CAS 93221-48-8|LEVOBETAXOLOL
Introduction：Basic information about CAS 93221-48-8|LEVOBETAXOLOL, including its chemical name, molecular formula, synonyms, physicochemical properties, and safety information, etc.
| Common Name | LEVOBETAXOLOL | ||
|---|---|---|---|
| CAS Number | 93221-48-8 | Molecular Weight | 307.42800 |
| Density | 1.067g/cm3 | Boiling Point | 448ºC at 760 mmHg |
| Molecular Formula | C18H29NO3 | Melting Point | 71-72ºC |
| MSDS | / | Flash Point | 224.7ºC |
Names
| Name | (2S)-1-[4-[2-(cyclopropylmethoxy)ethyl]phenoxy]-3-(propan-2-ylamino)propan-2-ol |
|---|---|
| Synonym | More Synonyms |
LEVOBETAXOLOL BiologicalActivity
| Description | Levobetaxolol is a potent and high affinity β-adrenergic antagonist with IC50 values of 33.2, 2970, 709 nM for guinea pig atrial β1, tracheal β2 and rat colonic β3 receptors, respectively. Levobetaxolol reduces IOP (intraocular pressure). Levobetaxolol exhibits a micromolar affinity for L-type Ca21-channels. Levobetaxolol decreases the effects of ischaemia/reperfusion injury in rats. Levobetaxolol has the potential for the research of glaucoma[1][2]. |
|---|---|
| Related Catalog | Research Areas >>OthersSignaling Pathways >>GPCR/G Protein >>Adrenergic Receptor |
| Target | β1 adrenoceptor:33.2 nM (IC50) β2 adrenoceptor:2970 nM (IC50) β3 adrenoceptor:709 nM (IC50) |
| In Vitro | Levobetaxolol shows a higher affinity at cloned human β1 and β2 receptor with Ki values of 0.76, 32.6 nM, respectively[1]. Levobetaxolol inhibits functional activities in cells expressing human recombinant β1 and β2 receptors with Kb values of 6, 39 nM, respectively[1]. |
| References | [1]. Sharif NA, et al. Levobetaxolol (Betaxon) and other beta-adrenergic antagonists: preclinical pharmacology, IOP-lowering activity and sites of action in human eyes. J Ocul Pharmacol Ther. 2001 Aug;17(4):305-17. [2]. Osborne NN, et al. Effectiveness of levobetaxolol and timolol at blunting retinal ischaemia is related to their calcium and sodium blocking activities: relevance to glaucoma. Brain Res Bull. 2004 Feb 15;62(6):525-8. |
Chemical & Physical Properties
| Density | 1.067g/cm3 |
|---|---|
| Boiling Point | 448ºC at 760 mmHg |
| Melting Point | 71-72ºC |
| Molecular Formula | C18H29NO3 |
| Molecular Weight | 307.42800 |
| Flash Point | 224.7ºC |
| Exact Mass | 307.21500 |
| PSA | 50.72000 |
| LogP | 2.78430 |
| Index of Refraction | 1.529 |
| InChIKey | NWIUTZDMDHAVTP-KRWDZBQOSA-N |
| SMILES | CC(C)NCC(O)COc1ccc(CCOCC2CC2)cc1 |
Synonyms
| (S)-(-)-Betaxolol |
| Levobetaxolol |
| (S)-(-)-3-<4-<2-(cyclopropylmethoxy)ethyl>phenoxy>-1-(isopropylamino)-2-propanol |
| UNII-75O9XHA4TU |
| (-)-Betaxolol |
| Levobetaxolol [INN] |
| (S)-(-)-3-[4-[2-(cyclopropylmethoxy)]ethyl]phenoxy-1-(N-isopropylamino)-propan-2-ol |
