CAS 484-14-0|Osthenol
Introduction：Basic information about CAS 484-14-0|Osthenol, including its chemical name, molecular formula, synonyms, physicochemical properties, and safety information, etc.
| Common Name | Osthenol | ||
|---|---|---|---|
| CAS Number | 484-14-0 | Molecular Weight | 230.25900 |
| Density | 1.203g/cm3 | Boiling Point | 422.8ºC at 760 mmHg |
| Molecular Formula | C14H14O3 | Melting Point | / |
| MSDS | / | Flash Point | 184.1ºC |
Names
| Name | 7-hydroxy-8-(3-methylbut-2-enyl)chromen-2-one |
|---|---|
| Synonym | More Synonyms |
Osthenol BiologicalActivity
| Description | Osthenol (Ostenol), a prenylated coumarin isolated from the dried roots of Angelica pubescens, is selective, reversible, and competitive human monoamine oxidase-A (hMAO-A) inhibitor (Ki=0.26 µM). Osthenol potently inhibits recombinant hMAO-A with an IC50 of 0.74 µM and shows a high selectivity index for hMAO-A versus hMAO-B[1]. |
|---|---|
| Related Catalog | Signaling Pathways >>Neuronal Signaling >>Monoamine OxidaseResearch Areas >>Neurological Disease |
| Target | hMAO-A:0.26 μM (Ki) hMAO-A:0.74 μM (IC50) |
| References | [1]. Baek SC, et al. Osthenol, a prenylated coumarin, as a monoamine oxidase A inhibitor with high selectivity. Bioorg Med Chem Lett. 2019;29(6):839-843. [2]. Liao ZC, et al. Zhongguo Zhong Yao Za Zhi. 2017;42(15):2999-3003. |
Chemical & Physical Properties
| Density | 1.203g/cm3 |
|---|---|
| Boiling Point | 422.8ºC at 760 mmHg |
| Molecular Formula | C14H14O3 |
| Molecular Weight | 230.25900 |
| Flash Point | 184.1ºC |
| Exact Mass | 230.09400 |
| PSA | 50.44000 |
| LogP | 3.00730 |
| Vapour Pressure | 9.53E-08mmHg at 25°C |
| Index of Refraction | 1.595 |
| InChIKey | RAKJVIPCCGXHHS-UHFFFAOYSA-N |
| SMILES | CC(C)=CCc1c(O)ccc2ccc(=O)oc12 |
| Storage condition | 2-8℃ |
Synonyms
| 7-Hydroxy-8-Prenyl coumarin |
| Osthenol |
