Introduction：Basic information about CAS 106-14-9|12-hydroxyoctadecanoic acid, including its chemical name, molecular formula, synonyms, physicochemical properties, and safety information, etc.
| Common Name | 12-hydroxyoctadecanoic acid |
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| CAS Number | 106-14-9 | Molecular Weight | 300.477 |
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| Density | 0.9±0.1 g/cm3 | Boiling Point | 436.3±18.0 °C at 760 mmHg |
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| Molecular Formula | C18H36O3 | Melting Point | 80-81ºC |
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| MSDS | ChineseUSA | Flash Point | 231.8±17.7 °C |
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Names
| Name | 12-hydroxyoctadecanoic acid |
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| Synonym | More Synonyms |
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12-hydroxyoctadecanoic acid BiologicalActivity
| Description | 12-Hydroxystearic acid is a structurally simple and cost-effective low molecular weight organogelator, and its metal salts and derivatives find roles in many important applications[1][2]. |
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| Related Catalog | Research Areas >>OthersSignaling Pathways >>Others >>Others |
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| In Vitro | 12-Hydroxystearic acid (12HSA) and its derivatives have been studied in great detail due to it is effectiveness as a gelator and utility in lubricants[1]. |
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| References | [1]. Gordon R, et al. Aggregation of 12-Hydroxystearic Acid and Its Lithium Salt in Hexane: Molecular Dynamics Simulations. J Phys Chem B. 2016;120(29):7164-7173. |
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Chemical & Physical Properties
| Density | 0.9±0.1 g/cm3 |
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| Boiling Point | 436.3±18.0 °C at 760 mmHg |
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| Melting Point | 80-81ºC |
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| Molecular Formula | C18H36O3 |
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| Molecular Weight | 300.477 |
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| Flash Point | 231.8±17.7 °C |
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| Exact Mass | 300.266449 |
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| PSA | 57.53000 |
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| LogP | 6.03 |
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| Vapour Pressure | 0.0±2.4 mmHg at 25°C |
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| Index of Refraction | 1.468 |
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| InChIKey | ULQISTXYYBZJSJ-UHFFFAOYSA-N |
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| SMILES | CCCCCCC(O)CCCCCCCCCCC(=O)O |
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| Storage condition | −20°C |
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Toxicological Information
CHEMICAL IDENTIFICATION - RTECS NUMBER :
- WI3850000
- CHEMICAL NAME :
- Stearic acid, 12-hydroxy-
- CAS REGISTRY NUMBER :
- 106-14-9
- BEILSTEIN REFERENCE NO. :
- 1726730
- LAST UPDATED :
- 199701
- DATA ITEMS CITED :
- 5
- MOLECULAR FORMULA :
- C18-H36-O3
- MOLECULAR WEIGHT :
- 300.54
- WISWESSER LINE NOTATION :
- QV10YQ6
HEALTH HAZARD DATAACUTE TOXICITY DATA - TYPE OF TEST :
- TDLo - Lowest published toxic dose
- ROUTE OF EXPOSURE :
- Subcutaneous
- SPECIES OBSERVED :
- Rodent - mouse
- DOSE/DURATION :
- 160 mg/kg/40W-I
- TOXIC EFFECTS :
- Tumorigenic - neoplastic by RTECS criteria Lungs, Thorax, or Respiration - tumors Tumorigenic - tumors at site of application
MUTATION DATA - TYPE OF TEST :
- Mutation in microorganisms
- TEST SYSTEM :
- Bacteria - Escherichia coli
- DOSE/DURATION :
- 700 umol/L
- REFERENCE :
- MUREAV Mutation Research. (Elsevier Science Pub. B.V., POB 211, 1000 AE Amsterdam, Netherlands) V.1- 1964- Volume(issue)/page/year: 122,87,1983 *** NIOSH STANDARDS DEVELOPMENT AND SURVEILLANCE DATA *** NIOSH OCCUPATIONAL EXPOSURE SURVEY DATA : NOHS - National Occupational Hazard Survey (1974) NOHS Hazard Code - M1187 No. of Facilities: 5682 (estimated) No. of Industries: 85 No. of Occupations: 50 No. of Employees: 71848 (estimated) NOES - National Occupational Exposure Survey (1983) NOES Hazard Code - M1187 No. of Facilities: 5607 (estimated) No. of Industries: 44 No. of Occupations: 38 No. of Employees: 52609 (estimated) No. of Female Employees: 4374 (estimated)
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Safety Information
| Personal Protective Equipment | dust mask type N95 (US);Eyeshields;Gloves |
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| Hazard Codes | Xi: Irritant; |
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| Risk Phrases | R36/37/38 |
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| Safety Phrases | S22-S24/25 |
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| RIDADR | NONH for all modes of transport |
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| WGK Germany | 3 |
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| RTECS | WI3850000 |
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| HS Code | 2942000000 |
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Customs
| HS Code | 2918199090 |
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| Summary | 2918199090 other carboxylic acids with alcohol function but without other oxygen function, their anhydrides, halides, peroxides, peroxyacids and their derivatives。Supervision conditions:None。VAT:17.0%。Tax rebate rate:9.0%。MFN tariff:6.5%。General tariff:30.0% |
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Articles6
More Articles
| Novel semisolid SNEDDS based on PEG-30-di-(polyhydroxystearate): Progesterone incorporation and in vitro digestion. Int. J. Pharm. 486 , 77-87, (2015) The aim of this work is to study the digestibility of PEG-30-di-(polyhydroxystearate) (Cithrol(®) DPHS) and its semisolid novel self-nanoemulsifying drug delivery systems (SNEDDS). Furthermore, the SN... | |
| Development of multifunctional lipid nanocapsules for the co-delivery of paclitaxel and CpG-ODN in the treatment of glioblastoma. Int. J. Pharm. 495 , 972-80, (2015) In this work, multifunctional lipid nanocapsules (M-LNC) were designed to combine the activity of the cytotoxic drug paclitaxel (PTX) with the immunostimulant CpG. This nanosystem, consisting of modif... | |
| Core-shell structured gel-nanocarriers for sustained drug release and enhanced antitumor effect. Int. J. Pharm. 484(1-2) , 163-71, (2015) The present paper attempted to develop temperature-sensitive and core-shell structured gel-nanocarriers (gel-NCs) for paclitaxel (PTX) with 12-hydroxystearic acid (12-HSA) as an organic gelator, which... | |
Synonyms
| MFCD00004592 |
| DL-12-hydroxystearic acid |
| Octadecanoic acid, 12-hydroxy- |
| EINECS 203-366-1 |
| UNII:933ANU3H2S |
| 12-Hydroxyoctadecanoic acid |
| DL-12-hydroxy stearic acid |
| 12-Hydroxystearic acid |
