CAS 2942-42-9|7-Nitroindazole

Introduction：Basic information about CAS 2942-42-9|7-Nitroindazole, including its chemical name, molecular formula, synonyms, physicochemical properties, and safety information, etc.

Table of Contents

1. Names
2. 7-Nitroindazole BiologicalActivity
3. Chemical & Physical Properties
4. Toxicological Information
CHEMICAL IDENTIFICATION
HEALTH HAZARD DATA
ACUTE TOXICITY DATA
MUTATION DATA
5. Safety Information
6. Customs
7. Articles63
8. Synonyms

Common Name	7-Nitroindazole
CAS Number	2942-42-9	Molecular Weight	163.133
Density	1.5±0.1 g/cm3	Boiling Point	211.2±23.0 °C at 760 mmHg
Molecular Formula	C₇H₅N₃O₂	Melting Point	185-186°C
MSDS	ChineseUSA	Flash Point	81.5±22.6 °C
Symbol	GHS06, GHS08	Signal Word	Danger

Names

Name	7-nitro-1H-indazole
Synonym	More Synonyms

7-Nitroindazole BiologicalActivity

Description	7-Nitroindazole is a selective nNOS inhibitor with antinociceptive and cardiovascular effects. 7-Nitroindazole is a useful tool to evaluate the biological roles of nitric oxide in the central nervous system[1][2].
Related Catalog	Research Areas >>Cardiovascular DiseaseSignaling Pathways >>Immunology/Inflammation >>NO SynthaseResearch Areas >>Neurological Disease
References	[1]. Moore PK, et al. 7-Nitro indazole, an inhibitor of nitric oxide synthase, exhibits anti-nociceptive activity in the mouse without increasing blood pressure. Br J Pharmacol. 1993 Feb;108(2):296-7. [2]. Moore PK, et al. Characterization of the novel nitric oxide synthase inhibitor 7-nitro indazole and related indazoles: antinociceptive and cardiovascular effects. Br J Pharmacol. 1993 Sep;110(1):219-24.

Description

7-Nitroindazole is a selective nNOS inhibitor with antinociceptive and cardiovascular effects. 7-Nitroindazole is a useful tool to evaluate the biological roles of nitric oxide in the central nervous system[1][2].

Related Catalog

Research Areas >>Cardiovascular DiseaseSignaling Pathways >>Immunology/Inflammation >>NO SynthaseResearch Areas >>Neurological Disease

References

[1]. Moore PK, et al. 7-Nitro indazole, an inhibitor of nitric oxide synthase, exhibits anti-nociceptive activity in the mouse without increasing blood pressure. Br J Pharmacol. 1993 Feb;108(2):296-7.

[2]. Moore PK, et al. Characterization of the novel nitric oxide synthase inhibitor 7-nitro indazole and related indazoles: antinociceptive and cardiovascular effects. Br J Pharmacol. 1993 Sep;110(1):219-24.

Chemical & Physical Properties

Density	1.5±0.1 g/cm3
Boiling Point	211.2±23.0 °C at 760 mmHg
Melting Point	185-186°C
Molecular Formula	C₇H₅N₃O₂
Molecular Weight	163.133
Flash Point	81.5±22.6 °C
Exact Mass	163.038177
PSA	74.50000
LogP	1.42
Vapour Pressure	0.2±0.4 mmHg at 25°C
Index of Refraction	1.741
InChIKey	PQCAUHUKTBHUSA-UHFFFAOYSA-N
SMILES	O=[N+]([O-])c1cccc2cn[nH]c12
Storage condition	−20°C
Water Solubility	slightly soluble

Toxicological Information

CHEMICAL IDENTIFICATION

RTECS NUMBER :: NK7962200

CHEMICAL NAME :: 1H-Indazole, 7-nitro-

CAS REGISTRY NUMBER :: 2942-42-9

BEILSTEIN REFERENCE NO. :: 0006809

LAST UPDATED :: 199612

DATA ITEMS CITED :: 2

MOLECULAR FORMULA :: C7-H5-N3-O2

MOLECULAR WEIGHT :: 163.15

WISWESSER LINE NOTATION :: T56 BMNJ INW

HEALTH HAZARD DATA

ACUTE TOXICITY DATA

MUTATION DATA

TYPE OF TEST :: Mutation in microorganisms

TEST SYSTEM :: Bacteria - Salmonella typhimurium

DOSE/DURATION :: 100 nmol/plate

REFERENCE :: MUREAV Mutation Research. (Elsevier Science Pub. B.V., POB 211, 1000 AE Amsterdam, Netherlands) V.1- 1964- Volume(issue)/page/year: 173,169,1986

Safety Information

Symbol	GHS06, GHS08
Signal Word	Danger
Hazard Statements	H301-H319-H351-H360
Precautionary Statements	P201-P281-P301 + P310-P305 + P351 + P338-P308 + P313
Personal Protective Equipment	Eyeshields;Faceshields;full-face particle respirator type N100 (US);Gloves;respirator cartridge type N100 (US);type P1 (EN143) respirator filter;type P3 (EN 143) respirator cartridges
Hazard Codes	T:Toxic;
Risk Phrases	R60;R40
Safety Phrases	S53-S22-S36/37/39-S45
RIDADR	UN 2811 6.1/PG 3
WGK Germany	3
RTECS	NK7962200
Hazard Class	6.1
HS Code	2933990090

Customs

HS Code	2933990090
Summary	2933990090. heterocyclic compounds with nitrogen hetero-atom(s) only. VAT:17.0%. Tax rebate rate:13.0%. . MFN tariff:6.5%. General tariff:20.0%

Articles63

Effects of prolonged neuronal nitric oxide synthase inhibition on the development and expression of L-DOPA-induced dyskinesia in 6-OHDA-lesioned rats.

Neuropharmacology 89 , 87-99, (2014)

It is well known that nitric oxide (NO) interacts with dopamine (DA) within the striatal circuitry. The anti-dyskinetic properties of NO synthase (NOS) inhibitors demonstrate the importance of NO in L...

Tapentadol and nitric oxide synthase systems.

Behav. Pharmacol. 26(3) , 282-8, (2015)

Tapentadol, a new analgesic drug with a dual mechanism of action (μ-opioid receptor agonism and norepinephrine reuptake inhibition), is indicated for the treatment of moderate to severe acute and chro...

Why Small Differences Matter: Elucidation of the Mechanisms Underlying the Transformation of 2OH- and 3OH-Carbamazepine in Contact with Sand Filter Material.

Environ. Sci. Technol. 49 , 10449-56, (2015)

Carbamazepine (CBZ) is a worldwide used antiepileptic drug, which is metabolized to a large extent in the human body to several metabolites, including 10,11-dihydroxy-10,11-dihydrocarbamazepine (DiOHC...

Synonyms

1H-Indazole,7-nitro

MFCD00022789

nitro-7 indazole

7-Nitroindazole

7-NI

2H-Indazole, 7-nitro-

7-Nitro-1H-indazole

7-Nitro-2H-indazole

EINECS 220-934-4

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