CAS 76932-56-4|(D-2-Nal6)-LHRH acetate salt

Introduction：Basic information about CAS 76932-56-4|(D-2-Nal6)-LHRH acetate salt, including its chemical name, molecular formula, synonyms, physicochemical properties, and safety information, etc.

Table of Contents

1. Names
2. (D-2-Nal6)-LHRH acetate salt BiologicalActivity
3. Chemical & Physical Properties
4. Toxicological Information
CHEMICAL IDENTIFICATION
HEALTH HAZARD DATA
ACUTE TOXICITY DATA
5. Synonyms

Common Name	(D-2-Nal6)-LHRH acetate salt
CAS Number	76932-56-4	Molecular Weight	1322.471
Density	1.5±0.1 g/cm3	Boiling Point	/
Molecular Formula	C₆₆H₈₃N₁₇O₁₃	Melting Point	/
MSDS	/	Flash Point	/

Names

Name	Nafarelin
Synonym	More Synonyms

(D-2-Nal6)-LHRH acetate salt BiologicalActivity

Description	Nafarelin is a gonadotropin-releasing hormone (GnRH) agonist that stimulates secretion of luteinizing hormone (LH) and follicle-stimulating hormone (FSH). Sequence: {Glp}-His-Trp-Ser-Tyr-{2-Naph-Ala}-Leu-Arg-Pro-Gly-NH2.
Related Catalog	Signaling Pathways >>GPCR/G Protein >>GNRH ReceptorPeptidesResearch Areas >>Cancer
Target	GnRH[1].
In Vitro	Nafarelin is a gonadotropin-releasing hormone (GnRH) agonist that stimulates secretion of luteinizing hormone (LH) and follicle-stimulating hormone (FSH)[1]. Nafarelin is used effectively in in vitro fertilisation programmes. Nafarelin is readily and rapidly absorbed following intranasal delivery, and is protected to some extent from enzymatic degradation GnRH[2].
References	[1]. Letassy NA et al. Nafarelin acetate: a gonadotropin-releasing hormone agonist for the treatment of endometriosis. DICP. 1990 Dec, 24(12):1204-9. [2]. Chrisp P et al. Nafarelin. A review of its pharmacodynamic and pharmacokinetic properties, and clinical potential in sex hormone-related conditions.Drugs. 1990 Apr;39(4):523-51.

Chemical & Physical Properties

Density	1.5±0.1 g/cm3
Molecular Formula	C₆₆H₈₃N₁₇O₁₃
Molecular Weight	1322.471
Exact Mass	1321.635620
PSA	472.13000
LogP	0.89
Index of Refraction	1.711
InChIKey	RWHUEXWOYVBUCI-ITQXDASVSA-N
SMILES	CC(C)CC(NC(=O)C(Cc1ccc2ccccc2c1)NC(=O)C(Cc1ccc(O)cc1)NC(=O)C(CO)NC(=O)C(Cc1c[nH]c2ccccc12)NC(=O)C(Cc1cnc[nH]1)NC(=O)C1CCC(=O)N1)C(=O)NC(CCCN=C(N)N)C(=O)N1CCCC1C(=O)NCC(N)=O
Storage condition	-20°C

Toxicological Information

CHEMICAL IDENTIFICATION

RTECS NUMBER :: OK6371150

CHEMICAL NAME :: Luteinizing hormone-releasing factor (pig), 6-(3-(2-naphthalenyl)-D-alanine)-

CAS REGISTRY NUMBER :: 76932-56-4

LAST UPDATED :: 199703

DATA ITEMS CITED :: 1

MOLECULAR FORMULA :: C66-H83-N17-O13

MOLECULAR WEIGHT :: 1322.66

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :: TDLo - Lowest published toxic dose

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Human - woman

DOSE/DURATION :: 448 ug/kg/8W-I

TOXIC EFFECTS :: Nutritional and Gross Metabolic - changes in potassium

REFERENCE :: LANCAO Lancet. (7 Adam St., London WC2N 6AD, UK) V.1- 1823- Volume(issue)/page/year: 347,333,1996

Synonyms

(2S)-N-(2-amino-2-oxoethyl)-1-{(2S,5S,8R,11S,14S,17S,20S)-2-(3-carbamimidamidopropyl)-11-(4-hydroxybenzyl)-14-(hydroxymethyl)-20-(1H-imidazol-4-ylmethyl)-17-(1H-indol-3-ylmethyl)-5-(2-methylpropyl)-8-(naphthalen-2-ylmethyl)-4,7,10,13,16,19,22-heptaoxo-22-[(2S)-5-oxopyrrolidin-2-yl]-3,6,9,12,15,18,21-heptaazadocosan-1-oyl}pyrrolidine-2-carboxamide (non-preferred name)

Nacenyl

(2S)-N-(2-Amino-2-oxoethyl)-1-{(2S,5S,8R,11S,14S,17S,20S)-2-(3-carbamimidamidopropyl)-11-(4-hydroxybenzyl)-14-(hydroxymethyl)-20-(1H-imidazol-4-ylmethyl)-17-(1H-indol-3-ylmethyl)-5-isobutyl-8-(2-naphthylmethyl)-4,7,10,13,16,19,22-heptaoxo-22-[(2S)-5-oxopyrrolidin-2-yl]-3,6,9,12,15,18,21-heptaazadocosan-1-oyl}pyrrolidine-2-carboxamide (non-preferred name)

Nafareline

UNII:1X0094V6JV

Synarel

(2S)-N-(2-Amino-2-oxoethyl)-1-{(2S,5S,8R,11S,14S,17S,20S)-2-(3-carbamimidamidopropyl)-11-(4-hydroxybenzyl)-14-(hydroxymethyl)-20-(1H-imidazol-4-ylmethyl)-17-(1H-indol-3-ylmethyl)-5-isobutyl-8-(2-naphthylmethyl)-4,7,10,13,16,19,22-heptaoxo-22-[(2S)-5-oxo-2-pyrrolidinyl]-3,6,9,12,15,18,21-heptaazadocosan-1-oyl}-2-pyrrolidinecarboxamide

6-(3-(2-Naphthalenyl)-D-alanine)luteinizing Hormone-releasing Factor

glycinamide, 5-oxo-L-prolyl-L-histidyl-L-tryptophyl-L-seryl-L-tyrosyl-3-(2-naphthalenyl)-D-alanyl-L-leucyl-L-arginyl-L-prolyl-

Synrelina

Nasanyl

Nafarelin Acetate

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