Introduction：Basic information about CAS 146510-36-3|Olanexidine, including its chemical name, molecular formula, synonyms, physicochemical properties, and safety information, etc.
| Common Name | Olanexidine |
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| CAS Number | 146510-36-3 | Molecular Weight | 372.33600 |
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| Density | 1.22g/cm3 | Boiling Point | 503.3ºC at 760 mmHg |
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| Molecular Formula | C17H27Cl2N5 | Melting Point | / |
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| MSDS | / | Flash Point | 258.2ºC |
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Names
| Name | 1-carbamimidoyl-2-[(3,4-dichlorophenyl)methyl]-1-octylguanidine |
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| Synonym | More Synonyms |
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Olanexidine BiologicalActivity
| Description | Olanexidine is an antibacterial agent. Olanexidine is active against a wide range of bacteria, imcluding both Gram-positive and Gram-negative bacteria Olanexidine is also an antiseptic. Olanexidine can be used in the research of infection and inflammation[1][2][3]. |
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| Related Catalog | Research Areas >>InfectionResearch Areas >>Inflammation/ImmunologySignaling Pathways >>Anti-infection >>Bacterial |
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| In Vitro | Olanexidine (50 μM, 48 h) exhibits broad-spectrum bactericidal activity against Gram-positive cocci and Gram-negative bacteria[1]. Olanexidine (50 μg/mL, 24 h) inhibits chronic inflammatory reactions in oral mucosal cells[2]. Olanexidine (Olanexidine gluconate, 0-15000 μg/mL) inhibits the binding ability of virus-like particles to the binding receptor of human norovirus and increases the aggregation of virus-like particles[3]. Cell Viability Assay[1] Cell Line: Gram-positive cocci, Enterococcus spp., Gram-positive bacilli, Gram-negative strains Concentration: 0-1 mg/mL approximately Incubation Time: 30 s Result: Inhibited bacterial activity with MIC values ranging from 6.8 to 1740 μg/mL approximately. |
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| In Vivo | Olanexidine (1 -2% in saline, applied to the skin) is active against transient or resident bacterial flora on the skin of male cynomolgus monkeys[4]. Animal Model: Male cynomolgus monkeys[4] Dosage: 1 %, 1.5%, 2% in saline Administration: Applied to the skin Result: Showed the fast-acting and long-lasting bactericidal effects at 1.5% concentration. |
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Chemical & Physical Properties
| Density | 1.22g/cm3 |
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| Boiling Point | 503.3ºC at 760 mmHg |
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| Molecular Formula | C17H27Cl2N5 |
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| Molecular Weight | 372.33600 |
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| Flash Point | 258.2ºC |
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| Exact Mass | 371.16400 |
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| PSA | 83.79000 |
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| LogP | 5.86440 |
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| Vapour Pressure | 2.96E-10mmHg at 25°C |
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| Index of Refraction | 1.576 |
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| InChIKey | ZZQMUJGZCZTLQD-UHFFFAOYSA-N |
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| SMILES | CCCCCCCCN=C(N)NC(N)=NCc1ccc(Cl)c(Cl)c1 |
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Synonyms
| Olanexidine |
| N1-(3,4-Dichlorobenzyl)-N5-octylbiguanide |
| Imidodicarbonimidicdiamide,N-[(3,4-dichlorophenyl)methyl]-N'-octyl |
