CAS 94944-70-4|2-ATHBI
| Common Name | 2-ATHBI | ||
|---|---|---|---|
| CAS Number | 94944-70-4 | Molecular Weight | 230.218 |
| Density | 1.5±0.1 g/cm3 | Boiling Point | 613.5±65.0 °C at 760 mmHg |
| Molecular Formula | C9H14N2O5 | Melting Point | / |
| MSDS | ChineseUSA | Flash Point | 324.8±34.3 °C |
| Symbol | GHS07 | Signal Word | Warning |
Names
| Name | 1-[5-[(1R,2S,3R)-1,2,3,4-tetrahydroxybutyl]-1H-imidazol-2-yl]ethanone |
|---|---|
| Synonym | More Synonyms |
2-ATHBI BiologicalActivity
| Description | 2-Acetyl-5-tetrahydroxybutyl imidazole is a potent sphingosine-1-phosphate (S1P) lyase inhibitor in vivo. |
|---|---|
| Related Catalog | Signaling Pathways >>Others >>OthersResearch Areas >>Inflammation/Immunology |
| References | [1]. Inhibition of Sphingosine-1-Phosphate Lyase for the Treatment of Autoimmune Disorders. Med. Chem., 2009, 52 (13), pp 3941-3953 [2]. Schwab SR, et al. Lymphocyte sequestration through S1P lyase inhibition and disruption of S1P gradients. Science. 2005 Sep 9;309(5741):1735-9. |
Chemical & Physical Properties
| Density | 1.5±0.1 g/cm3 |
|---|---|
| Boiling Point | 613.5±65.0 °C at 760 mmHg |
| Molecular Formula | C9H14N2O5 |
| Molecular Weight | 230.218 |
| Flash Point | 324.8±34.3 °C |
| Exact Mass | 230.090271 |
| PSA | 126.67000 |
| LogP | -3.67 |
| Vapour Pressure | 0.0±1.9 mmHg at 25°C |
| Index of Refraction | 1.635 |
| InChIKey | CQSIXFHVGKMLGQ-BWZBUEFSSA-N |
| SMILES | CC(=O)c1ncc(C(O)C(O)C(O)CO)[nH]1 |
Safety Information
| Symbol | GHS07 |
|---|---|
| Signal Word | Warning |
| Hazard Statements | H302 |
| RIDADR | NONH for all modes of transport |
| HS Code | 2933290090 |
Customs
| HS Code | 2933290090 |
|---|---|
| Summary | 2933290090. other compounds containing an unfused imidazole ring (whether or not hydrogenated) in the structure. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:20.0% |
Articles29
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| Effect of oral and parenteral administration of B6 vitamers on the lymphopenia produced by feeding ammonia caramel or 2-acetyl-4(5)-(1,2,3,4-tetrahydroxy)butylimidazole to rats. Food Chem. Toxicol. 27(10) , 627-30, (1989) The ability of B6 vitamers to prevent the lymphopenic effects of ammonia caramel fed to rats has been evaluated. Diets containing 10 ppm pyridoxine or pyridoxal prevented the lymphopenia produced in r... |
Synonyms
| 2-Acetyl-4-tetrahydroxybutylimidazole |
| 1-{5-[(1R,2S,3R)-1,2,3,4-Tetrahydroxybutyl]-1H-imidazol-2-yl}ethanone |
| C9H14N2O5 |
| Ethanone, 1-[5-[(1R,2S,3R)-1,2,3,4-tetrahydroxybutyl]-1H-imidazol-2-yl]- |
| 2-Athbi |
