CAS 501948-05-6|Rosabulin

Introduction：Basic information about CAS 501948-05-6|Rosabulin, including its chemical name, molecular formula, synonyms, physicochemical properties, and safety information, etc.
Common NameRosabulin
CAS Number501948-05-6Molecular Weight400.45300
Density1.34Boiling Point/
Molecular FormulaC22H16N4O2SMelting Point233ºC
MSDS/Flash Point/

Names

Name2-[3-[(4-cyanophenyl)methyl]indolizin-1-yl]-N-(3-methyl-1,2-thiazol-5-yl)-2-oxoacetamide
SynonymMore Synonyms

Rosabulin BiologicalActivity

DescriptionRosabulin is a potent microtubule inhibitor, with anti-cancer activities.
Related CatalogSignaling Pathways >>Cell Cycle/DNA Damage >>Microtubule/TubulinSignaling Pathways >>Cytoskeleton >>Microtubule/TubulinResearch Areas >>Cancer
In VitroRosabulin demonstrates substantial anti-proliferative activity against a wide range of cancer cell linesin vitro, with IC50 values extending down into the nanomolar range. Rosabulin is inhibition of microtubule assembly and subsequent arrest of the cell cycle. Rosabulin is active against several tumor cell lines that express moderate to high levels of P-glycoprotein (Pgp), including lines insensitive to Taxol, Vincristine, and Adriamycin in which Pgp activity is a major contributor to the MDR phenotype[1].
In VivoRosabulin has shown in vivo activity in several murine tumors as well as human tumor xenograft models, including drug resistant tumors[1].
References

[1]. Keizo Koya, et al. STA-5312, a novel tubulin inhibitor, demonstrates the anti-cancer activity against chemotherapy-resistant cancers. Proc Amer Assoc Cancer Res, Volume 45, 2004

Chemical & Physical Properties

Density1.34
Melting Point233ºC
Molecular FormulaC22H16N4O2S
Molecular Weight400.45300
Exact Mass400.09900
PSA115.50000
LogP4.06108
Index of Refraction1.7
InChIKeyIZZYUABKZYIINT-UHFFFAOYSA-N
SMILESCc1cc(NC(=O)C(=O)c2cc(Cc3ccc(C#N)cc3)n3ccccc23)sn1
Storage condition2-8℃

Safety Information

HS Code2934999090

Customs

HS Code2934999090
Summary2934999090. other heterocyclic compounds. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:20.0%

Synonyms

UNII-6Z674O12T6
Rosabulin
I01-9450
STA-5312
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