CAS 23513-08-8|8-Gingerol

Introduction：Basic information about CAS 23513-08-8|8-Gingerol, including its chemical name, molecular formula, synonyms, physicochemical properties, and safety information, etc.

Table of Contents

1. Names
2. 8-Gingerol BiologicalActivity
3. Chemical & Physical Properties
4. Toxicological Information
CHEMICAL IDENTIFICATION
HEALTH HAZARD DATA
ACUTE TOXICITY DATA
5. Safety Information
6. Articles6
7. Synonyms

Common Name	8-Gingerol
CAS Number	23513-08-8	Molecular Weight	322.439
Density	1.1±0.1 g/cm3	Boiling Point	476.4±35.0 °C at 760 mmHg
Molecular Formula	C₁₉H₃₀O₄	Melting Point	30 - 32 °C
MSDS	ChineseUSA	Flash Point	162.6±19.4 °C
Symbol	GHS07	Signal Word	Warning

Names

Name	[8]-Gingerol
Synonym	More Synonyms

8-Gingerol BiologicalActivity

Description	8-Gingerol, found in the rhizomes of ginger (Z. officinale) with oral bioavailability, activates TRPV1, with an EC50 of 5.0 µM. 8-Gingerol inhibits COX-2, and inhibits the growth of H. pylori in vitro[1][2].
Related Catalog	Signaling Pathways >>Membrane Transporter/Ion Channel >>TRP ChannelResearch Areas >>InfectionResearch Areas >>Inflammation/Immunology
References	[1]. Dedov, V.N., et al. Gingerols: a novel class of vanilloid receptor (VR1) agonists. Br. J. Pharmacol. 137(6), 793-798 (2002). [2]. Chrubasik, S., et al. Zingiberis rhizoma: A comprehensive review on the ginger effect and efficacy profiles. Phytomedicine 12(9), 684-701 (2005).

Description

8-Gingerol, found in the rhizomes of ginger (Z. officinale) with oral bioavailability, activates TRPV1, with an EC50 of 5.0 µM. 8-Gingerol inhibits COX-2, and inhibits the growth of H. pylori in vitro[1][2].

Related Catalog

Signaling Pathways >>Membrane Transporter/Ion Channel >>TRP ChannelResearch Areas >>InfectionResearch Areas >>Inflammation/Immunology

References

[1]. Dedov, V.N., et al. Gingerols: a novel class of vanilloid receptor (VR1) agonists. Br. J. Pharmacol. 137(6), 793-798 (2002).

[2]. Chrubasik, S., et al. Zingiberis rhizoma: A comprehensive review on the ginger effect and efficacy profiles. Phytomedicine 12(9), 684-701 (2005).

Chemical & Physical Properties

Density	1.1±0.1 g/cm3
Boiling Point	476.4±35.0 °C at 760 mmHg
Melting Point	30 - 32 °C
Molecular Formula	C₁₉H₃₀O₄
Molecular Weight	322.439
Flash Point	162.6±19.4 °C
Exact Mass	322.214417
PSA	66.76000
LogP	3.55
Vapour Pressure	0.0±1.3 mmHg at 25°C
Index of Refraction	1.517
InChIKey	BCIWKKMTBRYQJU-INIZCTEOSA-N
SMILES	CCCCCCCC(O)CC(=O)CCc1ccc(O)c(OC)c1
Storage condition	2-8°C
Water Solubility	methanol: soluble1mg/mL, clear, colorless

Toxicological Information

CHEMICAL IDENTIFICATION

RTECS NUMBER :: JR4362000

CHEMICAL NAME :: 3-Dodecanone, 5-hydroxy-1-(4-hydroxy-3-methoxyphenyl)-, (S)-(+)-

CAS REGISTRY NUMBER :: 23513-08-8

LAST UPDATED :: 199503

DATA ITEMS CITED :: 1

MOLECULAR FORMULA :: C19-H30-O4

MOLECULAR WEIGHT :: 322.49

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Intraperitoneal

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: >100 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: ZYZAEU Zhongguo Yaoxue Zazhi. Chinese Pharmacuetical Journal. (China International Book Trading Corp., POB 2820, Beijing, Peop. China) V.24- 1989- Volume(issue)/page/year: 25,231,1990

Safety Information

Symbol	GHS07
Signal Word	Warning
Hazard Statements	H317
Precautionary Statements	P280
Hazard Codes	Xi: Irritant;
Risk Phrases	43
Safety Phrases	36/37
RIDADR	NONH for all modes of transport
WGK Germany	3.0
RTECS	JR4362000
HS Code	29145019

Articles6

Chemical profiling and quantification of Gua-Lou-Gui-Zhi decoction by high performance liquid chromatography/quadrupole-time-of-flight mass spectrometry and ultra-performance liquid chromatography/triple quadrupole mass spectrometry.

J. Chromatogr. B. Analyt. Technol. Biomed. Life Sci. 986-987 , 69-84, (2015)

Gua-Lou-Gui-Zhi decoction (GLGZD) is a classical formula of traditional Chinese medicine, which has been commonly used to treat dysfunction after stroke, epilepsy and spinal cord injury. In this study...

Regioselective glucuronidation of gingerols by human liver microsomes and expressed UDP-glucuronosyltransferase enzymes: reaction kinetics and activity correlation analyses for UGT1A9 and UGT2B7.

J. Pharm. Pharmacol. 67(4) , 583-96, (2015)

To determine the reaction kinetics for regioselective glucuronidation of gingerols (i.e. 6-, 8- and 10-gingerol) by human liver microsomes and expressed UDP-glucuronosyltransferase (UGT) enzymes, and ...

Identification of serotonin 5-HT1A receptor partial agonists in ginger.

Bioorg. Med. Chem. 18 , 3345-51, (2010)

Animal studies suggest that ginger (Zingiber officinale Roscoe) reduces anxiety. In this study, bioactivity-guided fractionation of a ginger extract identified nine compounds that interact with the hu...

Synonyms

8-Gingerol

(S)-5-Hydroxy-1-(4-hydroxy-3-methoxyphenyl)-3-dodecanone

3-Dodecanone, 5-hydroxy-1-(4-hydroxy-3-methoxyphenyl)-, (5S)-

(5s)-5-hydroxy-1-(4-hydroxy-3-methoxyphenyl)dodecan-3-one

(5S)-5-Hydroxy-1-(4-hydroxy-3-methoxyphenyl)-3-dodecanone

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