CAS 1782-65-6|(-)-Hardwickic acid

Introduction：Basic information about CAS 1782-65-6|(-)-Hardwickic acid, including its chemical name, molecular formula, synonyms, physicochemical properties, and safety information, etc.

Table of Contents

1. Names
2. (-)-Hardwickic acid BiologicalActivity
3. Chemical & Physical Properties
4. Safety Information
5. Synonyms

Common Name	(-)-Hardwickic acid
CAS Number	1782-65-6	Molecular Weight	316.435
Density	1.1±0.1 g/cm3	Boiling Point	427.2±18.0 °C at 760 mmHg
Molecular Formula	C₂₀H₂₈O₃	Melting Point	/
MSDS	/	Flash Point	212.2±21.2 °C

Names

Name	(4aR,5R,6R,8aR)-5-[2-(furan-3-yl)ethyl]-5,6,8a-trimethyl-3,4,4a,6,7,8-hexahydronaphthalene-1-carboxylic acid
Synonym	More Synonyms

(-)-Hardwickic acid BiologicalActivity

Description	Hardwickiic acid ((-)-Hardwikiic acid) is an antinociceptive compound that blocks Tetrodotoxin-sensitive voltage-dependent sodium channels. Hardwickiic acid shows insecticidal activity[1][2].
Related Catalog	Signaling Pathways >>Membrane Transporter/Ion Channel >>Sodium ChannelResearch Areas >>InfectionResearch Areas >>Neurological Disease
References	[1]. Cai S, et al. (-)-Hardwickiic Acid and Hautriwaic Acid Induce Antinociception via Blockade of Tetrodotoxin-Sensitive Voltage-Dependent Sodium Channels. ACS Chem Neurosci. 2019 Mar 20;10(3):1716-1728. [2]. Bandara BM, et al. Isolation and Insecticidal Activity of (-)-Hardwickiic Acid from Croton aromaticus. Planta Med. 1987 Dec;53(6):575.

Description

Hardwickiic acid ((-)-Hardwikiic acid) is an antinociceptive compound that blocks Tetrodotoxin-sensitive voltage-dependent sodium channels. Hardwickiic acid shows insecticidal activity[1][2].

Related Catalog

Signaling Pathways >>Membrane Transporter/Ion Channel >>Sodium ChannelResearch Areas >>InfectionResearch Areas >>Neurological Disease

References

[1]. Cai S, et al. (-)-Hardwickiic Acid and Hautriwaic Acid Induce Antinociception via Blockade of Tetrodotoxin-Sensitive Voltage-Dependent Sodium Channels. ACS Chem Neurosci. 2019 Mar 20;10(3):1716-1728.

[2]. Bandara BM, et al. Isolation and Insecticidal Activity of (-)-Hardwickiic Acid from Croton aromaticus. Planta Med. 1987 Dec;53(6):575.

Chemical & Physical Properties

Density	1.1±0.1 g/cm3
Boiling Point	427.2±18.0 °C at 760 mmHg
Molecular Formula	C₂₀H₂₈O₃
Molecular Weight	316.435
Flash Point	212.2±21.2 °C
Exact Mass	316.203857
PSA	50.44000
LogP	6.56
Vapour Pressure	0.0±1.1 mmHg at 25°C
Index of Refraction	1.519
InChIKey	HHWOKJDCJVESIF-UHFFFAOYSA-N
SMILES	CC1CCC2(C)C(C(=O)O)=CCCC2C1(C)CCc1ccoc1

Safety Information

Hazard Codes	Xi

Synonyms

1-Naphthalenecarboxylic acid, 5-[2-(3-furanyl)ethyl]-3,4,4a,5,6,7,8,8a-octahydro-5,6,8a-trimethyl-, (4aR,5S,6R,8aR)-

(-)-Hardwickiic acid

(4aR,5S,6R,8aR)-5-[2-(3-Furyl)ethyl]-5,6,8a-trimethyl-3,4,4a,5,6,7,8,8a-octahydro-1-naphthalenecarboxylic acid

(-)-Hardwickic acid

Recommended......