Introduction：Basic information about CAS 15503-87-4|(15E)-12,18-Dihydroxysenecionan-11,16-dione, including its chemical name, molecular formula, synonyms, physicochemical properties, and safety information, etc.
| Common Name | (15E)-12,18-Dihydroxysenecionan-11,16-dione |
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| CAS Number | 15503-87-4 | Molecular Weight | 351.394 |
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| Density | 1.3±0.1 g/cm3 | Boiling Point | 583.2±50.0 °C at 760 mmHg |
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| Molecular Formula | C18H25NO6 | Melting Point | / |
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| MSDS | / | Flash Point | 306.5±30.1 °C |
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Names
| Name | Usaramine |
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| Synonym | More Synonyms |
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BiologicalActivity
| Description | Usaramine is a pyrrolizidine alkaloid isolated from seeds of Crolatalaria pallida. Usaramine demonstrates a highlighted antibiofilm activity against Staphylococcus epidermidis by reducing more than 50% of biofilm formation without killing the bacteria[1]. |
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| Related Catalog | Research Areas >>InfectionSignaling Pathways >>Anti-infection >>Bacterial |
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| References | [1]. da Silva Negreiros Neto T, et al. Activity of pyrrolizidine alkaloids against biofilm formation and Trichomonas vaginalis. Biomed Pharmacother. 2016 Oct;83:323-329. |
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Chemical & Physical Properties
| Density | 1.3±0.1 g/cm3 |
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| Boiling Point | 583.2±50.0 °C at 760 mmHg |
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| Molecular Formula | C18H25NO6 |
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| Molecular Weight | 351.394 |
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| Flash Point | 306.5±30.1 °C |
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| Exact Mass | 351.168182 |
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| PSA | 96.30000 |
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| LogP | -0.14 |
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| Vapour Pressure | 0.0±3.7 mmHg at 25°C |
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| Index of Refraction | 1.590 |
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| InChIKey | BCJMNZRQJAVDLD-FXGRWVCYSA-N |
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| SMILES | CC=C1CC(C)C(O)(CO)C(=O)OCC2=CCN3CCC(OC1=O)C23 |
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Toxicological Information
CHEMICAL IDENTIFICATION - RTECS NUMBER :
- VT5707200
- CHEMICAL NAME :
- Senecionan-11,16-dione, 12,18-dihydroxy-, (15E)-
- CAS REGISTRY NUMBER :
- 15503-87-4
- LAST UPDATED :
- 199012
- DATA ITEMS CITED :
- 2
- MOLECULAR FORMULA :
- C18-H25-N-O6
- MOLECULAR WEIGHT :
- 351.44
HEALTH HAZARD DATAACUTE TOXICITY DATA - TYPE OF TEST :
- LDLo - Lowest published lethal dose
- ROUTE OF EXPOSURE :
- Intraperitoneal
- SPECIES OBSERVED :
- Rodent - rat
- DOSE/DURATION :
- 35 mg/kg
- TOXIC EFFECTS :
- Liver - other changes
- REFERENCE :
- CBINA8 Chemico-Biological Interactions. (Elsevier Scientific Pub. Ireland Ltd., POB 85, Limerick, Ireland) V.1- 1969- Volume(issue)/page/year: 12,299,1976
- TYPE OF TEST :
- LD50 - Lethal dose, 50 percent kill
- ROUTE OF EXPOSURE :
- Intraperitoneal
- SPECIES OBSERVED :
- Rodent - mouse
- DOSE/DURATION :
- 300 mg/kg
- TOXIC EFFECTS :
- Details of toxic effects not reported other than lethal dose value
- REFERENCE :
- IJEBA6 Indian Journal of Experimental Biology. (Publications & Information Directorate, CSIR, Hillside Rd., New Delhi 110 012, India) V.1- 1963- Volume(issue)/page/year: 7,144,1969
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Synonyms
| trans-Retrorsin |
| C18H25NO6 |
| (15E)-12,18-dihydroxy-senecionane-11,16-dione |
| [1,6]Dioxacyclododecino[2,3,4-gh]pyrrolizine-2,7-dione, 3-ethylidene-3,4,5,6,9,11,13,14,14a,14b-decahydro-6-hydroxy-6-(hydroxymethyl)-5-methyl-, (3E,5R,6S,14aR,14bR)- |
| Senecionan-11,16-dione,12,18-dihydroxy-,(15E) |
| trans-Retrorsine |
| (15E)-Retrorsine |
| (15E)-12,18-Dihydroxysenecionan-11,16-dione |
| Mucronatine |
| Usaramin |
| (+)-Ursamine |
| Mucronatine (7CI) |
