Introduction：Basic information about CAS 1769-24-0|2-Methylquinazolin-4-ol, including its chemical name, molecular formula, synonyms, physicochemical properties, and safety information, etc.
| Common Name | 2-Methylquinazolin-4-ol |
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| CAS Number | 1769-24-0 | Molecular Weight | 160.17300 |
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| Density | 1.26 g/cm3 | Boiling Point | 305.4ºC at 760 mmHg |
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| Molecular Formula | C9H8N2O | Melting Point | 231-233ºC(lit.) |
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| MSDS | / | Flash Point | 138.5ºC |
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Names
| Name | 2-Methylquinazolin-4-ol |
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| Synonym | More Synonyms |
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2-Methylquinazolin-4-ol BiologicalActivity
| Description | 2-Methylquinazolin-4-ol is a potent competitive poly(ADP-ribose) synthetase inhibitor, with a Ki of 1.1 μM. 2-Methylquinazolin-4-ol mammalian aspartate transcarbamylase (ATCase) inhibitor, with 0.20 mM[1][2]. |
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| Related Catalog | Signaling Pathways >>Epigenetics >>PARPResearch Areas >>OthersSignaling Pathways >>Cell Cycle/DNA Damage >>PARP |
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| In Vitro | 2-Methylquinazolin-4-ol inhibits ATCase in a concentration-dependent manner[1]. |
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| In Vivo | 2-Methylquinazolin-4-ol (0.2-1 mg; i.g.; for two days) inhibits ATCase in a dosedependent manner in vivo[2]. Animal Model: Mice[2] Dosage: 0.2 mg, 0.4 mg, 0.6 mg, 0.8 mg, 1 mg Administration: Oral gavage, for two days Result: Showed an inhibitory effect upon ATCase. |
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| References | [1]. S Yoshida, et al. Production of 2-methyl-4[3H]-quinazolinone, an inhibitor of poly(ADP-ribose) synthetase, by bacterium. J Antibiot (Tokyo). 1991 Jan;44(1):111-2. [2]. Mahmoud Balbaa, et al. Inhibition of mammalian aspartate transcarbamylase by quinazolinone derivatives. J Enzyme Inhib Med Chem. 2008 Aug;23(4):483-92. |
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Chemical & Physical Properties
| Density | 1.26 g/cm3 |
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| Boiling Point | 305.4ºC at 760 mmHg |
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| Melting Point | 231-233ºC(lit.) |
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| Molecular Formula | C9H8N2O |
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| Molecular Weight | 160.17300 |
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| Flash Point | 138.5ºC |
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| Exact Mass | 160.06400 |
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| PSA | 45.75000 |
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| LogP | 1.23150 |
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Toxicological Information
CHEMICAL IDENTIFICATION - RTECS NUMBER :
- VA3677000
- CHEMICAL NAME :
- 4(3H)-Quinazolinone, 2-methyl-
- CAS REGISTRY NUMBER :
- 1769-24-0
- LAST UPDATED :
- 199609
- DATA ITEMS CITED :
- 3
- MOLECULAR FORMULA :
- C9-H8-N2-O
- MOLECULAR WEIGHT :
- 160.19
- WISWESSER LINE NOTATION :
- T66 BVM ENJ D1
HEALTH HAZARD DATAACUTE TOXICITY DATA - TYPE OF TEST :
- LD50 - Lethal dose, 50 percent kill
- ROUTE OF EXPOSURE :
- Oral
- SPECIES OBSERVED :
- Rodent - mouse
- DOSE/DURATION :
- 859 mg/kg
- TOXIC EFFECTS :
- Details of toxic effects not reported other than lethal dose value
- REFERENCE :
- ARZNAD Arzneimittel-Forschung. Drug Research. (Editio Cantor Verlag, Postfach 1255, W-7960 Aulendorf, Fed. Rep. Ger.) V.1- 1951- Volume(issue)/page/year: 12,1204,1962
- TYPE OF TEST :
- LD50 - Lethal dose, 50 percent kill
- ROUTE OF EXPOSURE :
- Intraperitoneal
- SPECIES OBSERVED :
- Rodent - mouse
- DOSE/DURATION :
- 592 mg/kg
- TOXIC EFFECTS :
- Details of toxic effects not reported other than lethal dose value
- REFERENCE :
- ARZNAD Arzneimittel-Forschung. Drug Research. (Editio Cantor Verlag, Postfach 1255, W-7960 Aulendorf, Fed. Rep. Ger.) V.1- 1951- Volume(issue)/page/year: 12,1204,1962
- TYPE OF TEST :
- LD50 - Lethal dose, 50 percent kill
- ROUTE OF EXPOSURE :
- Parenteral
- SPECIES OBSERVED :
- Rodent - mouse
- DOSE/DURATION :
- 500 mg/kg
- TOXIC EFFECTS :
- Autonomic Nervous System - smooth muscle relaxant (mechanism undefined, spasmolytic) Behavioral - tremor Behavioral - muscle weakness
- REFERENCE :
- PCJOAU Pharmaceutical Chemistry Journal (English Translation). Translation of KHFZAN. (Plenum Pub. Corp., 233 Spring St., New York, NY 10013) No.1- 1967- Volume(issue)/page/year: 7,626,1973
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Safety Information
| Hazard Codes | Xi: Irritant; |
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| Risk Phrases | R36/37/38 |
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| Safety Phrases | S26;S37/S39 |
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| WGK Germany | 3 |
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| RTECS | VA3677000 |
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| HS Code | 2933990090 |
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Customs
| HS Code | 2933990090 |
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| Summary | 2933990090. heterocyclic compounds with nitrogen hetero-atom(s) only. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:20.0% |
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Synonyms
| EINECS 217-189-2 |
| MFCD00006887 |
| 2-methyl-4(3h)-quinazolinone |
