CAS 76862-65-2|α-Conotoxin GI

Introduction：Basic information about CAS 76862-65-2|α-Conotoxin GI, including its chemical name, molecular formula, synonyms, physicochemical properties, and safety information, etc.

Table of Contents

1. Names
2. α-Conotoxin GI BiologicalActivity
3. Chemical & Physical Properties
4. Toxicological Information
CHEMICAL IDENTIFICATION
HEALTH HAZARD DATA
ACUTE TOXICITY DATA
5. Safety Information
6. Synonyms

Common Name	α-Conotoxin GI
CAS Number	76862-65-2	Molecular Weight	1437.61
Density	1.71	Boiling Point	/
Molecular Formula	C₅₅H₈₀N₂₀O₁₈S₄	Melting Point	/
MSDS	/	Flash Point	/

Names

Name	α-CONOTOXIN GI
Synonym	More Synonyms

α-Conotoxin GI BiologicalActivity

Description	α-Conotoxin GI has high affinity for nAChR.α-Conotoxin GI is a short peptide toxin that can be isolated from the venom of Conus geographus.α-Conotoxin GI has the similar activity with neuromuscular blocking agent[1][2][3].
Related Catalog	Signaling Pathways >>Membrane Transporter/Ion Channel >>nAChRSignaling Pathways >>Neuronal Signaling >>nAChRResearch Areas >>Neurological Disease
References	[1]. Groebe DR, et al. Determinants involved in the affinity of alpha-conotoxins GI and SI for the muscle subtype of nicotinic acetylcholine receptors. Biochemistry. 1997 May 27;36(21):6469-74. [2]. Yu S, et al. Sensitive Detection of α-Conotoxin GI in Human Plasma Using a Solid-Phase Extraction Column and LC-MS/MS. Toxins (Basel). 2017 Jul 28;9(8):235. [3]. Blount K, et al. alpha-Conotoxin GI produces tetanic fade at the rat neuromuscular junction. Toxicon. 1992 Aug;30(8):835-42.

Description

α-Conotoxin GI has high affinity for nAChR.α-Conotoxin GI is a short peptide toxin that can be isolated from the venom of Conus geographus.α-Conotoxin GI has the similar activity with neuromuscular blocking agent[1][2][3].

Related Catalog

Signaling Pathways >>Membrane Transporter/Ion Channel >>nAChRSignaling Pathways >>Neuronal Signaling >>nAChRResearch Areas >>Neurological Disease

References

[1]. Groebe DR, et al. Determinants involved in the affinity of alpha-conotoxins GI and SI for the muscle subtype of nicotinic acetylcholine receptors. Biochemistry. 1997 May 27;36(21):6469-74.

[2]. Yu S, et al. Sensitive Detection of α-Conotoxin GI in Human Plasma Using a Solid-Phase Extraction Column and LC-MS/MS. Toxins (Basel). 2017 Jul 28;9(8):235.

[3]. Blount K, et al. alpha-Conotoxin GI produces tetanic fade at the rat neuromuscular junction. Toxicon. 1992 Aug;30(8):835-42.

Chemical & Physical Properties

Density	1.71
Molecular Formula	C₅₅H₈₀N₂₀O₁₈S₄
Molecular Weight	1437.61
Exact Mass	1436.48000
PSA	722.15000
Storage condition	-20°C

Toxicological Information

CHEMICAL IDENTIFICATION

RTECS NUMBER :: GL1500000

CHEMICAL NAME :: Conotoxin GI

CAS REGISTRY NUMBER :: 76862-65-2

LAST UPDATED :: 199506

DATA ITEMS CITED :: 1

MOLECULAR FORMULA :: C55-H80-N20-O18-S4

MOLECULAR WEIGHT :: 1437.79

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Intraperitoneal

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 12 ug/kg

TOXIC EFFECTS :: Peripheral Nerve and Sensation - flaccid paralysis without anesthesia (usually neuromuscular blockage) Lungs, Thorax, or Respiration - other changes

REFERENCE :: ABBIA4 Archives of Biochemistry and Biophysics. (Academic Press, Inc., 1 E. First St., Duluth, MN 55802) V.31- 1951- Volume(issue)/page/year: 190,539,1978

Safety Information

Hazard Codes	Xn
RIDADR	UN 3172
Packaging Group	III
Hazard Class	6.1(b)

Synonyms

GLU-CYS-CYS-ASN-PRO-ALA-CYS-GLY-ARG-HIS-TYR-SER-CYS-NH2

a-Conotoxin GI

CONOTOXIN GI

a-Conotoxin GI,Conus geographus

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