Introduction：Basic information about CAS 18842-98-3|Paederosidic acid, including its chemical name, molecular formula, synonyms, physicochemical properties, and safety information, etc.
| Common Name | Paederosidic acid |
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| CAS Number | 18842-98-3 | Molecular Weight | 464.441 |
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| Density | 1.7±0.1 g/cm3 | Boiling Point | 748.1±70.0 °C at 760 mmHg |
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| Molecular Formula | C18H24O12S | Melting Point | / |
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| MSDS | / | Flash Point | 406.2±35.7 °C |
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Names
| Name | (1S,4aS,5S,7aS)-1-(β-D-Glucopyranosyloxy)-5-hydroxy-7-({[(methyls ulfanyl)carbonyl]oxy}methyl)-1,4a,5,7a-tetrahydrocyclopenta[c]pyr an-4-carboxylic acid |
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| Synonym | More Synonyms |
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Paederosidic acid BiologicalActivity
| Description | Paederosidic acid is isolated from P. scandens with anticancer and anti‐inflammation activities. Paederosidic acid inhibits lung caner cells via inducing mitochondria-mediated apoptosis[1]. |
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| Related Catalog | Signaling Pathways >>Apoptosis >>ApoptosisResearch Areas >>Cancer |
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| Target | IC50: apoptosis[1] |
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| In Vitro | Paederosidic acid (40 μg/ml; 24 hours and 48 hours) has no significant effect on BSAS-2B cells, it exhibits obvious effects on NCI-H1650, HCC827, A549 cells with IC50 values of 40.68, 42.58, and 36.48 μg/ml, respectively[1]. Paederosidic acid induces mitochondria-mediated apoptosis via up-regulation of caspase-3, caspase-8, caspase-9, Bid, Bax, down-regulation of Bcl-2 and stimulating the release of Cyto-C from mitochondria in lung cancer cells[1]. . |
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| References | [1]. Yu P, et al. Antitumor activity of paederosidic acid in human non-small cell lung cancer cells via inducing mitochondria-mediated apoptosis.Chem Biol Interact. 2017 May 1;269:33-40. [2]. Chen YF, et al. Possible mechanism involved in the antinociceptive activity of dimer of paederosidic acid and paederosidic acid methyl ester in mice.CNS Neurosci Ther. 2014 Feb;20(2):188-90. |
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Chemical & Physical Properties
| Density | 1.7±0.1 g/cm3 |
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| Boiling Point | 748.1±70.0 °C at 760 mmHg |
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| Molecular Formula | C18H24O12S |
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| Molecular Weight | 464.441 |
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| Flash Point | 406.2±35.7 °C |
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| Exact Mass | 464.098846 |
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| PSA | 217.74000 |
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| LogP | -1.48 |
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| Vapour Pressure | 0.0±5.6 mmHg at 25°C |
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| Index of Refraction | 1.666 |
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| InChIKey | ICTKKPLVSHVNDV-FCVLBCLDSA-N |
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| SMILES | CSC(=O)OCC1=CC(O)C2C(C(=O)O)=COC(OC3OC(CO)C(O)C(O)C3O)C12 |
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Synonyms
| paederosidic acid |
| (1S,4aS,5S,7aS)-1-(β-D-Glucopyranosyloxy)-5-hydroxy-7-({[(methylsulfanyl)carbonyl]oxy}methyl)-1,4a,5,7a-tetrahydrocyclopenta[c]pyran-4-carboxylic acid |
| Cyclopenta[c]pyran-4-carboxylic acid, 1-(β-D-glucopyranosyloxy)-1,4a,5,7a-tetrahydro-5-hydroxy-7-[[[(methylthio)carbonyl]oxy]methyl]-, (1S,4aS,5S,7aS)- |
