Introduction：Basic information about CAS 102195-79-9|(2S,4S)-1-tert-Butyl 2-methyl 4-hydroxypyrrolidine-1,2-dicarboxylate, including its chemical name, molecular formula, synonyms, physicochemical properties, and safety information, etc.
| Common Name | (2S,4S)-1-tert-Butyl 2-methyl 4-hydroxypyrrolidine-1,2-dicarboxylate |
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| CAS Number | 102195-79-9 | Molecular Weight | 245.272 |
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| Density | 1.2±0.1 g/cm3 | Boiling Point | 335.2±42.0 °C at 760 mmHg |
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| Molecular Formula | C11H19NO5 | Melting Point | 82-86ºC |
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| MSDS | ChineseUSA | Flash Point | 156.6±27.9 °C |
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| Symbol |
GHS07 | Signal Word | Warning |
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Names
| Name | N-Boc-cis-4-hydroxy-L-proline Methyl Ester |
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| Synonym | More Synonyms |
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BiologicalActivity
| Description | N-Boc-cis-4-hydroxy-L-proline methyl ester is a non-cleavable ADC linker used in the synthesis of antibody-drug conjugates (ADCs). N-Boc-cis-4-hydroxy-L-proline methyl ester is also a alkyl chain-based PROTAC linker that can be used in the synthesis of PROTACs[1][2 |
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| Related Catalog | Research Areas >>CancerSignaling Pathways >>Antibody-drug Conjugate >>ADC LinkerSignaling Pathways >>PROTAC >>PROTAC Linker |
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| Target | Non-cleavable |
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| In Vitro | ADCs are comprised of an antibody to which is attached an ADC cytotoxin through an ADC linker[1]. PROTACs contain two different ligands connected by a linker; one is a ligand for an E3 ubiquitin ligase and the other is for the target protein. PROTACs exploit the intracellular ubiquitin-proteasome system to selectively degrade target proteins[2]. |
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| References | [1]. Beck A, et al. Strategies and challenges for the next generation of antibody-drug conjugates. Nat Rev Drug Discov. 2017;16(5):315-337. [2]. Nalawansha DA, et al. PROTACs: An Emerging Therapeutic Modality in Precision Medicine. Cell Chem Biol. 2020;27(8):998-985. |
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Chemical & Physical Properties
| Density | 1.2±0.1 g/cm3 |
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| Boiling Point | 335.2±42.0 °C at 760 mmHg |
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| Melting Point | 82-86ºC |
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| Molecular Formula | C11H19NO5 |
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| Molecular Weight | 245.272 |
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| Flash Point | 156.6±27.9 °C |
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| Exact Mass | 245.126328 |
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| PSA | 76.07000 |
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| LogP | -0.25 |
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| Vapour Pressure | 0.0±1.6 mmHg at 25°C |
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| Index of Refraction | 1.501 |
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| InChIKey | MZMNEDXVUJLQAF-YUMQZZPRSA-N |
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| SMILES | COC(=O)C1CC(O)CN1C(=O)OC(C)(C)C |
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| Storage condition | -15°C |
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Safety Information
| Symbol |
GHS07 |
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| Signal Word | Warning |
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| Hazard Statements | H302-H315-H317-H319-H335 |
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| Precautionary Statements | P261-P280-P305 + P351 + P338 |
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| Personal Protective Equipment | dust mask type N95 (US);Eyeshields;Faceshields;Gloves |
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| Hazard Codes | Xn:Harmful; |
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| Risk Phrases | R22;R36/37/38;R43 |
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| Safety Phrases | S26-S36 |
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| RIDADR | NONH for all modes of transport |
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| WGK Germany | 2 |
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| HS Code | 2933990090 |
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Customs
| HS Code | 2933990090 |
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| Summary | 2933990090. heterocyclic compounds with nitrogen hetero-atom(s) only. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:20.0% |
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Synonyms
| (2S,4S)-4-Hydroxypyrrolidine-1,2-dicarboxylic Acid 1-tert-Butyl 2-Methyl Ester |
| N-(tert-Butoxycarbonyl)-cis-4-hydroxy-L-proline Methyl Ester |
| 1-O-tert-butyl 2-O-methyl (2S,4S)-4-hydroxypyrrolidine-1,2-dicarboxylate |
| N-Boc-cis-4-Hydroxy-L-prolinem ethylester |
| (2S,4S)-1-tert-Butyl 2-methyl 4-hydroxypyrrolidine-1,2-dicarboxylate |
| MFCD00237541 |
| N-Boc-cis-4-hydroxy-L-proline methyl ester |
| 1-tert-Butyl 2-Methyl (2S,4S)-4-Hydroxypyrrolidine-1,2-dicarboxylate |
| Boc-cis-Hyp-OMe |
| cis-Boc-Hyp-OMe |
