Introduction：Basic information about CAS 56121-42-7|Aurantiamide acetate, including its chemical name, molecular formula, synonyms, physicochemical properties, and safety information, etc.
| Common Name | Aurantiamide acetate |
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| CAS Number | 56121-42-7 | Molecular Weight | 444.522 |
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| Density | 1.2±0.1 g/cm3 | Boiling Point | 716.1±60.0 °C at 760 mmHg |
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| Molecular Formula | C27H28N2O4 | Melting Point | / |
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| MSDS | / | Flash Point | 386.9±32.9 °C |
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Names
| Name | Asperglaucide |
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| Synonym | More Synonyms |
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Aurantiamide acetate BiologicalActivity
| Description | Aurantiamide acetate (TMC-58A) is a selective and orally active cathepsin inhibitor isolated from Portulaca oleracea L. Aurantiamide acetate has anti-inflammatory activities and can be used for the study of inflammatory diseases[1][2]. |
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| Related Catalog | Research Areas >>Inflammation/ImmunologySignaling Pathways >>Metabolic Enzyme/Protease >>Cathepsin |
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| In Vitro | Aurantiamide acetate inhibits cathepsin L (3.4.22.15) and cathepsin B (3.4.22.1) with IC50 of 12 μM and 49 μM, respectiveiy[1]. |
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| References | [1]. K Isshiki, et al. Aurantiamide Acetate, a Selective Cathepsin Inhibitor, Produced by Aspergillus Penicilloides. Biosci Biotechnol Biochem. 2001 May;65(5):1195-7. [2]. Chi-Su Yoon, et al. Anti-neuroinflammatory Effect of Aurantiamide Acetate From the Marine Fungus Aspergillus Sp. SF-5921: Inhibition of NF-κB and MAPK Pathways in Lipopolysaccharide-Induced Mouse BV2 Microglial Cells.Int Immunopharmacol. 2014 Dec;23(2):568-74. |
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Chemical & Physical Properties
| Density | 1.2±0.1 g/cm3 |
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| Boiling Point | 716.1±60.0 °C at 760 mmHg |
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| Molecular Formula | C27H28N2O4 |
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| Molecular Weight | 444.522 |
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| Flash Point | 386.9±32.9 °C |
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| Exact Mass | 444.204895 |
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| PSA | 84.50000 |
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| LogP | 4.58 |
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| Vapour Pressure | 0.0±2.3 mmHg at 25°C |
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| Index of Refraction | 1.587 |
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| InChIKey | VZPAURMDJZOGHU-SKCDSABHSA-N |
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| SMILES | CC(=O)OCC(Cc1ccccc1)NC(=O)C(Cc1ccccc1)NC(=O)c1ccccc1 |
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Safety Information
Synonyms
| (2S)-2-[(N-Benzoyl-L-phenylalanyl)amino]-3-phenylpropyl acetate |
| Benzenepropanamide, N-[(1S)-2-(acetyloxy)-1-(phenylmethyl)ethyl]-α-(benzoylamino)-, (αS)- |
| Asperglaucide |
