CAS 10140-70-2|Curvularin
| Common Name | Curvularin | ||
|---|---|---|---|
| CAS Number | 10140-70-2 | Molecular Weight | 292.32700 |
| Density | 1.2g/cm3 | Boiling Point | 557ºC at 760mmHg |
| Molecular Formula | C16H20O5 | Melting Point | 205-207 °C |
| MSDS | ChineseUSA | Flash Point | 207.9ºC |
| Symbol | GHS07 | Signal Word | Warning |
Names
| Name | 2H-3-Benzoxacyclododecin-2,10(1H)-dione, 4,5,6,7,8,9-hexahydro-11,13-dihydroxy-4-methyl-, (-) |
|---|---|
| Synonym | More Synonyms |
Curvularin BiologicalActivity
| Description | Curvularin, a fungal metabolite and a potent mycotoxin naturally isolated from Curvularia lunata, inhibits cytokine-induced nitric oxide synthase (iNOS), with an IC50 of 9.5 µM[1][2]. |
|---|---|
| Related Catalog | Research Areas >>OthersSignaling Pathways >>Immunology/Inflammation >>NO Synthase |
| Target | IC50: 9.5 µM (iNOS)[2]. |
| References | [1]. Kumar CG, et al. Metabolite profiling and biological activities of bioactive compounds produced by Chrysosporium lobatum strain BK-3 isolated from Kaziranga National Park, Assam, India. Springerplus. 2013 Dec;2(1):122. [2]. Yao Y, et al. Sporogen, S14-95, and S-curvularin, three inhibitors of human inducible nitric-oxide synthase expression isolated from fungi. Mol Pharmacol. 2003 Feb;63(2):383-91. |
Chemical & Physical Properties
| Density | 1.2g/cm3 |
|---|---|
| Boiling Point | 557ºC at 760mmHg |
| Melting Point | 205-207 °C |
| Molecular Formula | C16H20O5 |
| Molecular Weight | 292.32700 |
| Flash Point | 207.9ºC |
| Exact Mass | 292.13100 |
| PSA | 83.83000 |
| LogP | 2.71880 |
| Vapour Pressure | 5.18E-13mmHg at 25°C |
| Index of Refraction | 1.54 |
| InChIKey | VDUIGYAPSXCJFC-JTQLQIEISA-N |
| SMILES | CC1CCCCCC(=O)c2c(O)cc(O)cc2CC(=O)O1 |
Safety Information
| Symbol | GHS07 |
|---|---|
| Signal Word | Warning |
| Hazard Statements | H302 |
| Hazard Codes | Xn |
| RIDADR | NONH for all modes of transport |
Articles15
More Articles| Sulfur-containing cytotoxic curvularin macrolides from Penicillium sumatrense MA-92, a fungus obtained from the rhizosphere of the mangrove Lumnitzera racemosa. J. Nat. Prod. 76(11) , 2145-9, (2013) Sumalarins A-C (1-3), the new and rare examples of sulfur-containing curvularin derivatives, along with three known analogues (4-6), were isolated and identified from the cytotoxic extract of Penicill... | |
| Metabolite production by differentUlocladiumspecies Int. J. Food Microbiol. 126(1-2) , 172-9, (2008) Ulocladium, which is phylogenetically related to Alternaria, contains species that are food spoilers and plant pathogens, but also species that have potential as enzyme producers and bio-control agent... | |
| [Molecular basis of probes for cytoskeletal proteins]. Tanpakushitsu Kakusan Koso. 38(11) , 1730-41, (1993) |
Synonyms
| curvularin |
