Introduction：Basic information about CAS 947303-87-9|PF-429242, including its chemical name, molecular formula, synonyms, physicochemical properties, and safety information, etc.
| Common Name | PF-429242 |
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| CAS Number | 947303-87-9 | Molecular Weight | 409.56 |
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| Density | 1.1±0.1 g/cm3 | Boiling Point | 562.2±50.0 °C at 760 mmHg |
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| Molecular Formula | C25H35N3O2 | Melting Point | / |
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| MSDS | / | Flash Point | 293.8±30.1 °C |
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Names
| Name | (R)-4-((Diethylamino)methyl)-N-(2-methoxyphenethyl)-N-(pyrrolidin-3-yl)benzamide |
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| Synonym | More Synonyms |
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PF-429242 BiologicalActivity
| Description | PF429242 is a reversible and competitive SREBP site 1 protease (S1P) inhibitor with an IC50 of 175 nM[1]. |
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| Related Catalog | Signaling Pathways >>Metabolic Enzyme/Protease >>Fatty Acid Synthase (FAS)Research Areas >>InfectionResearch Areas >>Metabolic Disease |
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| References | [1]. Hawkins JL, et al. Pharmacologic inhibition of site 1 protease activity inhibits sterol regulatory element-binding protein processing and reduces lipogenic enzyme gene expression and lipid synthesis in cultured cells and experimental animals. J Pharmacol Exp Ther. 2008 Sep;326(3):801-8. [2]. Uchida L, et al. Suppressive Effects of the Site 1 Protease (S1P) Inhibitor, PF-429242, on Dengue Virus Propagation. Viruses. 2016 Feb 10;8(2). pii: E46. [3]. Urata S, et al. Antiviral activity of a small-molecule inhibitor of arenavirus glycoprotein processing by the cellular site 1 protease. J Virol. 2011 Jan;85(2):795-803. |
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Chemical & Physical Properties
| Density | 1.1±0.1 g/cm3 |
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| Boiling Point | 562.2±50.0 °C at 760 mmHg |
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| Molecular Formula | C25H35N3O2 |
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| Molecular Weight | 409.56 |
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| Flash Point | 293.8±30.1 °C |
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| Exact Mass | 409.272919 |
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| PSA | 44.81000 |
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| LogP | 2.88 |
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| Vapour Pressure | 0.0±1.5 mmHg at 25°C |
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| Index of Refraction | 1.586 |
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| InChIKey | XKPJTOHUPQWSOJ-HSZRJFAPSA-N |
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| SMILES | CCN(CC)Cc1ccc(C(=O)N(CCc2ccccc2OC)C2CCNC2)cc1 |
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| Storage condition | -20℃ |
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Safety Information
Customs
| HS Code | 2933990090 |
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| Summary | 2933990090. heterocyclic compounds with nitrogen hetero-atom(s) only. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:20.0% |
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Synonyms
| 4-[(diethylamino)methyl]-N-[2-(2-methoxyphenyl)ethyl]-N-[(3R)-pyrrolidin-3-yl]benzamide |
| 4-[(Diethylamino)methyl]-N-[2-(2-methoxyphenyl)ethyl]-N-[(3R)-3-pyrrolidinyl]benzamide |
| Benzamide, 4-[(diethylamino)methyl]-N-[2-(2-methoxyphenyl)ethyl]-N-[(3R)-3-pyrrolidinyl]- |
| 4-(diethylaminomethyl)-N-[2-(2-methoxyphenyl)ethyl]-N-[(3R)-pyrrolidin-3-yl]benzamide |
| PF-429242 |
