Introduction：Basic information about CAS 746667-48-1|BIO-013077-01, including its chemical name, molecular formula, synonyms, physicochemical properties, and safety information, etc.
| Common Name | BIO-013077-01 |
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| CAS Number | 746667-48-1 | Molecular Weight | 287.31900 |
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| Density | / | Boiling Point | / |
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| Molecular Formula | C17H13N5 | Melting Point | / |
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| MSDS | / | Flash Point | / |
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Names
| Name | 6-[5-(6-methylpyridin-2-yl)-1H-pyrazol-4-yl]quinoxaline |
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| Synonym | More Synonyms |
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BIO-013077-01 BiologicalActivity
| Description | BIO-013077-01 is a pyrazole TGF-β inhibitor[1]. |
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| Related Catalog | Research Areas >>Cancer |
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| In Vitro | A wide range of cellular functions such as cell proliferation, differentiation, adhesion, migration, and apoptosis are regulated by TGF-β superfamily members. The TGF-βs include the three major TGF-β isoforms, TGF-β1, TGF-β2, and TGF-β3 which are expressed in mammals. TGF-β transduces signals through a complex of two related but structurally and functionally distinct serine/threonine kinase receptors, termed type 1 and type II. Deregulation of TGF-β signaling has been also implicated in various human diseases including cancer, pancreatic diseases, and hematological malignancies[1]. |
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| In Vivo | TGF-β Inhibitor |
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| References | [1]. Jin CH, et al. Synthesis and biological evaluation of 1-substituted-3(5)-(6-methylpyridin-2-yl)-4-(quinoxalin-6-yl)pyrazoles as transforming growth factor-β type 1 receptor kinase inhibitors. Eur J Med Chem. 2011 Sep;46(9):3917-25. |
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Chemical & Physical Properties
| Molecular Formula | C17H13N5 |
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| Molecular Weight | 287.31900 |
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| Exact Mass | 287.11700 |
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| PSA | 67.35000 |
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| LogP | 3.39030 |
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| InChIKey | VXJLYXCHOKEODY-UHFFFAOYSA-N |
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| SMILES | Cc1cccc(-c2[nH]ncc2-c2ccc3nccnc3c2)n1 |
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Safety Information
Customs
| HS Code | 2933990090 |
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| Summary | 2933990090. heterocyclic compounds with nitrogen hetero-atom(s) only. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:20.0% |
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Synonyms
| 6-(3-(6-Methylpyridin-2-yl)-1H-pyrazol-4-yl)quinoxaline |
| Quinoxaline |
