CAS 74103-06-3|Ketorolac

Introduction：Basic information about CAS 74103-06-3|Ketorolac, including its chemical name, molecular formula, synonyms, physicochemical properties, and safety information, etc.

Table of Contents

1. Names
2. Ketorolac BiologicalActivity
3. Chemical & Physical Properties
4. Toxicological Information
CHEMICAL IDENTIFICATION
HEALTH HAZARD DATA
ACUTE TOXICITY DATA
5. Safety Information
6. Synonyms

Common Name	Ketorolac
CAS Number	74103-06-3	Molecular Weight	255.269
Density	1.3±0.1 g/cm3	Boiling Point	493.2±40.0 °C at 760 mmHg
Molecular Formula	C₁₅H₁₃NO₃	Melting Point	160-161°C
MSDS	/	Flash Point	252.1±27.3 °C

Names

Name	Ketorolac
Synonym	More Synonyms

Ketorolac BiologicalActivity

Description	Ketorolac is a non-steroidal anti-inflammatory agent, acting as a nonselective COX inhibitor, with IC50s of 20 nM for COX-1 and 120 nM for COX-2.
Related Catalog	Research Areas >>Inflammation/Immunology
Target	COX-1:20 nM (IC50) COX-2:120 nM (IC50)
In Vitro	Ketorolac is a non-steroidal anti-inflammatory agent, acting as a nonselective COX inhibitor, with IC50s of 20 nM for COX-1 and 120 nM for COX-2[1].
In Vivo	Ketorolac tromethamine (0.4%) causes nearly complete inhibition on LPS endotoxin-induced increases in FITC-dextran in the anterior chamber, and increases in aqueous PGE2 concentrations in the aqueous humor in rabbits[1].Ketorolac (30 mg/kg, i.v.) rapidly reverses hyperalgesia in rats. Ketorolac also reduces carrageenan-induced hyperalgesia and paw PG production, and causes reduction in PGE2 levels in rats[1]. Ketorolac (4 mg/kg/day, p.o.) has no detrimental effect in the volume fraction of bone trabeculae formed inside the alveolar socket in rats[2]. Ketorolac (60 μg/10 μL) reduces the histological changes such as ischemic cell death, including cytoplasmic eosinophilia with disintegration of cytoarchitecture and nuclear pyknosis in rats. Ketorolac also effectively reduces neuronal death and improves hindlimb motor function, and the long-term survival is similar to that in the control group[3].
Animal Admin	Rats[2] Treated rats receive oral doses of 1 mL aqueous solution of paracetamol (80 mg/kg/rat/day), Ketorolac (4 mg/kg/day) or etoricoxib (10 mg/kg/day) administered by gavage from the day of surgery until death, 2 weeks later. Control rats receive tap water (1 mL/day by gavage). The animals are housed under climate-controlled environment (12 h light/12 h dark, 20-24ºC) with free access to standard laboratory chow and tap water[2].
References	[1]. Waterbury LD, et al. Comparison of cyclooxygenase inhibitory activity and ocular anti-inflammatory effects of ketorolac tromethamine and bromfenac sodium. Curr Med Res Opin. 2006 Jun;22(6):1133-40. [2]. Fracon RN, et al. Treatment with paracetamol, ketorolac or etoricoxib did not hinder alveolar bone healing: a histometric study in rats. J Appl Oral Sci. 2010 Dec;18(6):630-4. [3]. Hsieh YC, et al. Intrathecal ketorolac pretreatment reduced spinal cord ischemic injury in rats. Anesth Analg. 2005 Apr;100(4):1134-9.

Chemical & Physical Properties

Density	1.3±0.1 g/cm3
Boiling Point	493.2±40.0 °C at 760 mmHg
Melting Point	160-161°C
Molecular Formula	C₁₅H₁₃NO₃
Molecular Weight	255.269
Flash Point	252.1±27.3 °C
Exact Mass	255.089539
PSA	59.30000
LogP	2.08
Vapour Pressure	0.0±1.3 mmHg at 25°C
Index of Refraction	1.659
InChIKey	OZWKMVRBQXNZKK-UHFFFAOYSA-N
SMILES	O=C(c1ccccc1)c1ccc2n1CCC2C(=O)O

Toxicological Information

CHEMICAL IDENTIFICATION

RTECS NUMBER :: UY7759800

CHEMICAL NAME :: 1H-Pyrrolizine-1-carboxylic acid, 2,3-dihydro-5-benzoyl-, (+-)-

CAS REGISTRY NUMBER :: 74103-06-3

LAST UPDATED :: 199703

DATA ITEMS CITED :: 2

MOLECULAR FORMULA :: C15-H13-N-O3

MOLECULAR WEIGHT :: 255.29

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 200 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: AGACBH Agents and Actions, A Swiss Journal of Pharmacology. (Birkhaeuser Verlag, POB 133, CH-4010 Basel, Switzerland) V.1- 1969/70- Volume(issue)/page/year: 12,684,1982

TYPE OF TEST :: LDLo - Lowest published lethal dose

ROUTE OF EXPOSURE :: Intraperitoneal

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 100 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: AGACBH Agents and Actions, A Swiss Journal of Pharmacology. (Birkhaeuser Verlag, POB 133, CH-4010 Basel, Switzerland) V.1- 1969/70- Volume(issue)/page/year: 12,684,1982

Safety Information

Hazard Codes	Xi
RIDADR	3249
Packaging Group	II
Hazard Class	6.1(a)

Synonyms

Lixidol

1H-Pyrrolizine-1-carboxylic acid, 2,3-dihydro-5-(phenyl-d-carbonyl)-

5-[(H)Phenylcarbonyl]-2,3-dihydro-1H-pyrrolizine-1-carboxylic acid

Ketorolac

Tm-asyn

5-Benzoyl-2,3-dihydro-1H-pyrrolizine-1-carboxylic acid

Fluoxetin

MFCD00864281

1H-Pyrrolizine-1-carboxylic acid, 5-benzoyl-2,3-dihydro-

Dolac

Toratex

KETOROLAC-D5

5-(phenylcarbonyl)-2,3-dihydro-1H-pyrrolizine-1-carboxylic acid

Acular

Ketoralac

UNII:YZI5105V0L

Recommended......