CAS 5631-68-5|3-(2,4-Dihydroxyphenyl)propionic acid
| Common Name | 3-(2,4-Dihydroxyphenyl)propionic acid | ||
|---|---|---|---|
| CAS Number | 5631-68-5 | Molecular Weight | 182.173 |
| Density | 1.4±0.1 g/cm3 | Boiling Point | 418.0±14.0 °C at 760 mmHg |
| Molecular Formula | C9H10O4 | Melting Point | 158-162ºC |
| MSDS | ChineseUSA | Flash Point | 220.8±16.6 °C |
Names
| Name | 3-(2,4-Dihydroxyphenyl)propanoic acid |
|---|---|
| Synonym | More Synonyms |
3-(2,4-Dihydroxyphenyl)propionic acid BiologicalActivity
| Description | 3-(2,4-Dihydroxyphenyl)propanoic acid (DPPacid) is a potent and competitive tyrosinase inhibitor, inhibits L-Tyrosine and DL-DOPA with an IC50 and a Ki of 3.02 μM and 11.5 μM, respectively[1]. |
|---|---|
| Related Catalog | Research Areas >>OthersSignaling Pathways >>Metabolic Enzyme/Protease >>Tyrosinase |
| Target | Ki: 3.02 μM (L-Tyrosine); 11.5 μM (DL-DOPA)[1] |
| References | [1]. Shimizu K, et al. Novel vitamin E derivative with 4-substituted resorcinol moiety has both antioxidant and tyrosinase inhibitory properties. Lipids. 2001 Dec;36(12):1321-6. |
Chemical & Physical Properties
| Density | 1.4±0.1 g/cm3 |
|---|---|
| Boiling Point | 418.0±14.0 °C at 760 mmHg |
| Melting Point | 158-162ºC |
| Molecular Formula | C9H10O4 |
| Molecular Weight | 182.173 |
| Flash Point | 220.8±16.6 °C |
| Exact Mass | 182.057907 |
| PSA | 77.76000 |
| LogP | 0.38 |
| Vapour Pressure | 0.0±1.0 mmHg at 25°C |
| Index of Refraction | 1.620 |
| InChIKey | HMCMTJPPXSGYJY-UHFFFAOYSA-N |
| SMILES | O=C(O)CCc1ccc(O)cc1O |
Safety Information
| Personal Protective Equipment | Eyeshields;Gloves;type N95 (US);type P1 (EN143) respirator filter |
|---|---|
| Hazard Codes | Xi |
| Safety Phrases | S22-S24/25 |
| RIDADR | NONH for all modes of transport |
| WGK Germany | 3 |
| HS Code | 2918290000 |
Customs
| HS Code | 2918290000 |
|---|---|
| Summary | HS: 2918290000 other carboxylic acids with phenol function but without other oxygen function, their anhydrides, halides, peroxides, peroxyacids and their derivatives Tax rebate rate:9.0% Supervision conditions:AB(certificate of inspection for goods inward,certificate of inspection for goods outward) VAT:17.0% MFN tariff:6.5% General tariff:30.0% |
Articles4
More Articles| The use of enzyme-coupled magnetic nanoparticles for studying the spectra of unusual substrates of mushroom tyrosinase by direct surface-assisted laser desorption/ionisation and high-resolution electrospray ionisation quadrupole-quadrupole-time-of-flight mass spectrometry. Rapid Commun. Mass Spectrom. 28(18) , 1957-63, (2014) Tyrosinase-coupled magnetic particles (EMPs) were used to demonstrate that resorcinol-containing tyrosinase inhibitors are oxidised by tyrosinase only in the presence of the enzyme's classic substrate... | |
| The protein oxidation product 3,4-dihydroxyphenylalanine (DOPA) mediates oxidative DNA damage. Biochem. J. 330 ( Pt 3) , 1059-67, (1998) A major product of hydroxy-radical addition to tyrosine is 3, 4-dihydroxyphenylalanine (DOPA) which has reducing properties. Protein-bound DOPA (PB-DOPA) has been shown to be a major component of the ... | |
| Phenoloxidase and QX disease resistance in Sydney rock oysters (Saccostrea glomerata). Dev. Comp. Immunol. 28(6) , 565-9, (2004) QX is a fatal disease in Sydney rock oysters (Saccostrea glomerata) that results from infection by the protistan parasite, Marteilia sydneyi. Since 1997, the New South Wales Fisheries Service has bred... |
Synonyms
| 3-(2,4-Dihydroxyphenyl)propanoic acid |
| Benzenepropanoic acid, 2,4-dihydroxy- |
| MFCD00143017 |
