Introduction：Basic information about CAS 482-27-9|Isopimpinellin, including its chemical name, molecular formula, synonyms, physicochemical properties, and safety information, etc.
| Common Name | Isopimpinellin |
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| CAS Number | 482-27-9 | Molecular Weight | 246.215 |
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| Density | 1.4±0.1 g/cm3 | Boiling Point | 448.7±45.0 °C at 760 mmHg |
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| Molecular Formula | C13H10O5 | Melting Point | 150-151ºC |
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| MSDS | ChineseUSA | Flash Point | 225.1±28.7 °C |
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| Symbol |
GHS06 | Signal Word | Danger |
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Names
| Name | isopimpinellin |
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| Synonym | More Synonyms |
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Isopimpinellin BiologicalActivity
| Description | Isopimpinellin, an orally active compound isolated from the roots of Pimpinella saxifrage. Isopimpinellin blocks DNA adduct formation and skin tumor initiation by 7,12-dimethylbenz[a]anthracene. Isopimpinellin possesses anti-leishmania effect[1]. |
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| Related Catalog | Research Areas >>CancerResearch Areas >>InfectionSignaling Pathways >>Cell Cycle/DNA Damage >>DNA/RNA SynthesisResearch Areas >>Inflammation/Immunology |
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| In Vivo | Isopimpinellin (oral gavage, 35-150 mg/kg) inhibits B[a]P-DNA adduct formation and DMBA–DNA adduct formation in SENCAR mice with skin tumor[1]. Animal Model: Female SENCAR mice (7-9 weeks of age) were fed AIN-76A semi-purified diet (Dyets, Bethlehem, PA) for 2 weeks prior to and during the study[1]. Dosage: 35–150 mg/kg. Administration: Oral gavage, suspended in 0.1 mL corn oil at 24 h and 2 h prior to topical treatment with [3H]B[a]P (200 nmol, 1 Ci/mmol) or [3H]DMBA (10 nmol, 10 Ci/mmol) (each in 0.2 mL acetone). Result: Significantly inhibited B[a]P-DNA adduct formation by 37 and 26%, respectively. Isopimpinellin (35, 70 and 150 mg/kg) blocked DMBA–DNA adduct formation by 23, 56 and 69%, respectively |
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| References | [1]. Kleiner HE, et al. Oral administration of the citrus coumarin, isopimpinellin, blocks DNA adduct formation and skin tumor initiation by 7,12-dimethylbenz[a]anthracene in SENCAR mice. Carcinogenesis. 2002 Oct;23(10):1667-75. |
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Chemical & Physical Properties
| Density | 1.4±0.1 g/cm3 |
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| Boiling Point | 448.7±45.0 °C at 760 mmHg |
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| Melting Point | 150-151ºC |
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| Molecular Formula | C13H10O5 |
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| Molecular Weight | 246.215 |
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| Flash Point | 225.1±28.7 °C |
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| Exact Mass | 246.052826 |
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| PSA | 61.81000 |
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| LogP | 2.31 |
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| Vapour Pressure | 0.0±1.1 mmHg at 25°C |
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| Index of Refraction | 1.612 |
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| InChIKey | DFMAXQKDIGCMTL-UHFFFAOYSA-N |
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| SMILES | COc1c2ccoc2c(OC)c2oc(=O)ccc12 |
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| Storage condition | 2-8°C |
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Safety Information
| Symbol |
GHS06 |
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| Signal Word | Danger |
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| Hazard Statements | H300 |
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| Precautionary Statements | P264-P301 + P310 |
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| Hazard Codes | T+ |
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| Risk Phrases | 20/21/22 |
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| Safety Phrases | 22-36/37/39-45-36/37-28 |
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| RIDADR | UN 2811 6.1 / PGII |
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| RTECS | LV1049200 |
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Articles1
More Articles
| Application of the equivalency factor concept to the phototoxicity and –genotoxicity of furocoumarin mixtures Food Chem. Toxicol. 68 , 257-66, (2014) • The photo-cytotoxic, -mutagenic, and -clastogenic properties in V79 cells of thirteen furocoumarins (FCs), were analyzed. • Nine FC mixtures including one mixture ‘representing’ FCs in Angelica arch... | |
Synonyms
| 5,8-Dimethoxypsoralen |
| 4,9-Dimethoxy-furo[3,2-g]chromen-7-one |
| 4,9-Dimethoxyfuro[3,2-g]benzopyran-7-one |
| 4,9-Dimethoxy-7H-furo[3,2-g][1]benzopyran-7-one |
| 4,9-dimethoxyfuro[3,2-g]chromen-7-one |
| 4,9-Dimethoxy-7H-furo[3,2-g]chromen-7-one |
| MFCD00017407 |
| 7H-Furo[3,2-g][1]benzopyran-7-one, 4,9-dimethoxy- |
| Isopimpinellin |
