CAS 40580-59-4|guanadrel

Introduction：Basic information about CAS 40580-59-4|guanadrel, including its chemical name, molecular formula, synonyms, physicochemical properties, and safety information, etc.

Table of Contents

1. Names
2. guanadrel BiologicalActivity
3. Chemical & Physical Properties
4. Synonyms

Common Name	guanadrel
CAS Number	40580-59-4	Molecular Weight	213.27700
Density	1.39g/cm3	Boiling Point	387.9ºC at 760 mmHg
Molecular Formula	C₁₀H₁₉N₃O₂	Melting Point	213.5-215ºC
MSDS	/	Flash Point	188.4ºC

Names

Name	guanadrel
Synonym	More Synonyms

guanadrel BiologicalActivity

Description	Guanadrel is an orally active postganglionic adrenergic inhibitor of spiroketal. Guanadre can be used in anti-hypertensive studies[1].
Related Catalog	Research Areas >>Cardiovascular DiseaseSignaling Pathways >>GPCR/G Protein >>Adrenergic Receptor
In Vivo	Guanadrel (oral gavage, 15-400 mg/kg, every day, 6-52 weeks) has little toxicity to the nervous system in rats and dogs[1]. Animal Model: Rats, dogs[1] Dosage: 15-400 mg/kg Administration: Oral gavage; every day; 6-52 weeks Result: Showed a slight increase in the weight of the prostate and adrenal glands while loss in the kidney in rats. Decreased weight gain values in a dose-dependent manner but liver function is normal in dogs.
References	[1]. J D Palmer, et al. Guanadrel sulfate: a postganglionic sympathetic inhibitor for the treatment of mild to moderate hypertension. Pharmacotherapy. 1983 Jul-Aug;3(4):220-9. doi: 10.1002/j.1875-9114.1983.tb03257.x.

Chemical & Physical Properties

Density	1.39g/cm3
Boiling Point	387.9ºC at 760 mmHg
Melting Point	213.5-215ºC
Molecular Formula	C₁₀H₁₉N₃O₂
Molecular Weight	213.27700
Flash Point	188.4ºC
Exact Mass	213.14800
PSA	80.36000
LogP	1.73620
Index of Refraction	1.618
InChIKey	HPBNRIOWIXYZFK-UHFFFAOYSA-N
SMILES	NC(N)=NCC1COC2(CCCCC2)O1

Synonyms

1-(1,4-Dioxaspiro[4.5]decan-2-ylmethyl)guanidine

Guanadrel

Recommended......