CAS 94-44-0|Benzyl nicotinate (JAN)
| Common Name | Benzyl nicotinate (JAN) | ||
|---|---|---|---|
| CAS Number | 94-44-0 | Molecular Weight | 213.232 |
| Density | 1.2±0.1 g/cm3 | Boiling Point | 334.1±17.0 °C at 760 mmHg |
| Molecular Formula | C13H11NO2 | Melting Point | 24 °C(lit.) |
| MSDS | ChineseUSA | Flash Point | 155.8±20.9 °C |
| Symbol | GHS07 | Signal Word | Warning |
Names
| Name | Benzyl nicotinate |
|---|---|
| Synonym | More Synonyms |
Benzyl nicotinate (JAN) BiologicalActivity
| Description | Benzyl nicotinate, a vasodilator, is used as an active ingredient that causes hyperemia[1][2]. |
|---|---|
| Related Catalog | Research Areas >>Cardiovascular DiseaseSignaling Pathways >>Others >>Others |
| References | [1]. Erjavec V, et al. In vivo study of liposomes as drug carriers to oral mucosa using EPR oximetry. Int J Pharm. 2006;307(1):1-8. [2]. Petelin M, et al. In vivo study of different ointments for drug delivery into oral mucosa by EPR oximetry. Int J Pharm. 2004;270(1-2):83-91. |
Chemical & Physical Properties
| Density | 1.2±0.1 g/cm3 |
|---|---|
| Boiling Point | 334.1±17.0 °C at 760 mmHg |
| Melting Point | 24 °C(lit.) |
| Molecular Formula | C13H11NO2 |
| Molecular Weight | 213.232 |
| Flash Point | 155.8±20.9 °C |
| Exact Mass | 213.078979 |
| PSA | 39.19000 |
| LogP | 2.65 |
| Vapour Pressure | 0.0±0.7 mmHg at 25°C |
| Index of Refraction | 1.583 |
| InChIKey | KVYGGMBOZFWZBQ-UHFFFAOYSA-N |
| SMILES | O=C(OCc1ccccc1)c1cccnc1 |
| Storage condition | 2~8℃ |
Toxicological Information
CHEMICAL IDENTIFICATION |
ACUTE TOXICITY DATA - TYPE OF TEST :
- LD50 - Lethal dose, 50 percent kill
- ROUTE OF EXPOSURE :
- Oral
- SPECIES OBSERVED :
- Rodent - mouse
- DOSE/DURATION :
- 2188 mg/kg
- TOXIC EFFECTS :
- Details of toxic effects not reported other than lethal dose value
- REFERENCE :
- BCTKAG Bromatologia i Chemia Toksykologiczna. (Ars Polona, POB 1001, 00-068 Warsaw 1, Poland) V.4- 1971- Volume(issue)/page/year: 12,79,1979
- TYPE OF TEST :
- LD50 - Lethal dose, 50 percent kill
- ROUTE OF EXPOSURE :
- Intravenous
- SPECIES OBSERVED :
- Rodent - mouse
- DOSE/DURATION :
- 100 mg/kg
- TOXIC EFFECTS :
- Details of toxic effects not reported other than lethal dose value
- REFERENCE :
- PHARAT Pharmazie. (VEB Verlag Volk und Gesundheit, Neue Gruenstr. 18, Berlin DDR-1020, Ger. Dem. Rep.) V.1- 1946- Volume(issue)/page/year: 11,242,1956
Safety Information
| Symbol | GHS07 |
|---|---|
| Signal Word | Warning |
| Hazard Statements | H315-H319 |
| Precautionary Statements | P305 + P351 + P338 |
| Personal Protective Equipment | dust mask type N95 (US);Eyeshields;Gloves |
| Hazard Codes | Xi:Irritant; |
| Risk Phrases | R36/38 |
| Safety Phrases | S26 |
| RIDADR | NONH for all modes of transport |
| WGK Germany | 2 |
| RTECS | QT0850000 |
| HS Code | 2933399090 |
Customs
| HS Code | 2933399090 |
|---|---|
| Summary | 2933399090. other compounds containing an unfused pyridine ring (whether or not hydrogenated) in the structure. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:20.0% |
Articles19
More Articles| Effects of water activity and low molecular weight humectants on skin permeability and hydration dynamics - a double-blind, randomized and controlled study. Int. J. Cosmet. Sci. 36(5) , 412-8, (2014) The mammalian skin is a barrier that effectively separates the water-rich interior of the body from the normally dryer exterior. Changes in the external conditions, for example ambient humidity, have ... | |
| [On interactions of drugs on and in the skin/comparative studies on the mutual influences of ethyleneglycol-monosalicylate and benzylnicotinate (author's transl)]. Derm. Beruf Umwelt. 29(6) , 161-7, (1981) Three radioactively marked substances (on the basis of a carbopol gel, 80% water - isopropanol) were analyzed comparatively in regard to the penetration of ethyleneglycolmonosalicylate and benzylnicot... | |
| Kinetics of blood flow after topical application of benzyl nicotinate on different anatomic sites. Arch. Dermatol. Res. 298(6) , 291-300, (2006) Cutaneous characteristics, e.g., thickness of the SC and density of follicles, affect the penetration of topically applied substances. In the present study, the penetration of benzyl nicotinate, causi... |
Synonyms
| Pyridine-3-carboxylic Acid Benzyl Ester |
| Pyridine-b-carboxylic Acid Benzyl Ester |
| Benzyl nicotinate |
| Benzyl nicotinate (JAN) |
| benzyl pyridine-3-carboxylate |
| MFCD00023584 |
| 3-Pyridinecarboxylic acid, phenylmethyl ester |
| nicotinic acid benzyl ester |
| 3-Pyridinecarboxylic acid phenylmethyl ester |
| EINECS 202-332-3 |
