Introduction：Basic information about CAS 74805-92-8|Methylophiopogonanone A, including its chemical name, molecular formula, synonyms, physicochemical properties, and safety information, etc.
| Common Name | Methylophiopogonanone A |
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| CAS Number | 74805-92-8 | Molecular Weight | 342.343 |
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| Density | 1.4±0.1 g/cm3 | Boiling Point | 580.1±50.0 °C at 760 mmHg |
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| Molecular Formula | C19H18O6 | Melting Point | / |
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| MSDS | / | Flash Point | 212.9±23.6 °C |
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Names
| Name | (3R)-3-(1,3-benzodioxol-5-ylmethyl)-5,7-dihydroxy-6,8-dimethyl-2,3-dihydrochromen-4-one |
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| Synonym | More Synonyms |
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Methylophiopogonanone A BiologicalActivity
| Description | Methylophiopogonanone A, a major homoisoflavonoid in Ophiopogon japonicas, has both anti-oxidative and anti-inflammatory properties[1]. |
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| Related Catalog | Signaling Pathways >>Apoptosis >>ApoptosisResearch Areas >>Inflammation/Immunology |
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| In Vitro | Methylophiopogonanone A (MO-A; 10 μmol/L) significantly decreases apoptosis and cleaved caspase-3 expression, elevated the Bcl-2/Bax ratio and restored NO production. Pretreatment with Methylophiopogonanone A (MO-A) markedly increases the activation of PI3K/Akt/eNOS pathway in H9C2 cells subjected to H/R, and the protective effects of MO-A are abolished in the presence of the PI3K inhibitor wortmannin (100 nmol/L)[1]. |
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| In Vivo | Methylophiopogonanone A (MO-A;10 mg/kg/d, po) for 2 weeks) protects cardiac function following myocardial I/R injury[1]. |
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| References | [1]. He F, et al. Methylophiopogonanone A suppresses ischemia/reperfusion-induced myocardial apoptosis in mice via activating PI3K/Akt/eNOS signaling pathway. Acta Pharmacol Sin. 2016 Jun;37(6):763-71. |
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Chemical & Physical Properties
| Density | 1.4±0.1 g/cm3 |
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| Boiling Point | 580.1±50.0 °C at 760 mmHg |
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| Molecular Formula | C19H18O6 |
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| Molecular Weight | 342.343 |
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| Flash Point | 212.9±23.6 °C |
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| Exact Mass | 342.110352 |
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| PSA | 85.22000 |
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| LogP | 5.16 |
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| Vapour Pressure | 0.0±1.7 mmHg at 25°C |
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| Index of Refraction | 1.654 |
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| InChIKey | BXTNNJIQILYHJB-GFCCVEGCSA-N |
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| SMILES | Cc1c(O)c(C)c2c(c1O)C(=O)C(Cc1ccc3c(c1)OCO3)CO2 |
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Safety Information
Synonyms
| 3-(1,3-Benzodioxol-5-ylmethyl)-5,7-dihydroxy-6,8-dimethyl-2,3-dihydro-4H-chromen-4-one |
| 4H-1-Benzopyran-4-one, 3-(1,3-benzodioxol-5-ylmethyl)-2,3-dihydro-5,7-dihydroxy-6,8-dimethyl- |
| N1002 |
| Methylophiopogonanone A |
