CAS 66-71-7|1,10-Phenanthroline
Introduction：Basic information about CAS 66-71-7|1,10-Phenanthroline, including its chemical name, molecular formula, synonyms, physicochemical properties, and safety information, etc.
| Common Name | 1,10-Phenanthroline | ||
|---|---|---|---|
| CAS Number | 66-71-7 | Molecular Weight | 180.205 |
| Density | 1.3±0.1 g/cm3 | Boiling Point | 365.1±15.0 °C at 760 mmHg |
| Molecular Formula | C12H8N2 | Melting Point | 114-117 °C(lit.) |
| MSDS | ChineseUSA | Flash Point | 164.8±11.7 °C |
| Symbol | GHS06, GHS09 | Signal Word | Danger |
Names
| Name | 1,10-phenanthroline |
|---|---|
| Synonym | More Synonyms |
1,10-Phenanthroline BiologicalActivity
| Description | o-Phenanthroline (1,10-Phenanthroline), a metal chelator, prevents the induction of chromosomal aberrations in streptozotocin-treated cells. o-Phenanthroline (1,10-Phenanthroline) forms a red chelate with Fe2+ that absorbs maximally at 510 nm[1]. |
|---|---|
| Related Catalog | Research Areas >>OthersSignaling Pathways >>Others >>Others |
| References | [1]. Guan NanMu, et al. Synergistic inhibition between o-phenanthroline and chloride ion on cold rolled steel corrosion in phosphoric acid. Materials Chemistry and Physics Volume 86, Issue 1, 15 July 2004, Pages 59-68. |
Chemical & Physical Properties
| Density | 1.3±0.1 g/cm3 |
|---|---|
| Boiling Point | 365.1±15.0 °C at 760 mmHg |
| Melting Point | 114-117 °C(lit.) |
| Molecular Formula | C12H8N2 |
| Molecular Weight | 180.205 |
| Flash Point | 164.8±11.7 °C |
| Exact Mass | 180.068741 |
| PSA | 25.78000 |
| LogP | 1.78 |
| Vapour Pressure | 0.0±0.8 mmHg at 25°C |
| Index of Refraction | 1.740 |
| InChIKey | DGEZNRSVGBDHLK-UHFFFAOYSA-N |
| SMILES | c1cnc2c(c1)ccc1cccnc12 |
| Storage condition | Refrigerator |
| Stability | Stable. Hygroscopic. Store under nitrogen. Incompatible with strong acids, strong oxidizing agents. |
| Water Solubility | slightly soluble |
Toxicological Information
CHEMICAL IDENTIFICATION |
ACUTE TOXICITY DATA - TYPE OF TEST :
- LD50 - Lethal dose, 50 percent kill
- ROUTE OF EXPOSURE :
- Intraperitoneal
- SPECIES OBSERVED :
- Rodent - mouse
- DOSE/DURATION :
- 75 mg/kg
- TOXIC EFFECTS :
- Kidney, Ureter, Bladder - other changes in urine composition Kidney, Ureter, Bladder - other changes
- TYPE OF TEST :
- LD50 - Lethal dose, 50 percent kill
- ROUTE OF EXPOSURE :
- Intravenous
- SPECIES OBSERVED :
- Rodent - mouse
- DOSE/DURATION :
- 18 mg/kg
- TOXIC EFFECTS :
- Details of toxic effects not reported other than lethal dose value
- TYPE OF TEST :
- TDLo - Lowest published toxic dose
- ROUTE OF EXPOSURE :
- Intraperitoneal
- DOSE :
- 30 mg/kg
- SEX/DURATION :
- female 8 day(s) after conception
- TOXIC EFFECTS :
- Reproductive - Specific Developmental Abnormalities - musculoskeletal system
MUTATION DATA - TYPE OF TEST :
- DNA inhibition
- TEST SYSTEM :
- Human Leukocyte
- DOSE/DURATION :
- 5 mg/L
- REFERENCE :
- ONCOBS Oncology. (S. Karger AG, Postfach CH-4009 Basel, Switzerland) V.21- 1967- Volume(issue)/page/year: 46,193,1989 *** NIOSH STANDARDS DEVELOPMENT AND SURVEILLANCE DATA *** NIOSH OCCUPATIONAL EXPOSURE SURVEY DATA : NOHS - National Occupational Hazard Survey (1974) NOHS Hazard Code - 82276 No. of Facilities: 1002 (estimated) No. of Industries: 12 No. of Occupations: 11 No. of Employees: 8324 (estimated) NOES - National Occupational Exposure Survey (1983) NOES Hazard Code - 82276 No. of Facilities: 2265 (estimated) No. of Industries: 33 No. of Occupations: 35 No. of Employees: 40330 (estimated) No. of Female Employees: 2577 (estimated)
- TYPE OF TEST :
- DNA inhibition
- TEST SYSTEM :
- Human Leukocyte
- DOSE/DURATION :
- 5 mg/L
- REFERENCE :
- ONCOBS Oncology. (S. Karger AG, Postfach CH-4009 Basel, Switzerland) V.21- 1967- Volume(issue)/page/year: 46,193,1989 *** NIOSH STANDARDS DEVELOPMENT AND SURVEILLANCE DATA *** NIOSH OCCUPATIONAL EXPOSURE SURVEY DATA : NOHS - National Occupational Hazard Survey (1974) NOHS Hazard Code - 82276 No. of Facilities: 1002 (estimated) No. of Industries: 12 No. of Occupations: 11 No. of Employees: 8324 (estimated) NOES - National Occupational Exposure Survey (1983) NOES Hazard Code - 82276 No. of Facilities: 2265 (estimated) No. of Industries: 33 No. of Occupations: 35 No. of Employees: 40330 (estimated) No. of Female Employees: 2577 (estimated)
Safety Information
| Symbol | GHS06, GHS09 |
|---|---|
| Signal Word | Danger |
| Hazard Statements | H301-H410 |
| Precautionary Statements | P273-P301 + P310-P501 |
| Personal Protective Equipment | Eyeshields;Faceshields;Gloves;type P2 (EN 143) respirator cartridges |
| Hazard Codes | T:Toxic |
| Risk Phrases | R25;R50/53 |
| Safety Phrases | S45-S60-S61 |
| RIDADR | UN 2811 6.1/PG 3 |
| WGK Germany | 3 |
| RTECS | SF8437000 |
| Packaging Group | III |
| Hazard Class | 6.1 |
| HS Code | 29339990 |
Customs
| HS Code | 2933990090 |
|---|---|
| Summary | 2933990090. heterocyclic compounds with nitrogen hetero-atom(s) only. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:20.0% |
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Synonyms
| 1,10-Phenanthroline |
| 4,5-Diazaphenanthrene |
| 4,5-Phenanthroline |
| ORTHOPHENANTHROLINE |
| EINECS 200-629-2 |
| 1,10-o-Phenanthroline |
| o-Phenanthroline |
| β-Phenanthroline |
| 1,10-Fenanthroline |
| phenanthroline |
| MFCD00011678 |
| 1,10-Fenanthrolin |
| phen |
| 10-Phenanthroline |
| T B666 CN NNJ |
