Introduction：Basic information about CAS 94805-82-0|glycycoumarin, including its chemical name, molecular formula, synonyms, physicochemical properties, and safety information, etc.
| Common Name | glycycoumarin |
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| CAS Number | 94805-82-0 | Molecular Weight | 368.380 |
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| Density | 1.3±0.1 g/cm3 | Boiling Point | 646.9±55.0 °C at 760 mmHg |
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| Molecular Formula | C21H20O6 | Melting Point | 243.5-244.5℃ |
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| MSDS | / | Flash Point | 232.0±25.0 °C |
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Names
| Name | glycycoumarin |
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| Synonym | More Synonyms |
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glycycoumarin BiologicalActivity
| Description | Glycycoumarin is a major bioactive coumarin of licorice. Glycycoumarin inhibits hepatocyte lipoapoptosis through activation of autophagy and inhibition of ER stress-mediated JNK and GSK-3-mediated mitochondrial pathway. Glycycoumarin exerts anti-liver cancer activity by directly targeting T-LAK cell-originated protein kinase [1] [2]. |
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| Related Catalog | Research Areas >>CancerSignaling Pathways >>Autophagy >>Autophagy |
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| References | [1]. Zhang E, et al. Glycycoumarin inhibits hepatocyte lipoapoptosis through activation of autophagy and inhibition of ER stress/GSK-3-mediated mitochondrial pathway. Sci Rep. 2016 Nov 30;6:38138. [2]. Song X, et al. Glycycoumarin exerts anti-liver cancer activity by directly targeting T-LAK cell-originated protein kinase. Oncotarget. 2016 Oct 4;7(40):65732-65743. |
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Chemical & Physical Properties
| Density | 1.3±0.1 g/cm3 |
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| Boiling Point | 646.9±55.0 °C at 760 mmHg |
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| Melting Point | 243.5-244.5℃ |
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| Molecular Formula | C21H20O6 |
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| Molecular Weight | 368.380 |
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| Flash Point | 232.0±25.0 °C |
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| Exact Mass | 368.125977 |
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| PSA | 100.13000 |
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| LogP | 5.99 |
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| Vapour Pressure | 0.0±2.0 mmHg at 25°C |
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| Index of Refraction | 1.649 |
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| InChIKey | NZYSZZDSYIBYLC-UHFFFAOYSA-N |
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| SMILES | COc1c(CC=C(C)C)c(O)cc2oc(=O)c(-c3ccc(O)cc3O)cc12 |
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Safety Information
Synonyms
| 3-(2,4-Dihydroxy-phenyl)-7-hydroxy-5-methoxy-6-(3-methyl-but-2-enyl)-1-benzopyran-2-one |
| 3-(2,4-Dihydroxyphenyl)-7-hydroxy-5-methoxy-6-(3-methyl-2-buten-1-yl)-2H-chromen-2-one |
| glycycoumarin |
| 2H-1-Benzopyran-2-one, 3-(2,4-dihydroxyphenyl)-7-hydroxy-5-methoxy-6-(3-methyl-2-buten-1-yl)- |
| 3-(2,4-dihydroxyphenyl)-7-hydroxy-5-methoxy-6-(3-methylbut-2-enyl)chromen-2-one |
