CAS 60668-24-8|Alafosfalin
| Common Name | Alafosfalin | ||
|---|---|---|---|
| CAS Number | 60668-24-8 | Molecular Weight | 196.14100 |
| Density | / | Boiling Point | / |
| Molecular Formula | C5H13N2O4P | Melting Point | / |
| MSDS | ChineseUSA | Flash Point | / |
| Symbol | GHS07 | Signal Word | Warning |
Names
| Name | (s)-alanyl-(r)-1-aminoethylphosphonic acid |
|---|---|
| Synonym | More Synonyms |
Alafosfalin BiologicalActivity
| Description | Alafosfalin is an inhibitor of cell wall biosynthesis. Alafosfalin is a phosphonodipeptide with antibacterial properties[1]. |
|---|---|
| Related Catalog | Research Areas >>InfectionSignaling Pathways >>Anti-infection >>Bacterial |
| Target | Antibacterial[1] |
| In Vitro | Alafosfalin is highly active against Escherichia coli and moderately active against Serratia, Klebsiella, Enterobacter, and Citrobacter, but less active against gram-positive organisms than were beta-lactams such as cephazolin or ampicillin and inactive against indole-positive Proteus, Pseudomonas, and Acinetobacter[1]. |
| In Vivo | After s.c. administration to rats, Alafosfalin is rapidly absorbed with half-lives (t1/2) of approximately 20 minutes[2]. Animal Model: Pairs of male SpragueDawley rats (250 to 350 g)[2] Dosage: 20, 100, and 500 mg/ kg (single doses) or 800 mg/kg per day for 14 days (Pharmacokinetic Analysis) Administration: Administrated by s.c. Result: Rapidly absorbed; peak concentrations were found within 20 minutes of dosing with half-lives of approximately 20 minutes. |
| References | [1]. H B Maruyama, et al. Alafosfalin, a New Inhibitor of Cell Wall Biosynthesis: In Vitro Activity Against Urinary Isolates in Japan and Potentiation With Beta-Lactams. Antimicrob Agents Chemother. 1979 Oct;16(4):444-51. [2]. J G Allen, et al. Phosphonopeptides as Antibacterial Agents: Metabolism and Pharmacokinetics of Alafosfalin in Animals and Humans. Antimicrob Agents Chemother. 1979 Sep;16(3):306-13. |
Chemical & Physical Properties
| Molecular Formula | C5H13N2O4P |
|---|---|
| Molecular Weight | 196.14100 |
| Exact Mass | 196.06100 |
| PSA | 125.45000 |
| LogP | 0.76750 |
| InChIKey | BHAYDBSYOBONRV-IUYQGCFVSA-N |
| SMILES | CC(N)C(=O)NC(C)P(=O)(O)O |
Safety Information
| Symbol | GHS07 |
|---|---|
| Signal Word | Warning |
| Hazard Statements | H302 |
| Personal Protective Equipment | dust mask type N95 (US);Eyeshields;Gloves |
| Hazard Codes | Xn |
| Risk Phrases | 22 |
| RIDADR | NONH for all modes of transport |
| HS Code | 2931900090 |
Customs
| HS Code | 2931900090 |
|---|---|
| Summary | 2931900090. other organo-inorganic compounds. VAT:17.0%. Tax rebate rate:13.0%. Supervision conditions:AB(certificate of inspection for goods inward,certificate of inspection for goods outward). MFN tariff:6.5%. General tariff:30.0% |
Articles21
More Articles| In vitro potentiation of cephalosporins by alafosfalin against urinary tract bacteria. Antimicrob. Agents Chemother. 21(5) , 706-10, (1982) Potentiating activity of alafosfalin was examined in detail with 8 cephalosporins and mecillinam against 164 urinary bacteria representing 8 genera. Alafosfalin was generally comparable in activity to... | |
| Alafosfalin as a selective agent for isolation of salmonella from clinical samples. J. Clin. Microbiol. 40(11) , 3913-6, (2002) The selectivity of a range of culture media for the detection of Salmonella was assessed using 435 strains of gram-negative bacteria. These media showed limited ability to inhibit non-Salmonella strai... | |
| Synergistic antibacterial activity between L-norvalyl-L-1-aminoethylphosphonic acid and nocardicin A. Antimicrob. Agents Chemother. 25(5) , 607-11, (1984) The phosphonopeptide L- norvalyl -L-1- aminoethylphosphonic acid [ Nva -Ala(P)] has been studied in combination with 12 beta-lactam antibiotics for activity against Pseudomonas aeruginosa. Nocardicin ... |
Synonyms
| (1R)-1-(L-alanylamino)-ethylphosphonic acid |
| ALAFOSFALIN |
| H-L-Ala-L-AlaP(OH)2 |
| N-(S)-alanyl-(R)-1-aminoethanephosphonic acid |
| ALAPHOSPHIN |
| L-alanyl-L-1-aminoethylphosphonic acid |
| 1R-1-(L-alanylamino)-ethanephosphonic acid |
| L-ALANYL-L-ALA(P)-OH |
| (S)-Alanyl-(R)-1-aminoethylphosphonic acid,Alafosfalin,Alaphosphin |
| ((L)-(1-((N-L-alanyl)amino)ethyl))phosphonic acid |
