CAS 76-22-2|(+/-)-Camphor
| Common Name | (+/-)-Camphor | ||
|---|---|---|---|
| CAS Number | 76-22-2 | Molecular Weight | 152.233 |
| Density | 1.0±0.1 g/cm3 | Boiling Point | 207.4±0.0 °C at 760 mmHg |
| Molecular Formula | C10H16O | Melting Point | 175-177 °C(lit.) |
| MSDS | ChineseUSA | Flash Point | 64.4±0.0 °C |
| Symbol | GHS02, GHS07, GHS08 | Signal Word | Warning |
Names
| Name | camphor |
|---|---|
| Synonym | More Synonyms |
(+/-)-Camphor BiologicalActivity
| Description | Camphor ((±)-Camphor) is a topical anti-infective and anti-pruritic and internally as a stimulant and carminative. However, Camphor is poisonous when ingested. Antiviral, antitussive, and anticancer activities[1]. Camphor is a TRPV3 agonist[2]. |
|---|---|
| Related Catalog | Signaling Pathways >>Membrane Transporter/Ion Channel >>TRP ChannelNatural Products >>Terpenoids and GlycosidesResearch Areas >>CancerResearch Areas >>Inflammation/ImmunologyResearch Areas >>Infection |
| Target | TRPV3[2] |
| In Vitro | Camphor induces fibroblast proliferation through the PI3K/AKT and ERK signaling pathways. The MTT assay results show that 32.5, 65, 130, and 260 μM Camphor increase fibroblast viability to 108.9±6.6%, 118.6±2.8%, 127.7±4.2%, and 131.6±7.2%, respectively, compared to 0 μM Camphor treatment. Camphor treatment for 24 h increases the generation of ROS by up to 17.97% compared to 5.04% in the no-treatment control[3]. |
| Cell Assay | Primary dermal fibroblast (2×104 cells/mL) cells are plated in 96-well plates in 200μL of medium containing 10% FBS. After 24 h, the cells are treated with various concentrations of chamomile hydrosol or Camphor (0-260 μM). After treatment, 20 μL of MTT solution (5mg/mL) is added to each well, followed by incubation in a humidified environment for 3-4 h. The supernatant is removed and 150 μL of DMSO is added. Cell viability is determined from the absorbance at 570 nm, measured using a Sunrise microplate reader[3]. |
| References | [1]. Chen W, et al. Camphor--a fumigant during the Black Death and a coveted fragrant wood in ancient Egypt and Babylon--a review. Molecules. 2013 May 10;18(5):5434-54. [2]. Billen B, et al. Different ligands of the TRPV3 cation channel cause distinct conformational changes as revealedby intrinsic tryptophan fluorescence quenching. J Biol Chem. 2015 May 15;290(20):12964-74. [3]. Tran TA, et al. Camphor Induces Proliferative and Anti-senescence Activities in Human Primary Dermal Fibroblasts and Inhibits UV-Induced Wrinkle Formation in Mouse Skin. Phytother Res. 2015 Dec;29(12):1917-25. |
Chemical & Physical Properties
| Density | 1.0±0.1 g/cm3 |
|---|---|
| Boiling Point | 207.4±0.0 °C at 760 mmHg |
| Melting Point | 175-177 °C(lit.) |
| Molecular Formula | C10H16O |
| Molecular Weight | 152.233 |
| Flash Point | 64.4±0.0 °C |
| Exact Mass | 152.120117 |
| PSA | 17.07000 |
| LogP | 2.13 |
| Vapour density | 5.2 (vs air) |
| Vapour Pressure | 0.2±0.4 mmHg at 25°C |
| Index of Refraction | 1.485 |
| InChIKey | DSSYKIVIOFKYAU-UHFFFAOYSA-N |
| SMILES | CC12CCC(CC1=O)C2(C)C |
| Stability | Stable. Combustible. Incompatible with strong oxidizing agents, metallic salts, combustible materials, organics. |
| Water Solubility | 0.12 g/100 mL (25 ºC) |
Toxicological Information
CHEMICAL IDENTIFICATION |
ACUTE TOXICITY DATA - TYPE OF TEST :
- LDLo - Lowest published lethal dose
- ROUTE OF EXPOSURE :
- Oral
- SPECIES OBSERVED :
- Human - infant
- DOSE/DURATION :
- 70 mg/kg
- TOXIC EFFECTS :
- Sense Organs and Special Senses (Eye) - mydriasis (pupillary dilation) Behavioral - convulsions or effect on seizure threshold Gastrointestinal - changes in structure or function of salivary glands
- TYPE OF TEST :
- TDLo - Lowest published toxic dose
- ROUTE OF EXPOSURE :
- Oral
- SPECIES OBSERVED :
- Human - child
- DOSE/DURATION :
- 51 mg/kg
- TOXIC EFFECTS :
- Behavioral - somnolence (general depressed activity) Behavioral - convulsions or effect on seizure threshold
- TYPE OF TEST :
- LDLo - Lowest published lethal dose
- ROUTE OF EXPOSURE :
- Unreported
- SPECIES OBSERVED :
- Human - child
- DOSE/DURATION :
- 100 mg/kg
- TOXIC EFFECTS :
- Details of toxic effects not reported other than lethal dose value
- TYPE OF TEST :
- LDLo - Lowest published lethal dose
- ROUTE OF EXPOSURE :
- Unreported
- SPECIES OBSERVED :
- Human - man
- DOSE/DURATION :
- 29 mg/kg
- TOXIC EFFECTS :
- Details of toxic effects not reported other than lethal dose value
- TYPE OF TEST :
- LDLo - Lowest published lethal dose
- ROUTE OF EXPOSURE :
- Intraperitoneal
- SPECIES OBSERVED :
- Rodent - rat
- DOSE/DURATION :
- 900 mg/kg
- TOXIC EFFECTS :
- Behavioral - convulsions or effect on seizure threshold
- TYPE OF TEST :
- LD50 - Lethal dose, 50 percent kill
- ROUTE OF EXPOSURE :
- Subcutaneous
- SPECIES OBSERVED :
- Rodent - rat
- DOSE/DURATION :
- 70 mg/kg
- TOXIC EFFECTS :
- Details of toxic effects not reported other than lethal dose value
- TYPE OF TEST :
- LD50 - Lethal dose, 50 percent kill
- ROUTE OF EXPOSURE :
- Oral
- SPECIES OBSERVED :
- Rodent - mouse
- DOSE/DURATION :
- 1310 mg/kg
- TOXIC EFFECTS :
- Details of toxic effects not reported other than lethal dose value
- TYPE OF TEST :
- LCLo - Lowest published lethal concentration
- ROUTE OF EXPOSURE :
- Inhalation
- SPECIES OBSERVED :
- Rodent - mouse
- DOSE/DURATION :
- 400 mg/m3/3H
- TOXIC EFFECTS :
- Behavioral - muscle contraction or spasticity
- TYPE OF TEST :
- LD50 - Lethal dose, 50 percent kill
- ROUTE OF EXPOSURE :
- Intraperitoneal
- SPECIES OBSERVED :
- Rodent - mouse
- DOSE/DURATION :
- 3 gm/kg
- TOXIC EFFECTS :
- Behavioral - convulsions or effect on seizure threshold Behavioral - changes in motor activity (specific assay) Behavioral - rigidity (including catalepsy)
- TYPE OF TEST :
- LDLo - Lowest published lethal dose
- ROUTE OF EXPOSURE :
- Subcutaneous
- SPECIES OBSERVED :
- Rodent - mouse
- DOSE/DURATION :
- 200 mg/kg
- TOXIC EFFECTS :
- Behavioral - excitement
- TYPE OF TEST :
- LDLo - Lowest published lethal dose
- ROUTE OF EXPOSURE :
- Oral
- SPECIES OBSERVED :
- Mammal - dog
- DOSE/DURATION :
- 800 mg/kg
- TOXIC EFFECTS :
- Details of toxic effects not reported other than lethal dose value
- TYPE OF TEST :
- LDLo - Lowest published lethal dose
- ROUTE OF EXPOSURE :
- Intraperitoneal
- SPECIES OBSERVED :
- Mammal - cat
- DOSE/DURATION :
- 400 mg/kg
- TOXIC EFFECTS :
- Details of toxic effects not reported other than lethal dose value
- TYPE OF TEST :
- LDLo - Lowest published lethal dose
- ROUTE OF EXPOSURE :
- Oral
- SPECIES OBSERVED :
- Rodent - rabbit
- DOSE/DURATION :
- 2 gm/kg
- TOXIC EFFECTS :
- Behavioral - convulsions or effect on seizure threshold Behavioral - changes in motor activity (specific assay) Behavioral - rigidity (including catalepsy)
- TYPE OF TEST :
- LDLo - Lowest published lethal dose
- ROUTE OF EXPOSURE :
- Subcutaneous
- SPECIES OBSERVED :
- Amphibian - frog
- DOSE/DURATION :
- 240 mg/kg
- TOXIC EFFECTS :
- Peripheral Nerve and Sensation - spastic paralysis with or without sensory change
- TYPE OF TEST :
- TCLo - Lowest published toxic concentration
- ROUTE OF EXPOSURE :
- Inhalation
- SPECIES OBSERVED :
- Rodent - mouse
- DOSE/DURATION :
- 210 mg/m3/3H/7W-I
- TOXIC EFFECTS :
- Lungs, Thorax, or Respiration - emphysema
- TYPE OF TEST :
- TCLo - Lowest published toxic concentration
- ROUTE OF EXPOSURE :
- Inhalation
- SPECIES OBSERVED :
- Rodent - rabbit
- DOSE/DURATION :
- 33 mg/m3/3H/7W-I
- TOXIC EFFECTS :
- Brain and Coverings - other degenerative changes Cardiac - other changes Lungs, Thorax, or Respiration - emphysema
MUTATION DATA - TEST SYSTEM :
- Rodent - mouse
- REFERENCE :
- MUREAV Mutation Research. (Elsevier Science Pub. B.V., POB 211, 1000 AE Amsterdam, Netherlands) V.1- 1964- Volume(issue)/page/year: 224,157,1989 *** REVIEWS *** ACGIH TLV-Not classifiable as a human carcinogen DTLVS* The Threshold Limit Values (TLVs) and Biological Exposure Indices (BEIs) booklet issues by American Conference of Governmental Industrial Hygienists (ACGIH), Cincinnati, OH, 1996 Volume(issue)/page/year: TLV/BEI,1997 ACGIH TLV-STEL 19 mg/m3 (3 ppm) DTLVS* The Threshold Limit Values (TLVs) and Biological Exposure Indices (BEIs) booklet issues by American Conference of Governmental Industrial Hygienists (ACGIH), Cincinnati, OH, 1996 Volume(issue)/page/year: TLV/BEI,1997 ACGIH TLV-TWA 12 mg/m3 (2 ppm) DTLVS* The Threshold Limit Values (TLVs) and Biological Exposure Indices (BEIs) booklet issues by American Conference of Governmental Industrial Hygienists (ACGIH), Cincinnati, OH, 1996 Volume(issue)/page/year: TLV/BEI,1997 TOXICOLOGY REVIEW JRPMAP Journal of Reproductive Medicine. (2 Jacklynn Ct., St. Louis, MO 63132) V.3- 1969- Volume(issue)/page/year: 12,27,1974 TOXICOLOGY REVIEW NTIS** National Technical Information Service. (Springfield, VA 22161) Formerly U.S. Clearinghouse for Scientific & Technical Information. Volume(issue)/page/year: PB293-503 *** U.S. STANDARDS AND REGULATIONS *** EPA FIFRA 1988 PESTICIDE SUBJECT TO REGISTRATION OR RE-REGISTRATION FEREAC Federal Register. (U.S. Government Printing Office, Supt. of Documents, Washington, DC 20402) V.1- 1936- Volume(issue)/page/year: 54,7740,1989 MSHA STANDARD-air:TWA 2 ppm (12 mg/m3) DTLVS* The Threshold Limit Values (TLVs) and Biological Exposure Indices (BEIs) booklet issues by American Conference of Governmental Industrial Hygienists (ACGIH), Cincinnati, OH, 1996 Volume(issue)/page/year: 3,37,1971 OSHA PEL (Gen Indu):8H TWA 2 mg/m3 CFRGBR Code of Federal Regulations. (U.S. Government Printing Office, Supt. of Documents, Washington, DC 20402) Volume(issue)/page/year: 29,1910.1000,1994 OSHA PEL (Construc):8H TWA 2 mg/m3 CFRGBR Code of Federal Regulations. (U.S. Government Printing Office, Supt. of Documents, Washington, DC 20402) Volume(issue)/page/year: 29,1926.55,1994 OSHA PEL (Shipyard):8H TWA 2 mg/m3 CFRGBR Code of Federal Regulations. (U.S. Government Printing Office, Supt. of Documents, Washington, DC 20402) Volume(issue)/page/year: 29,1915.1000,1993 OSHA PEL (Fed Cont):8H TWA 2 mg/m3 CFRGBR Code of Federal Regulations. (U.S. Government Printing Office, Supt. of Documents, Washington, DC 20402) Volume(issue)/page/year: 41,50-204.50,1994 *** OCCUPATIONAL EXPOSURE LIMITS *** OEL-AUSTRALIA:TWA 2 ppm (12 mg/m3);STEL 3 ppm (18 mg/m3) JAN 1993 OEL-AUSTRIA:TWA 2 ppm (13 mg/m3) JAN 1993 OEL-BELGIUM:TWA 2 ppm (12 mg/m3);STEL 3 ppm (19 mg/m3) JAN 1993 OEL-DENMARK:TWA 2 ppm (12 mg/m3) JAN 1993 OEL-FINLAND:TWA 0.3 ppm (2 mg/m3);STEL 0.9 ppm (6 mg/m3) JAN 1993 OEL-FRANCE:TWA 2 ppm (12 mg/m3) JAN 1993 OEL-GERMANY:TWA 2 ppm (13 mg/m3) JAN 1993 OEL-THE NETHERLANDS:TWA 2 ppm (12 mg/m3) JAN 1993 OEL-THE PHILIPPINES:TWA 2 ppm (12 mg/m3) JAN 1993 OEL-RUSSIA:STEL 3 mg/m3 JAN 1993 OEL-SWITZERLAND:TWA 2 ppm (13 mg/m3) JAN 1993 OEL-UNITED KINGDOM:TWA 2 ppm (12 mg/m3);STEL 3 ppm (18 mg/m3) JAN 1993 OEL IN BULGARIA, COLOMBIA, JORDAN, KOREA check ACGIH TLV OEL IN NEW ZEALAND, SINGAPORE, VIETNAM check ACGIH TLV *** NIOSH STANDARDS DEVELOPMENT AND SURVEILLANCE DATA *** NIOSH RECOMMENDED EXPOSURE LEVEL (REL) : NIOSH REL TO CAMPHOR, synthetic-air:10H TWA 2 mg/m3 REFERENCE : NIOSH* National Institute for Occupational Safety and Health, U.S. Dept. of Health, Education, and Welfare, Reports and Memoranda. Volume(issue)/page/year: DHHS #92-100,1992 NIOSH OCCUPATIONAL EXPOSURE SURVEY DATA : NOHS - National Occupational Hazard Survey (1974) NOHS Hazard Code - 15800 No. of Facilities: 8356 (estimated) No. of Industries: 68 No. of Occupations: 63 No. of Employees: 95578 (estimated) NOES - National Occupational Exposure Survey (1983) NOES Hazard Code - X1190 No. of Facilities: 25 (estimated) No. of Industries: 1 No. of Occupations: 1 No. of Employees: 427 (estimated) No. of Female Employees: 176 (estimated) NOES - National Occupational Exposure Survey (1983) NOES Hazard Code - 15800 No. of Facilities: 9166 (estimated) No. of Industries: 101 No. of Occupations: 87 No. of Employees: 153554 (estimated) No. of Female Employees: 53187 (estimated)
- TEST SYSTEM :
- Rodent - mouse
- REFERENCE :
- MUREAV Mutation Research. (Elsevier Science Pub. B.V., POB 211, 1000 AE Amsterdam, Netherlands) V.1- 1964- Volume(issue)/page/year: 224,157,1989 *** REVIEWS *** ACGIH TLV-Not classifiable as a human carcinogen DTLVS* The Threshold Limit Values (TLVs) and Biological Exposure Indices (BEIs) booklet issues by American Conference of Governmental Industrial Hygienists (ACGIH), Cincinnati, OH, 1996 Volume(issue)/page/year: TLV/BEI,1997 ACGIH TLV-STEL 19 mg/m3 (3 ppm) DTLVS* The Threshold Limit Values (TLVs) and Biological Exposure Indices (BEIs) booklet issues by American Conference of Governmental Industrial Hygienists (ACGIH), Cincinnati, OH, 1996 Volume(issue)/page/year: TLV/BEI,1997 ACGIH TLV-TWA 12 mg/m3 (2 ppm) DTLVS* The Threshold Limit Values (TLVs) and Biological Exposure Indices (BEIs) booklet issues by American Conference of Governmental Industrial Hygienists (ACGIH), Cincinnati, OH, 1996 Volume(issue)/page/year: TLV/BEI,1997 TOXICOLOGY REVIEW JRPMAP Journal of Reproductive Medicine. (2 Jacklynn Ct., St. Louis, MO 63132) V.3- 1969- Volume(issue)/page/year: 12,27,1974 TOXICOLOGY REVIEW NTIS** National Technical Information Service. (Springfield, VA 22161) Formerly U.S. Clearinghouse for Scientific & Technical Information. Volume(issue)/page/year: PB293-503 *** U.S. STANDARDS AND REGULATIONS *** EPA FIFRA 1988 PESTICIDE SUBJECT TO REGISTRATION OR RE-REGISTRATION FEREAC Federal Register. (U.S. Government Printing Office, Supt. of Documents, Washington, DC 20402) V.1- 1936- Volume(issue)/page/year: 54,7740,1989 MSHA STANDARD-air:TWA 2 ppm (12 mg/m3) DTLVS* The Threshold Limit Values (TLVs) and Biological Exposure Indices (BEIs) booklet issues by American Conference of Governmental Industrial Hygienists (ACGIH), Cincinnati, OH, 1996 Volume(issue)/page/year: 3,37,1971 OSHA PEL (Gen Indu):8H TWA 2 mg/m3 CFRGBR Code of Federal Regulations. (U.S. Government Printing Office, Supt. of Documents, Washington, DC 20402) Volume(issue)/page/year: 29,1910.1000,1994 OSHA PEL (Construc):8H TWA 2 mg/m3 CFRGBR Code of Federal Regulations. (U.S. Government Printing Office, Supt. of Documents, Washington, DC 20402) Volume(issue)/page/year: 29,1926.55,1994 OSHA PEL (Shipyard):8H TWA 2 mg/m3 CFRGBR Code of Federal Regulations. (U.S. Government Printing Office, Supt. of Documents, Washington, DC 20402) Volume(issue)/page/year: 29,1915.1000,1993 OSHA PEL (Fed Cont):8H TWA 2 mg/m3 CFRGBR Code of Federal Regulations. (U.S. Government Printing Office, Supt. of Documents, Washington, DC 20402) Volume(issue)/page/year: 41,50-204.50,1994 *** OCCUPATIONAL EXPOSURE LIMITS *** OEL-AUSTRALIA:TWA 2 ppm (12 mg/m3);STEL 3 ppm (18 mg/m3) JAN 1993 OEL-AUSTRIA:TWA 2 ppm (13 mg/m3) JAN 1993 OEL-BELGIUM:TWA 2 ppm (12 mg/m3);STEL 3 ppm (19 mg/m3) JAN 1993 OEL-DENMARK:TWA 2 ppm (12 mg/m3) JAN 1993 OEL-FINLAND:TWA 0.3 ppm (2 mg/m3);STEL 0.9 ppm (6 mg/m3) JAN 1993 OEL-FRANCE:TWA 2 ppm (12 mg/m3) JAN 1993 OEL-GERMANY:TWA 2 ppm (13 mg/m3) JAN 1993 OEL-THE NETHERLANDS:TWA 2 ppm (12 mg/m3) JAN 1993 OEL-THE PHILIPPINES:TWA 2 ppm (12 mg/m3) JAN 1993 OEL-RUSSIA:STEL 3 mg/m3 JAN 1993 OEL-SWITZERLAND:TWA 2 ppm (13 mg/m3) JAN 1993 OEL-UNITED KINGDOM:TWA 2 ppm (12 mg/m3);STEL 3 ppm (18 mg/m3) JAN 1993 OEL IN BULGARIA, COLOMBIA, JORDAN, KOREA check ACGIH TLV OEL IN NEW ZEALAND, SINGAPORE, VIETNAM check ACGIH TLV *** NIOSH STANDARDS DEVELOPMENT AND SURVEILLANCE DATA *** NIOSH RECOMMENDED EXPOSURE LEVEL (REL) : NIOSH REL TO CAMPHOR, synthetic-air:10H TWA 2 mg/m3 REFERENCE : NIOSH* National Institute for Occupational Safety and Health, U.S. Dept. of Health, Education, and Welfare, Reports and Memoranda. Volume(issue)/page/year: DHHS #92-100,1992 NIOSH OCCUPATIONAL EXPOSURE SURVEY DATA : NOHS - National Occupational Hazard Survey (1974) NOHS Hazard Code - 15800 No. of Facilities: 8356 (estimated) No. of Industries: 68 No. of Occupations: 63 No. of Employees: 95578 (estimated) NOES - National Occupational Exposure Survey (1983) NOES Hazard Code - X1190 No. of Facilities: 25 (estimated) No. of Industries: 1 No. of Occupations: 1 No. of Employees: 427 (estimated) No. of Female Employees: 176 (estimated) NOES - National Occupational Exposure Survey (1983) NOES Hazard Code - 15800 No. of Facilities: 9166 (estimated) No. of Industries: 101 No. of Occupations: 87 No. of Employees: 153554 (estimated) No. of Female Employees: 53187 (estimated)
Safety Information
| Symbol | GHS02, GHS07, GHS08 |
|---|---|
| Signal Word | Warning |
| Hazard Statements | H228-H302 + H332-H371 |
| Precautionary Statements | P210-P260-P301 + P312 + P330-P370 + P378 |
| Target Organs | Lungs |
| Personal Protective Equipment | dust mask type N95 (US);Eyeshields;full-face particle respirator type N100 (US);Gloves;respirator cartridge type N100 (US);type P1 (EN143) respirator filter;type P3 (EN 143) respirator cartridges |
| Hazard Codes | F:Flammable |
| Risk Phrases | R11;R36/37/38 |
| Safety Phrases | S16-S26-S37/39 |
| RIDADR | UN 2717 4.1/PG 3 |
| WGK Germany | 1 |
| RTECS | EX1225000 |
| Packaging Group | III |
| Hazard Class | 4.1 |
| HS Code | 2914291000 |
Customs
| HS Code | 2914291000 |
|---|
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Synonyms
| (+)-bornan-2-one |
| Bicyclo(2.2.1)heptan-2-one, 1,7,7-trimethyl- |
| camphanone |
| 3-Fluor-2,2-dimethyl-bicyclo<2.2.1>heptan |
| (1S,4S)-1,7,7-Trimethylbicyclo[2.2.1]heptan-2-one |
| 1,7,7-Trimethylbicyclo[2.2.1]-2-heptanone |
| 2-Kamfanon |
| D-CAMPHOR |
| (±)-bornan-2-one |
| 2-Oxo-bornan |
| 2-Bornanone,2-Camphanone,D-Camphor |
| Radian B |
| lphanon |
| DL-2-Bornanone |
| D-(+)-Camphor |
| MFCD00676613 |
| Alphanon |
| L(-)-Camphor |
| 1,7,7-Trimethylbicyclo[2.2.1]heptan-2-one |
| DL-Camphor |
| Camphen-hydrofluorid |
| (1RS,4RS)-1,7,7-trimethylbicyclo[2.2.1]heptan-2-one |
| Caladryl |
| (-)-Camphor |
| 2-Keto-1,7,7-trimethylnolcamphane |
| Bicyclo[2.2.1]heptan-2-one, 1,7,7-trimethyl- |
| (−)-Camphor,(1S)-1,7,7-Trimethylbicyclo[2.2.1]heptan-2-one |
| 2-CAMPHOR |
| EINECS 200-945-0 |
| (±)-Camphor |
| 2-Camphonone |
| Dehydrocamphor |
| Camphor |
| (+)-CaMphor |
| (1R,4R)-1,7,7-trimethylbicyclo[2.2.1]heptan-2-one |
| 2-Bornanone,2-Camphanone |
| D(+)-Camphor |
| 2-Bornanone 2-Camphanone |
| Kampfer |
| (+)-Camphor,(1R)-1,7,7-Trimethylbicyclo[2.2.1]heptan-2-one |
| camphre |
| (1S)-1,7,7-Trimethylbicyclo[2.2.1]heptan-2-one |
