Introduction：Basic information about CAS 1011301-27-1|Tenovin-3, including its chemical name, molecular formula, synonyms, physicochemical properties, and safety information, etc.
| Common Name | Tenovin-3 |
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| CAS Number | 1011301-27-1 | Molecular Weight | 327.444 |
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| Density | 1.2±0.1 g/cm3 | Boiling Point | / |
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| Molecular Formula | C18H21N3OS | Melting Point | / |
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| MSDS | / | Flash Point | / |
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Names
| Name | N-[(4-aminophenyl)carbamothioyl]-4-tert-butylbenzamide |
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| Synonym | More Synonyms |
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Tenovin-3 BiologicalActivity
| Description | Tenovin-3 is able to increase p53 levels, determined in MCF-7 cells treated for 6 hr at 10 μM.Target: p53in vitro: Tenovins inhibit the activities of human SirT1 and SirT2, two members of the NAD+-dependent class III histone deacetylases that also belong to the sirtuin family.[1] |
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| Related Catalog | Signaling Pathways >>Apoptosis >>MDM-2/p53Research Areas >>Cancer |
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| References | [1]. Lain S, et al. Discovery, in vivo activity, and mechanism of action of a small-molecule p53 activator. Cancer Cell. 2008 May;13(5):454-63. |
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Chemical & Physical Properties
| Density | 1.2±0.1 g/cm3 |
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| Molecular Formula | C18H21N3OS |
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| Molecular Weight | 327.444 |
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| Exact Mass | 327.140533 |
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| PSA | 109.77000 |
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| LogP | 2.82 |
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| Appearance of Characters | yellow solid |
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| Index of Refraction | 1.662 |
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| InChIKey | NLAXTZPUTNGRDU-UHFFFAOYSA-N |
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| SMILES | CC(C)(C)c1ccc(C(=O)NC(=S)Nc2ccc(N)cc2)cc1 |
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| Storage condition | -20℃ |
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Synonyms
| N-[(4-Aminophenyl)carbamothioyl]-4-(2-methyl-2-propanyl)benzamide |
| QC-514 |
| 1-(4-amino-phenyl)-3-(4-tert-butyl-benzoyl)-thiourea |
| N-[(4-aminophenyl)-carbamothioyl]-4-tert-butyl-benzamide |
| Benzamide, N-[[(4-aminophenyl)amino]thioxomethyl]-4-(1,1-dimethylethyl)- |
| Tenovin-3 |
