CAS 245443-52-1|PAR-4 (1-6) amide (mouse) trifluoroacetate salt

Introduction：Basic information about CAS 245443-52-1|PAR-4 (1-6) amide (mouse) trifluoroacetate salt, including its chemical name, molecular formula, synonyms, physicochemical properties, and safety information, etc.

Table of Contents

1. Names
2. BiologicalActivity
3. Chemical & Physical Properties
4. Synonyms

Common Name	PAR-4 (1-6) amide (mouse) trifluoroacetate salt
CAS Number	245443-52-1	Molecular Weight	666.76800
Density	/	Boiling Point	/
Molecular Formula	C₃₃H₄₆N₈O₇	Melting Point	/
MSDS	/	Flash Point	/

Names

Name	h-gly-tyr-pro-gly-lys-phe-nh2
Synonym	More Synonyms

BiologicalActivity

Description	Protease-Activated Receptor-4 is the agonist of proteinase-activated receptor-4 (PAR4).
Related Catalog	Signaling Pathways >>GPCR/G Protein >>Protease-Activated Receptor (PAR)Research Areas >>OthersPeptides
In Vitro	GYPGKF-NH2 significantly reduces the agonistic potency of AYPGKF-NH2 by 25-fold[1]. GYPGKF-NH2 (500 μM) does not cause contraction or relaxation of the guinea pig IAS strips[2].
References	[1]. Moschonas IC, et al. Molecular requirements involving the human platelet protease-activated receptor-4 mechanism of activation by peptide analogues of its tethered-ligand. Platelets. 2017 Mar 7:1-10. doi: 10.1080/09537104.2017.1282607. [Epub ahead of print] [2]. Huang SC, et al. Proteinase-activated receptor-1 (PAR1) and PAR2 mediate relaxation of guinea pig internal anal sphincter. Regul Pept. 2014 Feb 10;189:46-50.

Chemical & Physical Properties

Molecular Formula	C₃₃H₄₆N₈O₇
Molecular Weight	666.76800
Exact Mass	666.34900
PSA	252.07000
LogP	1.91440
InChIKey	NAIYNSCJEHHFMV-FWEHEUNISA-N
SMILES	NCCCCC(NC(=O)CNC(=O)C1CCCN1C(=O)C(Cc1ccc(O)cc1)NC(=O)CN)C(=O)NC(Cc1ccccc1)C(N)=O
Storage condition	2-8℃

Synonyms

par-4 agonist amide

gypgkfamide

gypgkf-nh2

protease-activated receptor-4 agonist amide

h2n-gypgkf-amide

GLY-TYR-PRO-GLY-LYS-PHE-NH2

Protease-Activated Receptor-4

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