CAS 101831-36-1|Clazuril
| Common Name | Clazuril | ||
|---|---|---|---|
| CAS Number | 101831-36-1 | Molecular Weight | 373.19300 |
| Density | 1.48g/cm3 | Boiling Point | / |
| Molecular Formula | C17H10Cl2N4O2 | Melting Point | 196.8° |
| MSDS | / | Flash Point | / |
Names
| Name | 2-[2-chloro-4-(3,5-dioxo-1,2,4-triazin-2-yl)phenyl]-2-(4-chlorophenyl)acetonitrile |
|---|---|
| Synonym | More Synonyms |
Clazuril BiologicalActivity
| Description | Clazuril (R62690) has a coccidiocidal effect on the asexual and sexual developmental stages of both Eimeria species, resulting in a complete interruption of the life cycle[1]. |
|---|---|
| Related Catalog | Research Areas >>Infection |
| In Vivo | Clazuril (2.5 mg/pigeon) results in a rapid suppression of oocyst excretion, but oocysts are again observed in the feces 20 days after treatment. The fact that oocysts appears again in the feces 3 to 5 weeks after treatment can probably be explained only by a persistence of endogenous stages, which are not affected during treatment, rather than by a reinfection [2]. |
| References | [1]. W Coussement, et al. Action of the anticoccidial clazuril on the endogenous stages of Eimeria labbeana and E columbarum in experimentally infected pigeons. Res Vet Sci. 1988 Jul;45(1):117-9. [2]. J Vercruysse, et al. Efficacy of toltrazuril and clazuril against experimental infections with Eimeria labbeana and E. columbarum in racing pigeons. Avian Dis. Jan-Mar 1990;34(1):73-9. |
Chemical & Physical Properties
| Density | 1.48g/cm3 |
|---|---|
| Melting Point | 196.8° |
| Molecular Formula | C17H10Cl2N4O2 |
| Molecular Weight | 373.19300 |
| Exact Mass | 372.01800 |
| PSA | 91.54000 |
| LogP | 2.88308 |
| Index of Refraction | 1.692 |
| InChIKey | QUUTUGLQZLNABV-UHFFFAOYSA-N |
| SMILES | N#CC(c1ccc(Cl)cc1)c1ccc(-n2ncc(=O)[nH]c2=O)cc1Cl |
Articles6
More Articles| Efficacy of selected coccidiostats in sandhill cranes (Grus canadensis) following challenge. J. Zoo Wildl. Med. 36(3) , 391-400, (2005) The anticoccidial efficacy of amprolium, clazuril, and monensin were studied in sandhill cranes (Grus canadensis) infected with a mixture of Eimeria spp. oocysts. Five groups of four 1-day-old sandhil... | |
| Action of the anticoccidial clazuril on the endogenous stages of Eimeria labbeana and E columbarum in experimentally infected pigeons. Res. Vet. Sci. 45(1) , 117-9, (1988) Racing pigeons were artificially infected with a mixed inoculum of Eimeria labbeana (85 per cent) and E columbarum (15 per cent) and treated orally with 2.5 mg clazuril either on day 1, 2, 3, 4, 5, 6 ... | |
| Efficacy of toltrazuril and clazuril against experimental infections with Eimeria labbeana and E. columbarum in racing pigeons. Avian Dis. 34(1) , 73-9, (1990) The efficacy of toltrazuril in comparison with clazuril on heavy experimental Eimeria labbeana and E. columbarum infections in pigeons was investigated. The minimum required dose of toltrazuril to com... |
Synonyms
| CLAZURIL |
| Clazurilum [Latin] |
| [2-chloro-4-(3,5-dioxo-4,5-dihydro-1,2,4-triazin-2(3h)-yl)phenyl](4-chlorophenyl)acetonitrile |
| Clazurilo [Spanish] |
| Clazuril (USAN/INN) |
| Clazurilo |
| Clazurilum |
