CAS 943-17-9|Efortil

Introduction：Basic information about CAS 943-17-9|Efortil, including its chemical name, molecular formula, synonyms, physicochemical properties, and safety information, etc.

Table of Contents

1. Names
2. Efortil BiologicalActivity
3. Chemical & Physical Properties
4. Toxicological Information
CHEMICAL IDENTIFICATION
HEALTH HAZARD DATA
ACUTE TOXICITY DATA
5. Safety Information
6. Customs
7. Articles24
8. Synonyms

Common Name	Efortil
CAS Number	943-17-9	Molecular Weight	217.69
Density	1.127g/cm3	Boiling Point	351.7ºC at 760 mmHg
Molecular Formula	C₁₀H₁₆ClNO₂	Melting Point	122ºC
MSDS	/	Flash Point	155.5ºC
Symbol	GHS06	Signal Word	Danger

Names

Name	3-[2-(ethylamino)-1-hydroxyethyl]phenol,hydrochloride
Synonym	More Synonyms

Efortil BiologicalActivity

Description	Etilefrine hydrochloride is an orally active α adrenergic agonist. Etilefrine hydrochloride is also an AMPK activator. Etilefrine hydrochloride can be used for the research of postural hypotension[1][2][3][4].
Related Catalog	Signaling Pathways >>Epigenetics >>AMPKResearch Areas >>Cardiovascular DiseaseSignaling Pathways >>GPCR/G Protein >>Adrenergic ReceptorSignaling Pathways >>PI3K/Akt/mTOR >>AMPK
References	[1]. Sylvain Tollis, et al. Chemical Interrogation of Nuclear Size Identifies Compounds with Cancer Cell Line-Specific Effects on Migration and Invasion. ACS Chem Biol. 2022 Feb 24. [2]. Chi Xu, et al. Accurate Drug Repositioning through Non-tissue-Specific Core Signatures from Cancer Transcriptomes. Cell Rep. 2018 Oct 9;25(2):523-535.e5. [3]. R Yamazaki, et al. Effects of dihydroergotamine and Etilefrine on experimentally-induced postural hypotension in dogs. J Pharmacobiodyn. 1990 Sep;13(9):519-24. [4]. Bouaggad A, et al. The effect of oral etilefrine premedication on the incidence of hypotension during spinal anaesthesia. Eur J Anaesthesiol. 2000 Mar;17(3):177-81.

Description

Etilefrine hydrochloride is an orally active α adrenergic agonist. Etilefrine hydrochloride is also an AMPK activator. Etilefrine hydrochloride can be used for the research of postural hypotension[1][2][3][4].

Related Catalog

Signaling Pathways >>Epigenetics >>AMPKResearch Areas >>Cardiovascular DiseaseSignaling Pathways >>GPCR/G Protein >>Adrenergic ReceptorSignaling Pathways >>PI3K/Akt/mTOR >>AMPK

References

[1]. Sylvain Tollis, et al. Chemical Interrogation of Nuclear Size Identifies Compounds with Cancer Cell Line-Specific Effects on Migration and Invasion. ACS Chem Biol. 2022 Feb 24.

[2]. Chi Xu, et al. Accurate Drug Repositioning through Non-tissue-Specific Core Signatures from Cancer Transcriptomes. Cell Rep. 2018 Oct 9;25(2):523-535.e5.

[3]. R Yamazaki, et al. Effects of dihydroergotamine and Etilefrine on experimentally-induced postural hypotension in dogs. J Pharmacobiodyn. 1990 Sep;13(9):519-24.

[4]. Bouaggad A, et al. The effect of oral etilefrine premedication on the incidence of hypotension during spinal anaesthesia. Eur J Anaesthesiol. 2000 Mar;17(3):177-81.

Chemical & Physical Properties

Density	1.127g/cm3
Boiling Point	351.7ºC at 760 mmHg
Melting Point	122ºC
Molecular Formula	C₁₀H₁₆ClNO₂
Molecular Weight	217.69
Flash Point	155.5ºC
Exact Mass	217.086960
PSA	52.49000
LogP	2.22800
InChIKey	KTNROWWHOBZQGK-UHFFFAOYSA-N
SMILES	CCNCC(O)c1cccc(O)c1.Cl
Water Solubility	Freely soluble in water, soluble in ethanol (96 per cent), practically insoluble in methylene chloride

Toxicological Information

CHEMICAL IDENTIFICATION

RTECS NUMBER :: DO5618000

CHEMICAL NAME :: Benzyl alcohol, alpha-((ethylamino)methyl)-m-hydroxy-, hydrochloride

CAS REGISTRY NUMBER :: 943-17-9

LAST UPDATED :: 199806

DATA ITEMS CITED :: 6

MOLECULAR FORMULA :: C10-H15-N-O2.Cl-H

MOLECULAR WEIGHT :: 217.72

WISWESSER LINE NOTATION :: QR CYQ1M2 &GH

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

TYPE OF TEST :: LDLo - Lowest published lethal dose

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: 187 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: DRFUD4 Drugs of the Future. (J.R. Prous, S.A., Apartado de Correos 540, 08080 Barcelona, Spain) V.1- 1975/76- Volume(issue)/page/year: 4,413,1979

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Subcutaneous

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: >420 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: NIIRDN Drugs in Japan (Ethical Drugs). (Yakugyo Jiho Co., Ltd., Tokyo, Japan) Volume(issue)/page/year: -,187,1990

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Intravenous

SPECIES OBSERVED :: Rodent - rat

DOSE/DURATION :: 3 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: NIIRDN Drugs in Japan (Ethical Drugs). (Yakugyo Jiho Co., Ltd., Tokyo, Japan) Volume(issue)/page/year: -,225,1995

TYPE OF TEST :: LDLo - Lowest published lethal dose

ROUTE OF EXPOSURE :: Oral

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 345 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: DRFUD4 Drugs of the Future. (J.R. Prous, S.A., Apartado de Correos 540, 08080 Barcelona, Spain) V.1- 1975/76- Volume(issue)/page/year: 4,413,1979

TYPE OF TEST :: LD50 - Lethal dose, 50 percent kill

ROUTE OF EXPOSURE :: Subcutaneous

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 860 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: NIIRDN Drugs in Japan (Ethical Drugs). (Yakugyo Jiho Co., Ltd., Tokyo, Japan) Volume(issue)/page/year: 6,115,1982

TYPE OF TEST :: LDLo - Lowest published lethal dose

ROUTE OF EXPOSURE :: Intravenous

SPECIES OBSERVED :: Rodent - mouse

DOSE/DURATION :: 11 mg/kg

TOXIC EFFECTS :: Details of toxic effects not reported other than lethal dose value

REFERENCE :: DRFUD4 Drugs of the Future. (J.R. Prous, S.A., Apartado de Correos 540, 08080 Barcelona, Spain) V.1- 1975/76- Volume(issue)/page/year: 4,413,1979

Safety Information

Symbol	GHS06
Signal Word	Danger
Hazard Statements	H301-H319
Precautionary Statements	Missing Phrase - N15.00950417-P305 + P351 + P338
RIDADR	UN 2811 6.1 / PGIII
RTECS	DO5618000
HS Code	2922509090

Customs

HS Code	2922509090
Summary	2922509090. other amino-alcohol-phenols, amino-acid-phenols and other amino-compounds with oxygen function. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:30.0%

Articles24

Indications, surgical technique, and long-term experience with laparoscopic closure of the nephrosplenic space in standing horses.

Vet. Surg. 34(6) , 637-41, (2005)

To describe surgical technique and outcome after laparoscopic closure of the nephrosplenic space for treatment of recurrent left dorsal displacement of the left colon (LDDLC) in standing horses.Retros...

[A complicated course after esophagogastrectomy].

J. Chir. (Paris.) 144(3) , 241-5, (2007)

Priapism in a patient with unstable hemoglobin: hemoglobin Köln.

Am. J. Hematol. 74(1) , 73-4, (2003)

We report a case of severe priapism occurring in a patient with unstable hemoglobin, hemoglobin Köln, and underline several factors that may have contributed to this complication: abnormal plasticity ...

Synonyms

etilefrine hydrochloride

Effortil

α-[(Ethylamino)methyl]-3-hydroxybenzenemethanol hydrochloride

N-Ethyl-1-(m-hydroxyphenyl)-2-aminoethanol hydrochloride

3-[2-(ethylamino)-1-hydroxyethyl]phenol hydrochloride

Thomasin

Benzenemethanol, α-[(ethylamino)methyl]-3-hydroxy-, hydrochloride (1:1)

Effortil*HCl

EINECS 213-398-8

Etilefrin-HCl

3-[2-(Ethylamino)-1-hydroxyethyl]phenol hydrochloride (1:1)

Etilefrin dl-form hydrochloride

Cardanat

Etilefrine HCl

Effontil

Efortil

Circupon

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