CAS 5696-15-1|Butoxamine hydrochloride
| Common Name | Butoxamine hydrochloride | ||
|---|---|---|---|
| CAS Number | 5696-15-1 | Molecular Weight | 303.82500 |
| Density | / | Boiling Point | 391ºC at 760 mmHg |
| Molecular Formula | C15H26ClNO3 | Melting Point | / |
| MSDS | ChineseUSA | Flash Point | 190.3ºC |
| Symbol | GHS07 | Signal Word | Warning |
Names
| Name | 2-(tert-butylamino)-1-(2,5-dimethoxyphenyl)propan-1-ol,hydrochloride |
|---|---|
| Synonym | More Synonyms |
Butoxamine hydrochloride BiologicalActivity
| Description | Butaxamine (Butoxamin) hydrochloride is a specific β2-adrenergic receptor blocker. Butaxamine hydrochloride inhibits the decreases in urine volume in ethanol-anesthetized, water-diuretic rats[1]. |
|---|---|
| Related Catalog | Research Areas >>EndocrinologySignaling Pathways >>GPCR/G Protein >>Adrenergic Receptor |
| Target | Beta-2 adrenergic receptor |
| In Vivo | Butaxamine hydrochloride（25 μg/kg/min、50 μg/kg/min、100 μg/kg/min，15 分钟；静脉注射）提高了乙醇麻醉、水利尿大鼠的尿量水平[1]。 |
| References | [1]. Shibouta Y, et al. Antidiuresis induced by beta1- and beta2-adrenergic agonists in ethanol-anesthetized rats. Eur J Pharmacol. 1978 Jan 15;47(2):149-57. |
Chemical & Physical Properties
| Boiling Point | 391ºC at 760 mmHg |
|---|---|
| Molecular Formula | C15H26ClNO3 |
| Molecular Weight | 303.82500 |
| Flash Point | 190.3ºC |
| Exact Mass | 303.16000 |
| PSA | 50.72000 |
| LogP | 3.70670 |
| InChIKey | URPAECSKKQLCII-UHFFFAOYSA-N |
| SMILES | COc1ccc(OC)c(C(O)C(C)NC(C)(C)C)c1.Cl |
Safety Information
| Symbol | GHS07 |
|---|---|
| Signal Word | Warning |
| Hazard Statements | H302-H319 |
| Precautionary Statements | P305 + P351 + P338 |
| Personal Protective Equipment | dust mask type N95 (US);Eyeshields;Gloves |
| Hazard Codes | Xn |
| Risk Phrases | 22-36 |
| Safety Phrases | 26 |
| RIDADR | NONH for all modes of transport |
| WGK Germany | 3 |
Articles25
More Articles| Restoration of neutrophil immunocompetence after cardiopulmonary bypass by beta-adrenergic blockers. Surgery 147(4) , 562-74, (2010) To evaluate the possible protective effect of sympatholytic medications with respect to neutrophil function, we evaluated the influence of a nonselective beta-blocker medication on the interaction of ... | |
| Does selective beta-1 blockade provide bone marrow protection after trauma/hemorrhagic shock? Surgery 152(3) , 322-30, (2012) Previously, nonselective beta-blockade (BB) with propranolol demonstrated protection of the bone marrow (BM) after trauma and hemorrhagic shock (HS). Because selective beta-1 blockers are used commonl... | |
| Blocking of beta-2 adrenergic receptors hastens recovery from hypoglycemia-associated social withdrawal. Psychoneuroendocrinology 33(10) , 1411-8, (2008) Hypoglycemia is associated with a variety of adverse behaviors including fatigue, confusion and social withdrawal. While these clinical symptoms are well characterized, the mechanism of their cause is... |
Synonyms
| N-tert.-Butyl-pseudomethoxaminhydrochlorid |
| BUTOXAMINE HYDROCHLORIDE |
| Butoxamine hydrochloride (USAN) |
| BW 64-9 |
| Butoxamine HCl |
| N-tert-Butylmethoxamine hydrochloride |
