supplies. (Nippon Koteisho Kyokai, 12-15, 2-chome, Shibuya, Shibuya-ku, Tokyo 150, Japan) V.1- 1970- Volume(issue)/page/year: 19,465,1988

Safety Information

Personal Protective Equipment	dust mask type N95 (US);Eyeshields;Gloves
Hazard Codes	Xi:Irritant
Risk Phrases	R36/37/38
Safety Phrases	S26-S37/39
RIDADR	NONH for all modes of transport
WGK Germany	2
RTECS	BP2979100
HS Code	2923900090

Customs

HS Code	2923900090
Summary	2923900090 other quaternary ammonium salts and hydroxides。Supervision conditions:None。VAT:17.0%。Tax rebate rate:9.0%。MFN tariff:6.5%。General tariff:30.0%

Articles6

Amelioration of palmitate-induced metabolic dysfunction in L6 muscle cells expressing low levels of receptor-interacting protein 140.

Can. J. Physiol. Pharmacol. 93 , 913-22, (2015)

We have shown that reduced expression of receptor-interacting protein 140 (RIP140) alters the regulation of fatty-acid (FA) oxidation in muscle. To determine whether a high level of FA availability al...

To Break or to Brake Neuronal Network Accelerated by Ammonium Ions?

PLoS ONE 10 , e0134145, (2015)

The aim of present study was to investigate the effects of ammonium ions on in vitro neuronal network activity and to search alternative methods of acute ammonia neurotoxicity prevention.Rat hippocamp...

Regulation of cardiac gene expression by KLF15, a repressor of myocardin activity.

J. Biol. Chem. 285 , 27449-27456, (2010)

Pathological forms of left ventricular hypertrophy (LVH) often progress to heart failure. Specific transcription factors have been identified that activate the gene program to induce pathological form...

Synonyms

(−)-β-Hydroxy-γ-(trimethylammonio)butyrate

3-Carboxy-2-hydroxy-N,N,N-trimethyl-1-propanaminium chloride

3-Hydroxy-4-(trimethylammonio)butanoate hydrochloride

Vitamin BT Hydrochloride

Carnitine chloride

L-CARNITINE HYDROCHLORIDE

3-Hydroxy-4-(trimethylammonio)butyrate Hydrochloride

(R)-3-Carboxy-2-hydroxy-N,N,N-trimethyl-1-propanaminium chloride

MFCD00066100

L(-)-Carnitine hydrochloride

[(2R)-3-carboxy-2-hydroxypropyl]-trimethylazanium,chloride

(2R)-3-Carboxy-2-hydroxy-N,N,N-trimethyl-1-propanaminium, inner salt, hydrochloride (1:1)

LEVOCARNITINE HYDROCHLORIDE

(R)-3-Hydroxy-4-(trimethylammonio)butanoate hydrochloride

3-Carboxy-2-hydroxy-N,N,N-trimethyl-1-propanaminium, inner salt, hydrochloride (1:1)

(2R)-3-Carboxy-2-hydroxy-N,N,N-trimethyl-1-propanaminium chloride

QV1YQ1K1&1&1 &&Anhydro HCl

DL-Carnitine Hydrochloride

EINECS 229-663-6

UNII:F64264D63N

(R)-Carnitine hydrochloride

L-(-)-Carnitine hydrochloride

carnitine hydrochloride

QV1YQ1K1&1&1 &&Chloride

(3R)-3-Hydroxy-4-(trimethylammonio)butyrate hydrochloride

(3R)-3-Hydroxy-4-(trimethylammonio)butanoate hydrochloride (1:1)

1-Propanaminium, 3-carboxy-2-hydroxy-N,N,N-trimethyl-, chloride, (2R)- (1:1)

Levocarnitine chloride

VITAMIN BT

(3R)-3-Hydroxy-4-(trimethylammonio)butanoate hydrochloride

L-Carnitine HCl

1-Propanaminium, 3-carboxy-2-hydroxy-N,N,N-trimethyl-, chloride (1:1)

3-Carboxy-2-hydroxy-N,N,N-trimethylpropan-1-aminium chloride

(R)-3-Hydroxy-4-(trimethylammonio)butyrate hydrochloride

1-propanaminium, 3-carboxy-2-hydroxy-N,N,N-trimethyl-, inner salt, (2R)-, hydrochloride (1:1)

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