Introduction：Basic information about CAS 93952-19-3|p,p'-DDE-d8, including its chemical name, molecular formula, synonyms, physicochemical properties, and safety information, etc.
| Common Name | p,p'-DDE-d8 |
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| CAS Number | 93952-19-3 | Molecular Weight | 326.07500 |
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| Density | / | Boiling Point | / |
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| Molecular Formula | C14Cl4D8 | Melting Point | / |
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| MSDS | / | Flash Point | / |
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Names
p,p'-DDE-d8 BiologicalActivity
| Description | p,p'-DDE-d8 is the deuterium labeled p,p'-DDE[1]. p,p'-DDE (4,4'-DDE), a major metabolite of persistent dichlorodiphenyltrichloroethane (DDT), is a potent androgen receptor antagonist, with an IC50 of 5 μM and a Ki of 3.5 μM[2]. |
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| Related Catalog | Research Areas >>EndocrinologySignaling Pathways >>Others >>Androgen Receptor |
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| In Vitro | Stable heavy isotopes of hydrogen, carbon, and other elements have been incorporated into drug molecules, largely as tracers for quantitation during the drug development process. Deuteration has gained attention because of its potential to affect the pharmacokinetic and metabolic profiles of drugs[1]. |
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| References | [1]. Russak EM, et al. Impact of Deuterium Substitution on the Pharmacokinetics of Pharmaceuticals. Ann Pharmacother. 2019 Feb;53(2):211-216. [2]. Kelce WR, et al. Persistent DDT metabolite p,p'-DDE is a potent androgen receptor antagonist. Nature. 1995;375(6532):581-585. |
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Chemical & Physical Properties
| Molecular Formula | C14Cl4D8 |
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| Molecular Weight | 326.07500 |
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| Exact Mass | 323.98800 |
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| LogP | 6.18790 |
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| InChIKey | UCNVFOCBFJOQAL-PGRXLJNUSA-N |
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| SMILES | ClC(Cl)=C(c1ccc(Cl)cc1)c1ccc(Cl)cc1 |
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