Introduction：Basic information about CAS 60008-03-9|2',2'-Dimethyl-2H,2'H-3,8'-bichromene-5',7-diol, including its chemical name, molecular formula, synonyms, physicochemical properties, and safety information, etc.
| Common Name | 2',2'-Dimethyl-2H,2'H-3,8'-bichromene-5',7-diol |
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| CAS Number | 60008-03-9 | Molecular Weight | 322.354 |
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| Density | 1.3±0.1 g/cm3 | Boiling Point | 536.3±50.0 °C at 760 mmHg |
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| Molecular Formula | C20H18O4 | Melting Point | / |
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| MSDS | / | Flash Point | 278.2±30.1 °C |
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Names
| Name | 8-(7-hydroxy-2H-chromen-3-yl)-2,2-dimethylchromen-5-ol |
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| Synonym | More Synonyms |
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BiologicalActivity
| Description | Glabrene, an isoflavene derived from licorice root, shows estrogen-like activity. Glabrene is a tyrosinase inhibitor with an IC50 of 3.5 μM[1][2]. |
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| Related Catalog | Research Areas >>OthersSignaling Pathways >>Metabolic Enzyme/Protease >>Tyrosinase |
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| Target | IC50: 3.5 μM (Tyrosinase)[2] |
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| References | [1]. Somjen D, et al. Estrogenic activity of glabridin and glabrene from licorice roots on human osteoblasts and prepubertal rat skeletal tissues. J Steroid Biochem Mol Biol. 2004 Aug;91(4-5):241-6. [2]. Nerya O, et al. Glabrene and isoliquiritigenin as tyrosinase inhibitors from licorice roots. J Agric Food Chem. 2003 Feb 26;51(5):1201-7 |
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Chemical & Physical Properties
| Density | 1.3±0.1 g/cm3 |
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| Boiling Point | 536.3±50.0 °C at 760 mmHg |
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| Molecular Formula | C20H18O4 |
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| Molecular Weight | 322.354 |
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| Flash Point | 278.2±30.1 °C |
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| Exact Mass | 322.120514 |
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| PSA | 58.92000 |
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| LogP | 6.72 |
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| Vapour Pressure | 0.0±1.5 mmHg at 25°C |
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| Index of Refraction | 1.647 |
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| InChIKey | NGGYSPUAKQMTNP-UHFFFAOYSA-N |
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| SMILES | CC1(C)C=Cc2c(O)ccc(C3=Cc4ccc(O)cc4OC3)c2O1 |
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Safety Information
| Hazard Codes | Xi |
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| HS Code | 2905399090 |
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Customs
| HS Code | 2905399090 |
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| Summary | 2905399090 other diols。supervision conditions:AB(certificate of inspection for goods inward,certificate of inspection for goods outward)。VAT:17.0%。tax rebate rate:9.0%。MFN tariff:5.5%。general tariff:30.0% |
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Synonyms
| 2',2'-Dimethyl-2H,2'H-3,8'-bichromene-5',7-diol |
| Glabrene |
| [3,8'-Bi-2H-1-benzopyran]-5',7-diol, 2',2'-dimethyl- |
