CAS 469-83-0|Cafestol
Introduction：Basic information about CAS 469-83-0|Cafestol, including its chemical name, molecular formula, synonyms, physicochemical properties, and safety information, etc.
| Common Name | Cafestol | ||
|---|---|---|---|
| CAS Number | 469-83-0 | Molecular Weight | 316.435 |
| Density | 1.2±0.1 g/cm3 | Boiling Point | 468.6±45.0 °C at 760 mmHg |
| Molecular Formula | C20H28O3 | Melting Point | 160-162ºC (with decomposition) (ethyl ether pentane ) |
| MSDS | / | Flash Point | 237.2±28.7 °C |
Names
| Name | cafestol |
|---|---|
| Synonym | More Synonyms |
Cafestol BiologicalActivity
| Description | Cafestol, one of the major components of coffee, is a coffee-specific diterpene from. Cafestol is a ERK inhibitor for AP-1-targeted activity against PGE2 production and the mRNA expression of cyclooxygenase (COX)-2 in LPS-activated RAW264.7 cells. Cafestol has strong inhibitory activity on PGE2 production by suppressing the NF-kB activation pathway. Cafestol contributes to its beneficial effects through various biological activities such as chemopreventive, antitumorigenic, hepatoprotective, antioxidative and antiinflammatory effects[1]. |
|---|---|
| Related Catalog | Research Areas >>CancerResearch Areas >>Inflammation/ImmunologySignaling Pathways >>Immunology/Inflammation >>PGE synthaseSignaling Pathways >>Immunology/Inflammation >>COXSignaling Pathways >>MAPK/ERK Pathway >>ERKSignaling Pathways >>Stem Cell/Wnt >>ERK |
| Target | ERK COX-2 NF-κB |
| References | [1]. Shen T, et al. Cafestol, a coffee-specific diterpene, is a novel extracellular signal-regulated kinase inhibitor with AP-1-targeted inhibition of prostaglandin E2 production in lipopolysaccharide-activated macrophages. Biol Pharm Bull. 2010;33(1):128-32. |
Chemical & Physical Properties
| Density | 1.2±0.1 g/cm3 |
|---|---|
| Boiling Point | 468.6±45.0 °C at 760 mmHg |
| Melting Point | 160-162ºC (with decomposition) (ethyl ether pentane ) |
| Molecular Formula | C20H28O3 |
| Molecular Weight | 316.435 |
| Flash Point | 237.2±28.7 °C |
| Exact Mass | 316.203857 |
| PSA | 53.60000 |
| LogP | 4.03 |
| Vapour Pressure | 0.0±1.2 mmHg at 25°C |
| Index of Refraction | 1.604 |
| InChIKey | DNJVYWXIDISQRD-HWUKTEKMSA-N |
| SMILES | CC12CCc3occc3C1CCC13CC(CCC12)C(O)(CO)C3 |
Synonyms
| (1S,4S,12S,13R,16R,17R)-17-(Hydroxymethyl)-12-methyl-8-oxapentacyclo[14.2.1.0.0.0]nonadeca-5(9),6-dien-17-ol |
| unii-ac465t6q6w |
